Výsledky vyhledávání - "Jan A. Kullmann"

Profilin1-Dependent F-Actin Assembly Controls Division of Apical Radial Glia and Neocortex Development

Autor: Silvia Cappello, Jan A Kullmann, Christina Kyrousi, Marco B. Rust, Nora Bartels, Fabrizia Pipicelli, Sophie Meyer, Felix Schneider

Publikováno v: Cerebral cortex (New York, N.Y. : 1991). 30(6)

Neocortex development depends on neural stem cell proliferation, cell differentiation, neurogenesis, and neuronal migration. Cytoskeletal regulation is critical for all these processes, but the underlying mechanisms are only poorly understood. We pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa06fbc7022d944c391296282720e108
https://pubmed.ncbi.nlm.nih.gov/31867667

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Oxygen Tension and the VHL-Hif1α Pathway Determine Onset of Neuronal Polarization and Cerebellar Germinal Zone Exit

Autor: Niraj Trivedi, Abbas Shirinifard, Jan A. Kullmann, Christophe Laumonnerie, Vien Nguyen, Shalini S. Banerjee, David H. Rowitch, Danielle Howell, David J. Solecki, Daniel R. Stabley

Publikováno v: Neuron. 106:607-623.e5

Postnatal brain circuit assembly is driven by temporally regulated intrinsic and cell-extrinsic cues that organize neurogenesis, migration, and axo-dendritic specification in post-mitotic neurons. While cell polarity is an intrinsic organizer of morp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb604fecf65ff07178c06a289f862b86
https://doi.org/10.1016/j.neuron.2020.02.025

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Oxygen-Tension and the VHL-Hif1α Pathway Comprise a Developmental Switch Controlling the Onset of Neuronal Polarization and Germinal Zone Exit

Autor: Christophe Laumonnerie, Vien Nguyen, Danielle Howell, Shalini S. Banerjee, Abbas Shirinifard, Niraj Trivedi, David J. Solecki, David H. Rowitch, Daniel R. Stabley, Jan A. Kullmann

Publikováno v: SSRN Electronic Journal.

Postnatal brain circuit assembly is driven by temporally regulated intrinsic and cell-extrinsic cues that organize neurogenesis, migration, and axo-dendritic specification in post-mitotic neurons. Despite studies implicating cell polarity as an intri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9870126f6775a263b56ea72e91ac3720
https://doi.org/10.2139/ssrn.3213914

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Role of the actin-binding protein profilin1 in radial migration and glial cell adhesion of granule neurons in the cerebellum

Autor: Walter Witke, Jan A Kullmann, Marco B. Rust

Publikováno v: Cell Adhesion & Migration. 6:13-17

Profilins are small G-actin-binding proteins essential for cytoskeletal dynamics. Of the four mammalian profilin isoforms, profilin1 shows a broad expression pattern, profilin2 is abundant in the brain, and profilin3 and profilin4 are restricted to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e6d0fddfcd1cc917fd371c61f02310
https://doi.org/10.4161/cam.19845

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Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons

Autor: Christine B. Gurniak, Eckhard Friauf, Alexander Neumeyer, Walter Witke, Marco B. Rust, Jan A Kullmann

Publikováno v: EMBO reports. 13:75-82

Cerebellar granule neurons (CGNs) exploit Bergmann glia (BG) fibres for radial migration, and cell-cell contacts have a pivotal role in this process. Nevertheless, little is known about the mechanisms that control CGN-BG interaction. Here we demonstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9adb05b70430caab1530c4cf2b19a1
https://doi.org/10.1038/embor.2011.211

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Profilin1 activity in cerebellar granule neurons is required for radial migration in vivo

Autor: Jan A Kullmann, Eckhard Friauf, Ines Wickertsheim, Lara Minnerup, Mercedes Costell, Marco B. Rust

Publikováno v: Cell adhesionmigration. 9(3)

Neuron migration defects are an important aspect of human neuropathies. The underlying molecular mechanisms of such migration defects are largely unknown. Actin dynamics has been recognized as an important determinant of neuronal migration, and we re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d97b2e1742e65cee4010c6b3c3eb664
https://pubmed.ncbi.nlm.nih.gov/25495756

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Purkinje cell loss and motor coordination defects in profilin1 mutant mice

Autor: I. Wickertsheim, Jan A Kullmann, Joachim W. Deitmer, Ralph T. Böttcher, Walter Witke, Eckhard Friauf, Mercedes Costell, Alexander Neumeyer, Marco B. Rust

Publikováno v: Neuroscience. 223

Profilin1 is an actin monomer-binding protein, essential for cytoskeletal dynamics. Based on its broad expression in the brain and the localization at excitatory synapses (hippocampal CA3-CA1 synapse, cerebellar parallel fiber (PF)-Purkinje cell (PC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a73144d9a645fd589223678d489fb8
https://pubmed.ncbi.nlm.nih.gov/22864186

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