Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Jan Albert Kuivenhoven"'
Autor:
Cristy R.C. Verzijl, Federico Oldoni, Natalia Loaiza, Justina C. Wolters, Antoine Rimbert, E. Tian, Weiming Yang, Dicky Struik, Marieke Smit, Niels J. Kloosterhuis, Amy J. Fernandez, Nadine L. Samara, Kelly G. Ten Hagen, Kruti Dalal, Aliona Chernish, Peggy McCluggage, Lawrence A. Tabak, Johan W. Jonker, Jan Albert Kuivenhoven
Publikováno v:
Molecular Metabolism, Vol 60, Iss , Pp 101472- (2022)
Objective: GALNT2, encoding polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2), was initially discovered as a regulator of high-density lipoprotein metabolism. GalNAc-T2 is known to exert these effects through post-translational modification
Externí odkaz:
https://doaj.org/article/ed1b5a2f73a641f4a58ccdb15e609510
Autor:
Kaare R. Norum, Alan T. Remaley, Helena E. Miettinen, Erik H. Strøm, Bruno E.P. Balbo, Carlos A.T.L. Sampaio, Ingrid Wiig, Jan Albert Kuivenhoven, Laura Calabresi, John J. Tesmer, Mingyue Zhou, Dominic S. Ng, Bjørn Skeie, Sotirios K. Karathanasis, Kelly A. Manthei, Kjetil Retterstøl
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 8, Pp 1142-1149 (2020)
LCAT converts free cholesterol to cholesteryl esters in the process of reverse cholesterol transport. Familial LCAT deficiency (FLD) is a genetic disease that was first described by Kaare R. Norum and Egil Gjone in 1967. This report is a summary from
Externí odkaz:
https://doaj.org/article/1eb59149604d406ab618b04f2a2cf3f0
Autor:
Antoine Rimbert, Hinda Daggag, Peter Lansberg, Adam Buckley, Martijn Viel, Roan Kanninga, Lennart Johansson, Robin P. F. Dullaart, Richard Sinke, Alia Al Tikriti, Jan Albert Kuivenhoven, Maha Taysir Barakat
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Background: Programs to screen for Familial hypercholesterolemia (FH) are conducted worldwide. In Western societies, these programs have been shown to be cost-effective with hit/detection rates of 1 in 217–250. Thus far, there is no published data
Externí odkaz:
https://doaj.org/article/eaf9b976ba754ec484d049b2491a93a8
Autor:
Xiang Zhang, Antoine Rimbert, Willem Balder, Aeilko Having Zwinderman, Jan Albert Kuivenhoven, Geesje Margaretha Dallinga-Thie, Albert Kornelis Groen
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 11, Pp 2174-2180 (2018)
Hypercholesterolemia is characterized by high plasma LDL cholesterol and often caused by genetic mutations in LDL receptor (LDLR), APOB, or proprotein convertase subtilisin/kexin type 9 (PCSK9). However, a substantial proportion of hypercholesterolem
Externí odkaz:
https://doaj.org/article/32a25caf16684eb1a2b8447b23252be4
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 1, p 4 (2021)
New drugs targeting bile acid metabolism are currently being evaluated in clinical studies for their potential to treat cholestatic liver diseases, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Changes in bile ac
Externí odkaz:
https://doaj.org/article/943682c527274f1a85f3b448b5fb0075
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
Autor:
Paulina Bartuzi, Daniel D. Billadeau, Robert Favier, Shunxing Rong, Daphne Dekker, Alina Fedoseienko, Hille Fieten, Melinde Wijers, Johannes H. Levels, Nicolette Huijkman, Niels Kloosterhuis, Henk van der Molen, Gemma Brufau, Albert K. Groen, Alison M. Elliott, Jan Albert Kuivenhoven, Barbara Plecko, Gernot Grangl, Julie McGaughran, Jay D. Horton, Ezra Burstein, Marten H. Hofker, Bart van de Sluis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Low density lipoprotein receptor (LDLR) is crucial for cholesterol homeostasis. Here, the authors show that components of the CCC-protein complex, CCDC22 and COMMD1, facilitate the endosomal sorting of LDLR and that mutations in these genes cause hyp
Externí odkaz:
https://doaj.org/article/8e60ef48969c43c189785a273159992f
Publikováno v:
Journal of Clinical Medicine, Vol 8, Iss 7, p 1085 (2019)
The recent introduction of inhibitors of proprotein convertase subtilisin/kexin 9 to lower low-density lipoprotein (LDL) cholesterol on top of statins or as monotherapy is rapidly changing the landscape of treatment of atherosclerotic cardiovascular
Externí odkaz:
https://doaj.org/article/f2bdae9ecf2e4001b04d301d83d67ea7
Autor:
Adriaan G. Holleboom, Lily Jakulj, Remco Franssen, Julie Decaris, Menno Vergeer, Joris Koetsveld, Jayraz Luchoomun, Alexander Glass, Marc K. Hellerstein, John J.P. Kastelein, G. Kees Hovingh, Jan Albert Kuivenhoven, Albert K. Groen, Scott M. Turner, Erik S.G. Stroes
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 7, Pp 1964-1971 (2013)
Atheroprotection by high density lipoprotein (HDL) is considered to be mediated through reverse cholesterol transport (RCT) from peripheral tissues. We investigated in vivo cholesterol fluxes through the RCT pathway in patients with low plasma high d
Externí odkaz:
https://doaj.org/article/eb57f8d7a91447d3adb89517819b0787
Autor:
Menno Hoekstra, Suzanne J.A. Korporaal, Ronald J. van der Sluis, Veronica Hirsch-Reinshagen, Andrea E. Bochem, Cheryl L. Wellington, Theo J.C. Van Berkel, Jan Albert Kuivenhoven, Miranda Van Eck
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 2, Pp 358-364 (2013)
In vitro studies have suggested that HDL and apoB-containing lipoproteins can provide cholesterol for synthesis of glucocorticoids. Here we assessed adrenal glucocorticoid function in LCAT knockout (KO) mice to determine the specific contribution of
Externí odkaz:
https://doaj.org/article/6fcb5206da854ef79fc2971279a3e432
Publikováno v:
Frontiers in Physiology, Vol 6 (2015)
When considering the variation in the genome, transcriptome, proteome and metabolome, and their interaction with the environment, every individual can be rightfully considered as a unique biological entity. Individualized medicine promises to take th
Externí odkaz:
https://doaj.org/article/d39c411097a54e02bf9f91309c7374d5