Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Jan A. Stevens"'
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114110- (2024)
Summary: Transmembrane transporter proteins are essential for maintaining cellular homeostasis and, as such, are key drug targets. Many transmembrane transporter proteins are known to undergo large structural rearrangements during their functional cy
Externí odkaz:
https://doaj.org/article/981068598b8847a4a08dbaa2b43d9608
Autor:
Benjamin R. Gilbert, Zane R. Thornburg, Troy A. Brier, Jan A. Stevens, Fabian Grünewald, John E. Stone, Siewert J. Marrink, Zaida Luthey-Schulten
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Computational models of cells cannot be considered complete unless they include the most fundamental process of life, the replication and inheritance of genetic material. By creating a computational framework to model systems of replicating bacterial
Externí odkaz:
https://doaj.org/article/42b2539a78d14ebabeca3d47e234ce28
Autor:
Jan A. Stevens, Fabian Grünewald, P. A. Marco van Tilburg, Melanie König, Benjamin R. Gilbert, Troy A. Brier, Zane R. Thornburg, Zaida Luthey-Schulten, Siewert J. Marrink
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
The ultimate microscope, directed at a cell, would reveal the dynamics of all the cell’s components with atomic resolution. In contrast to their real-world counterparts, computational microscopes are currently on the brink of meeting this challenge
Externí odkaz:
https://doaj.org/article/ec6346a36976419a93f6e9f4abc90255
Autor:
Payel Kundu, Sarah Holden, Ines L. Paraiso, Reetesh Sudhakar, Chloe McQuesten, Jaewoo Choi, Cristobal L. Miranda, Claudia S. Maier, Gerd Bobe, Jan F. Stevens, Jacob Raber
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Consumption of a high fat diet (HFD) is linked to metabolic syndrome and cognitive impairments. This is exacerbated in age-related cognitive decline (ACD) and in individuals with a genetic risk for Alzheimer’s disease (AD). Apolipoprotein E (apoE)
Externí odkaz:
https://doaj.org/article/6da310e68f4e4e4aad956e7b1ab81a6f
Autor:
Ryan Bradley, Blake O. Langley, Jennifer J. Ryan, John Phipps, Douglas A. Hanes, Emily Stack, Janet K. Jansson, Thomas O. Metz, Jan Frederik Stevens
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background Natural products may provide a source for the discovery and development of adjunctive pharmacological interventions to modulate the inflammatory pathways contributing to chronic disease. Xanthohumol, a flavonoid from the hops plan
Externí odkaz:
https://doaj.org/article/7f64c9db81dd4990b1a7fd281c5c0f2e
Autor:
Kirsten M. Wright, Janis McFerrin, Armando Alcázar Magaña, Joanne Roberts, Maya Caruso, Doris Kretzschmar, Jan F. Stevens, Claudia S. Maier, Joseph F. Quinn, Amala Soumyanath
Publikováno v:
Frontiers in Nutrition, Vol 8 (2022)
Botanical products are frequently sold as dietary supplements and their use by the public is increasing in popularity. However, scientific evaluation of their medicinal benefits presents unique challenges due to their chemical complexity, inherent va
Externí odkaz:
https://doaj.org/article/0047909dd93442a8aa619fec9842b565
Autor:
Alex B. Speers, Manuel García-Jaramillo, Alicia Feryn, Donald G. Matthews, Talia Lichtenberg, Maya Caruso, Kirsten M. Wright, Joseph F. Quinn, Jan F. Stevens, Claudia S. Maier, Amala Soumyanath, Nora E. Gray
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Centella asiatica is an herb used in Ayurvedic and traditional Chinese medicine for its beneficial effects on brain health and cognition. Our group has previously shown that a water extract of Centella asiatica (CAW) elicits cognitive-enhancing effec
Externí odkaz:
https://doaj.org/article/440d265ece404eec870a0c4bfc119167
Autor:
Yang Zhang, Gerd Bobe, Cristobal L Miranda, Malcolm B Lowry, Victor L Hsu, Christiane V Lohr, Carmen P Wong, Donald B Jump, Matthew M Robinson, Thomas J Sharpton, Claudia S Maier, Jan F Stevens, Adrian F Gombart
Publikováno v:
eLife, Vol 10 (2021)
We previously reported xanthohumol (XN), and its synthetic derivative tetrahydro-XN (TXN), attenuates high-fat diet (HFD)-induced obesity and metabolic syndrome in C57Bl/6J mice. The objective of the current study was to determine the effect of XN an
Externí odkaz:
https://doaj.org/article/2429acd383fb4e10be829a3c44468c2f
Autor:
Tony J. Zheng, Tia C. L. Kohs, Paul A. Mueller, Jiaqing Pang, Stéphanie E. Reitsma, Iván Parra-Izquierdo, Alexander R. Melrose, Liping Yang, Jaewoo Choi, Keith D. Zientek, Denis O. Sviridov, Mark K. Larson, Craig D. Williams, Nathalie Pamir, Joseph J. Shatzel, Ashok P. Reddy, Paul Kievit, Alan T. Remaley, Jan F. Stevens, Monica T. Hinds, Owen J. T. McCarty, Joseph E. Aslan
Publikováno v:
Blood Advances. 7:1366-1378
Low-density lipoprotein (LDL) contributes to atherogenesis and cardiovascular disease through interactions with peripheral blood cells, especially platelets. However, mechanisms by which LDL affects platelet activation and atherothrombosis, and how t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb9061d7c836954e38769f23cd4424c
https://doi.org/10.1182/bloodadvances.2022007169
https://doi.org/10.1182/bloodadvances.2022007169
Publikováno v:
Burns. 49:120-128
Treatment for pediatric burns includes fluid resuscitation with formulas estimating fluid requirements based on weight and/or body surface area (BSA) with percent total body surface area burn (%TBSA burn). This study evaluates the risk of complicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956e02bdcff732b5ea5568bb4ceb0ff8
https://doi.org/10.1016/j.burns.2022.03.007
https://doi.org/10.1016/j.burns.2022.03.007