Zobrazeno 1 - 10
of 622
pro vyhledávání: '"Jan A, Burger"'
Autor:
Melanie Schulz, Sanne Bleser, Manouk Groels, Dragan Bošnački, Jan A. Burger, Nicholas Chiorazzi, Carsten Marr
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111242- (2024)
Summary: The Bruton tyrosine kinase inhibitor ibrutinib is an effective treatment for patients with chronic lymphocytic leukemia (CLL). While it rapidly reduces lymph node and spleen size, it initially increases the number of lymphocytes in the blood
Externí odkaz:
https://doaj.org/article/ca44a0f8b44b420d87f0799f6f03ce19
Autor:
Paolo Ghia, Carolyn Owen, John N. Allan, Jacqueline C. Barrientos, Paul M. Barr, Chunxue Shi, Anita Szoke, Christopher Abbazio, Gabriel S. Krigsfeld, Jan A. Burger
Publikováno v:
HemaSphere, Vol 8, Iss 5, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/7de055e90fc7418daa0abd624f7c937e
Autor:
Firas M. Safa, Terri Rasmussen, Lorena Fontan, Min Xia, Ari Melnick, Adrian Wiestner, Patricia Lobelle-Rich, Jan A. Burger, Yara Mouawad, Hana Safah, Erik K. Flemington, Nakhle S. Saba
Publikováno v:
Haematologica, Vol 109, Iss 5 (2023)
B-cell acute lymphoblastic leukemia (B-ALL) remains a hard-to-treat disease with a poor prognosis in adults. Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a para-caspase required for B-cell receptor (BCR)-mediated NF-
Externí odkaz:
https://doaj.org/article/7a403361604b4b78a65a32aa7c2478d9
Autor:
Sultan Hassan, Eve C. Ostriker, Chang-Goo Kim, Greg L. Bryan, Jan D. Burger, Drummond B. Fielding, John C. Forbes, Shy Genel, Lars Hernquist, Sarah M. R. Jeffreson, Bhawna Motwani, Matthew C. Smith, Rachel S. Somerville, Ulrich P. Steinwandel, Romain Teyssier
Publikováno v:
The Astrophysical Journal, Vol 975, Iss 1, p 151 (2024)
Traditional star formation subgrid models implemented in cosmological galaxy formation simulations, such as that of V. Springel & L. Hernquist (hereafter SH03), employ adjustable parameters to satisfy constraints measured in the local Universe. In re
Externí odkaz:
https://doaj.org/article/3e91b06c21f8473198573bcc75620ca2
Publikováno v:
Leukemia Research Reports, Vol 20, Iss , Pp 100377- (2023)
Membranous nephropathy (MN) is an uncommon renal presentation in patients with chronic lymphocytic leukemia (CLL), and as such, there is no standard therapy for these patients. A few cases of MN in CLL have been described with varying success in MN t
Externí odkaz:
https://doaj.org/article/be111f20ca524f1b9fe105add5ea7eb3
Autor:
Rong Chen, Jennifer Tsai, Philip A. Thompson, Yuling Chen, Ping Xiong, Chaomei Liu, Francis Burrows, Mariela Sivina, Jan A. Burger, Michael J. Keating, William G. Wierda, William Plunkett
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 3, Pp 1-15 (2021)
Abstract The constitutive activation of B-cell receptor (BCR) signaling, together with the overexpression of the Bcl-2 family anti-apoptotic proteins, represents two hallmarks of chronic lymphocytic leukemia (CLL) that drive leukemia cell proliferati
Externí odkaz:
https://doaj.org/article/c1c1b56b91374e5199779633b84aeb68
Autor:
Andrea N. Mazzarello, Eva Gentner-Göbel, Marcus Dühren-von Minden, Tatyana N. Tarasenko, Antonella Nicolò, Gerardo Ferrer, Stefano Vergani, Yun Liu, Davide Bagnara, Kanti R. Rai, Jan A. Burger, Peter J. McGuire, Palash C. Maity, Hassan Jumaa, Nicholas Chiorazzi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
In chronic lymphocytic leukemia (CLL), the B cell receptor (BCR) plays a critical role in disease development and progression, as indicated by the therapeutic efficacy of drugs blocking BCR signaling. However, the mechanism(s) underlying BCR responsi
Externí odkaz:
https://doaj.org/article/66a5d21ed217411b9bb0675bdc0e82e4
Autor:
C. I. Edvard Smith, Jan A. Burger
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Since the first clinical report in 2013, inhibitors of the intracellular kinase BTK (BTKi) have profoundly altered the treatment paradigm of B cell malignancies, replacing chemotherapy with targeted agents in patients with chronic lymphocytic leukemi
Externí odkaz:
https://doaj.org/article/8281dd100abd4748bb6bc09bf62a84a1
Autor:
Jan A. Burger
Publikováno v:
Precision Cancer Therapies, Volume 1 ‐ Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies. :249-267
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e181a4011ad941cfc5ec71c1f75ec5b
https://doi.org/10.1002/9781119819950.ch18
https://doi.org/10.1002/9781119819950.ch18
Autor:
Paul M Barr, Carolyn Owen, Tadeusz Robak, Alessandra Tedeschi, Osnat Bairey, Jan A Burger, Peter Hillmen, Claire Dearden, Sebastian Grosicki, Helen McCarthy, Jian Yong Li, Fritz Offner, Carol Moreno, Mandy Jermain, Cathy Zhou, Emily Hsu, Anita Szoke, Thomas J Kipps, Paolo Ghia
Publikováno v:
Future Oncology. 18:4047-4057
What is this summary about? This is a plain language summary of a publication describing long-term results from the RESONATE-2 study with up to 8 years of follow-up. The original paper was published in Blood Advances in June 2022. What were the resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dff542a7c871a86dad35e9e45d685bd
https://doi.org/10.2217/fon-2022-0898
https://doi.org/10.2217/fon-2022-0898