Host Transcription Profiles upon Primary Respiratory Syncytial Virus Infection

Autor: Anne-Marie Buisman, Riny Janssen, Hennie M. Hodemaekers, Jeroen L. A. Pennings, Jan A. M. A. Dormans, Lia G. H. de Rond, Kemal Öztürk, Tjeerd G. Kimman, Marijke van Oosten, Barbara Hoebee

Publikováno v: Journal of Virology. 81:5958-5967

Respiratory syncytial virus (RSV) is a common cause of severe lower respiratory tract infection in children. Severe RSV disease is related to an inappropriate immune response to RSV resulting in enhanced lung pathology which is influenced by host gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4cf9db4353535a17050d50d817bf1c4
https://doi.org/10.1128/jvi.02220-06

Respiratory syncytial virus enhances respiratory allergy in mice despite the inhibitory effect of virus-induced interferon-y

Autor: Marion Barends, Lia de Rond, Joan Kwakkel, Tjeerd G. Kimman, Herman J. Neijens, Marijke van Oosten, Anita Boelen, Jan A. M. A. Dormans

Publikováno v: Journal of Medical Virology, 69, 156-162. Wiley-Liss Inc.
Journal of medical virology, 69(1), 156-162. Wiley-Liss Inc.

In mice, respiratory syncytial virus (RSV) infection during allergic provocation aggravates the allergic Th2 immune response, characterised by production of interleukin (IL)-4, IL-5, and IL-13, and eosinophilic inflammation. This enhancement of the T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69ba3fdde2fff48c1e5aa6c39ccf325
https://doi.org/10.1002/jmv.10252

Both immunisation with a formalin-inactivated respiratory syncytial virus (RSV) vaccine and a mock antigen vaccine induce severe lung pathology and a Th2 cytokine profile in RSV-challenged mice

Autor: Theo M. Bestebroer, Jan A. M. A. Dormans, Anita Boelen, Arno C. Andeweg, Wil Lokhorst, Joan Kwakkel, Tjeerd G. Kimman

Publikováno v: Vaccine, 19(7-8), 982-991. Elsevier BV
Vaccine, 19, 982-991. Elsevier

Respiratory syncytial virus (RSV) is the most important cause of bronchiolitis and pneumonia in infants and young children. Immunopathology may play a role in RSV-induced disease and a severe RSV infection may also be associated with an increased ris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51cf187f82625d61155eef7e4bbfbccb
https://doi.org/10.1016/s0264-410x(00)00213-9

Infection with the roundworm Toxocara canis leads to exacerbation of experimental allergic airway inflammation

Autor: Jan A. M. A. Dormans, Eric R. Gremmer, Sietze Brandes, Elena Pinelli, H. van Loveren

Publikováno v: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 38(4)

Summary Background Epidemiological studies performed in developing as well as in western countries suggest that infection with Toxocara canis contributes to the development of atopic diseases. Objectives To investigate the association between infecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97243a84df54e4bc65ff50838834d670
https://pubmed.ncbi.nlm.nih.gov/18241245

Subchronic inhalation of mixtures of cigarette smoke constituents in Xpa-/-p53+/- knock-out mice: a comparison of intermittent with semi-continuous exposure to acetaldehyde, formaldehyde, and acrolein

Autor: Jan A. M. A. Dormans, A. van de Kuil, H. van Steeg, Paul H. B. Fokkens, Flemming R. Cassee, W. Vleeming, B. Rambali, J.G.C. van Amsterdam, C.Y. de Burbure, Antoon Opperhuizen

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 46(2)

We investigated whether inhaling peak concentrations of aldehydes several times daily is more damaging than semi-continuously inhaling low-dose aldehydes. We exposed Xpa-/-p53+/- knock-out mice either intermittently or semi-continuously to mixed acet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91f893f6a63e1b1de1c6c5da09fed44
https://pubmed.ncbi.nlm.nih.gov/17936466