Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jan A van der Knaap"'
Autor:
Ben C Tilly, Gillian E Chalkley, Jan A van der Knaap, Yuri M Moshkin, Tsung Wai Kan, Dick HW Dekkers, Jeroen AA Demmers, C Peter Verrijzer
Publikováno v:
eLife, Vol 10 (2021)
ATP-dependent chromatin remodelers control the accessibility of genomic DNA through nucleosome mobilization. However, the dynamics of genome exploration by remodelers, and the role of ATP hydrolysis in this process remain unclear. We used live-cell i
Externí odkaz:
https://doaj.org/article/9127d0482a2844bc94f9f9006ff6118e
Autor:
Ayestha Sijm, Yaser Atlasi, Jan A. van der Knaap, Joyce Wolf van der Meer, Gillian E. Chalkley, Karel Bezstarosti, Dick H. W. Dekkers, Wouter A. S. Doff, Zeliha Ozgur, Wilfred F. J. van IJcken, Jeroen A. A. Demmers, C. Peter Verrijzer
Publikováno v:
Science advances, 8(44):abq7598. American Association for the Advancement of Science
Sijm, A, Atlasi, Y, van der Knaap, J A, van der Meer, J W, Chalkley, G E, Bezstarosti, K, Dekkers, D H W, Doff, W A S, Ozgur, Z, van IJcken, W F J, Demmers, J A A & Verrijzer, C P 2022, ' USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3 ', Science Advances, vol. 8, no. 44, abq7598 . https://doi.org/10.1126/sciadv.abq7598
Sijm, A, Atlasi, Y, van der Knaap, J A, van der Meer, J W, Chalkley, G E, Bezstarosti, K, Dekkers, D H W, Doff, W A S, Ozgur, Z, van IJcken, W F J, Demmers, J A A & Verrijzer, C P 2022, ' USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3 ', Science Advances, vol. 8, no. 44, abq7598 . https://doi.org/10.1126/sciadv.abq7598
Ubiquitin-specific protease 7 (USP7) has been implicated in cancer progression and neurodevelopment. However, its molecular targets remain poorly characterized. We combined quantitative proteomics, transcriptomics, and epigenomics to define the core
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8154b759994b52753de3c189ce8b3ce3
https://pubmed.ncbi.nlm.nih.gov/36332031
https://pubmed.ncbi.nlm.nih.gov/36332031
Autor:
C. Peter Verrijzer, Gillian E. Chalkley, Dick H. W. Dekkers, Tsung Wai Kan, Jan A. van der Knaap, B. C. Tilly, Yuri M. Moshkin, Jeroen Demmers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::985fdab51618810379092228fe452ac6
https://doi.org/10.7554/elife.69424.sa2
https://doi.org/10.7554/elife.69424.sa2
Autor:
Yuri M. Moshkin, Jan A. van der Knaap, Jeroen Demmers, Gillian E. Chalkley, B. C. Tilly, C. Peter Verrijzer, Tsung Wai Kan, Dick H. W. Dekkers
Publikováno v:
eLife, Vol 10 (2021)
eLife, 10:e69424. eLife Sciences Publications
eLife
eLife, 10:e69424. eLife Sciences Publications
eLife
ATP-dependent chromatin remodelers control the accessibility of genomic DNA through nucleosome mobilization. However, the dynamics of genome exploration by remodelers, and the role of ATP hydrolysis in this process remain unclear. We used live-cell i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0321568f648c5e8d6e51cef262d04e5e
https://doi.org/10.1101/2021.04.23.441173
https://doi.org/10.1101/2021.04.23.441173
Publikováno v:
Genes & Development. 30:2345-2369
To make the appropriate developmental decisions or maintain homeostasis, cells and organisms must coordinate the expression of their genome and metabolic state. However, the molecular mechanisms that relay environmental cues such as nutrient availabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567db0e3141dff7b45916ce7d5f7bf78
https://doi.org/10.1101/gad.289140.116
https://doi.org/10.1101/gad.289140.116
Autor:
B. A. Ashok Reddy, Jan A. van der Knaap, Adone Mohd-Sarip, Dick H. W. Dekkers, Jeroen Demmers, C. Peter Verrijzer, Alice G. M. Bot, Mieke Timmermans, John W.M. Martens
Publikováno v:
Molecular Cell, 53(3), 458-470. Cell Press
Nucleotide biosynthesis is fundamental to normal cell proliferation as well as to oncogenesis. Tumor suppressor p53, which prevents aberrant cell proliferation, is destabilized through ubiquitylation by MDM2. Ubiquitin-specific protease 7 (USP7) play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda389f3cd68218d21b67d7788ceb8d5
https://hdl.handle.net/1765/60122
https://hdl.handle.net/1765/60122
Autor:
Wilfred F. J. van IJcken, Zeliha Ozgur, Alexey V. Pindyurin, C. Peter Verrijzer, Yuri M. Moshkin, Jan A. van der Knaap, Elena N. Kozhevnikova
Publikováno v:
Molecular Cell, 47(1), 133-139. Cell Press
Cells need to coordinate gene expression and metabolic state. Inosine monophosphate dehydrogenase (IMPDH) controls the guanine nucleotide pool and, thereby, cell proliferation. We found that Drosophila IMPDH is also a DNA-binding transcriptional repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c34ff7e8b060fbefc9a5e1974dae726
Autor:
Yuri M. Moshkin, Jan A. van der Knaap, Karin Langenberg, Elena N. Kozhevnikova, C. Peter Verrijzer
Publikováno v:
Molecular and Cellular Biology, 30(3), 736-744. American Society for Microbiology
Drosophila GMP synthetase binds ubiquitin-specific protease 7 (USP7) and is required for its ability to deubiquitylate histone H2B. Previously, we showed that the GMPS/USP7 complex cooperates with the Polycomb silencing system through removal of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fe5ba636d54b48de865e52e8966999
https://doi.org/10.1128/mcb.01121-09
https://doi.org/10.1128/mcb.01121-09
Autor:
Andrew R. Bassett, Jeroen Demmers, Prashanth Kumar Bajpe, Andrew Travers, C. Peter Verrijzer, Heleen M.M. van Beusekom, Karel Bezstarosti, Jan A. van der Knaap
Publikováno v:
Molecular and Cellular Biology, 28(5), 1606-1615. American Society for Microbiology
Protein ubiquitylation plays a central role in multiple signal transduction pathways. However, the substrate specificity and potential developmental roles of deubiquitylating enzymes remain poorly understood. Here, we show that the Drosaphila ubiquit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41b95719b19cc5dcca70315afa5eaaa
https://hdl.handle.net/1765/29488
https://hdl.handle.net/1765/29488
Autor:
Jan A. VAN DER KNAAP, Vincent VAN DEN BOOM, Jeroen KUIPERS, Michiel J. T. VAN EIJK, Peter C. VAN DER VLIET, H. Th. Marc TIMMERS
Publikováno v:
Biochemical Journal. 345:521-527
The TATA-binding protein (TBP) plays a central role in eukaryotic transcription and forms protein complexes with TBP-associated factors (TAFs). The genes encoding TAFII proteins frequently map to chromosomal regions altered in human neoplasias. TAFII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748f5d09cb1a5a782ca5c3c0eeb51b75
https://doi.org/10.1042/bj3450521
https://doi.org/10.1042/bj3450521