Zobrazeno 1 - 10
of 359
pro vyhledávání: '"Jan A. Mol"'
Autor:
Elpetra P. M. Timmermans, Joëlle Blankevoort, Guy C. M. Grinwis, Sietske J. Mesu, Ronette Gehring, Patric J. D. Delhanty, Peter E. M. Maas, Ger J. Strous, Jan A. Mol
Publikováno v:
Pharmaceuticals, Vol 17, Iss 10, p 1381 (2024)
Background: The activation of the growth hormone receptor (GHR) is a major determinant of body growth. Defective GHR signaling, as seen in human Laron dwarfism, resulted in low plasma IGF-1 concentrations and limited growth, but also marked absence i
Externí odkaz:
https://doaj.org/article/5b4489a9c71247ea899d31c04259ad42
Autor:
Tugce Apaydin, Svetlana Zonis, Cuiqi Zhou, Christian Wong Valencia, Robert Barrett, Ger J. Strous, Jan A. Mol, Vera Chesnokova, Shlomo Melmed
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108117- (2023)
Summary: DNA damage repair (DDR) is mediated by phosphorylating effectors ATM kinase, CHK2, p53, and γH2AX. We showed earlier that GH suppresses DDR by suppressing pATM, resulting in DNA damage accumulation. Here, we show GH acting through GH recept
Externí odkaz:
https://doaj.org/article/b5f82b10752d46ddb107f6fd1578f0a5
Autor:
Nikolaos Farmakidis, Jacob L. Swett, Nathan Youngblood, Xuan Li, Charalambos Evangeli, Samarth Aggarwal, Jan A. Mol, Harish Bhaskaran
Publikováno v:
Microsystems & Nanoengineering, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract Nanofabrication has experienced extraordinary progress in the area of lithography-led processes over the last decades, although versatile and adaptable techniques addressing a wide spectrum of materials are still nascent. Scanning probe lith
Externí odkaz:
https://doaj.org/article/343db7ad10b6455b815e436784763aac
Autor:
Lieke M. van der Velden, Peter Maas, Miranda van Amersfoort, Elpetra P M. Timmermans-Sprang, Anneloes Mensinga, Elisabeth van der Vaart, Fabrice Malergue, Henk Viëtor, Patrick W B. Derksen, Judith Klumperman, Andreas van Agthoven, David A. Egan, Jan A. Mol, Ger J. Strous
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Growth hormone (GH) and insulin‐like growth factor‐1 (IGF1) play an important role in mammalian development, cell proliferation and lifespan. Especially in cases of tumor growth there is an urgent need to control the GH/IGF1 axis. In this study w
Externí odkaz:
https://doaj.org/article/6f999f5cbc62488d94457d2a397848c2
Autor:
James O. Thomas, Bart Limburg, Jakub K. Sowa, Kyle Willick, Jonathan Baugh, G. Andrew D. Briggs, Erik M. Gauger, Harry L. Anderson, Jan A. Mol
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
The mechanism of nonadiabatic electron transfer in molecular systems is an important research topic for understanding various chemical reactions. Thomas et al. quantify resonant charge transport through single-molecule junctions as a model system for
Externí odkaz:
https://doaj.org/article/2b7f3394181b4c38b441af7fca5482a6
Autor:
Ger J. Strous, Ana Da Silva Almeida, Joyce Putters, Julia Schantl, Magdalena Sedek, Johan A. Slotman, Tobias Nespital, Gerco C. Hassink, Jan A. Mol
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
The GHR signaling pathway plays important roles in growth, metabolism, cell cycle control, immunity, homeostatic processes, and chemoresistance via both the JAK/STAT and the SRC pathways. Dysregulation of GHR signaling is associated with various dise
Externí odkaz:
https://doaj.org/article/f54837c6dbd34bc3a5f7c91870b0008a
Autor:
Gayathri Thevi Selvarajah, Floor A. S. Bonestroo, Elpetra P. M. Timmermans Sprang, Jolle Kirpensteijn, Jan A. Mol
Publikováno v:
BMC Veterinary Research, Vol 13, Iss 1, Pp 1-8 (2017)
Abstract Background Quantitative PCR (qPCR) is a common method for quantifying mRNA expression. Given the heterogeneity present in tumor tissues, it is crucial to normalize target mRNA expression data using appropriate reference genes that are stably
Externí odkaz:
https://doaj.org/article/b3d24503881643bb86c2cca190fa8b3d
Autor:
Muhammad M. Mirza, Felix J. Schupp, Jan A. Mol, Donald A. MacLaren, G. Andrew D. Briggs, Douglas J. Paul
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Junction-less nanowire transistors are being investigated to solve short channel effects in future CMOS technology. Here we demonstrate 8 nm diameter silicon nanowire junction-less transistors with metallic doping densities which demonstrate
Externí odkaz:
https://doaj.org/article/43a822918176408ba22986aa9ee34ad2
Autor:
Eugenia Pyurbeeva, Jan A. Mol
Publikováno v:
Entropy, Vol 23, Iss 6, p 640 (2021)
The entropy of a system gives a powerful insight into its microscopic degrees of freedom; however, standard experimental ways of measuring entropy through heat capacity are hard to apply to nanoscale systems, as they require the measurement of increa
Externí odkaz:
https://doaj.org/article/5fd2b67f287d40c4848f2dac375c7da0
Autor:
Achim Harzheim, Jakub K. Sowa, Jacob L. Swett, G. Andrew D. Briggs, Jan A. Mol, Pascal Gehring
Publikováno v:
Physical Review Research, Vol 2, Iss 1, p 013140 (2020)
The power factor of a thermoelectric device is a measure of the heat-to-energy conversion efficiency in nanoscopic devices. Yet, even as interest in low-dimensional thermoelectric materials has increased, experimental research on what influences the
Externí odkaz:
https://doaj.org/article/95bbc0493bfa4751a0fa27c76dcecf55