Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jan zur Megede"'
Autor:
Diane Hebblewaite, Peter Silvera, Jan zur Megede, Dawn Golightly, John J. Donnelly, Brigitte E Sanders-Beer, Jeffrey B. Ulmer, Ranjana Srivastava, Susan W. Barnett, Abigail Bowlsbey, Dietmar Rabussay, Gillis R. Otten, Lei Zhang, Lourdes Nieves-Duran, Deborah Sites
Publikováno v:
AIDS Research and Human Retroviruses. 24:1103-1116
The immunologic and virologic outcome of therapeutic DNA-vaccines administered during antiretroviral therapy (ART) using electroporation with or without (interleukin) IL-2 treatment was evaluated in the SIV-mac239/macaque model. Rhesus macaques inocu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab915dede18c729bc880af9ca2dc1343
https://doi.org/10.1089/aid.2008.0055
https://doi.org/10.1089/aid.2008.0055
Autor:
Jan zur Megede, Manmohan Singh, José A. Melero, Derek T. O'Hagan, Rebecca Helson, Wieslawa Olszewska, Peter J. M. Openshaw
Publikováno v:
Vaccine. 26:753-761
Priming with the major surface glycoprotein G of respiratory syncytial virus (RSV) expressed by recombinant vaccinia leads to strong Th2 responses and lung eosinophilia during viral challenge. We now show that DNA vaccination in BALB/c mice with plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7045150f76808622c2e13bc6ccdc18c
https://doi.org/10.1016/j.vaccine.2007.12.006
https://doi.org/10.1016/j.vaccine.2007.12.006
Autor:
Fengmin Zhou, Tony Tang, Harold Legg, Paul A. Luciw, Jan zur Megede, Derek T. O'Hagan, Michael Vajdy, Susan W. Barnett, John M. Polo, Catherine Greer, John J. Donnelly, Soumi Gupta
Publikováno v:
AIDS Research and Human Retroviruses. 22:993-997
Mucosal and systemic transmission of HIV is prevalent. Therefore, mucosal followed by parenteral immunizations with chimeric vs. complete alphavirus-based replicon particles, encoding an HIV envelope glycoprotein, were tested. Female rhesus macaques
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ca7b38eb2359ae4676e3ac288f5b3a
https://doi.org/10.1089/aid.2006.22.993
https://doi.org/10.1089/aid.2006.22.993
Autor:
Lingmei Ding, Susan W. Barnett, Paul Spearman, Timothy R. Fouts, Jan zur Megede, Anthony De Vico, Jason Hammonds, Xuemin Chen
Publikováno v:
Virology. 314:636-649
Human immunodeficiency virus type-1 (HIV-1) particles incorporate a trimeric envelope complex (Env) made of gp120 (SU) and gp41 (TM) heterodimers. It has been previously established that soluble CD4 (sCD4) interaction leads to shedding of gp120 from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eaa1295c3965bb87ee9922a028e531c
https://doi.org/10.1016/s0042-6822(03)00467-7
https://doi.org/10.1016/s0042-6822(03)00467-7
Autor:
Jan zur Megede, Barbara Doe, Minchao Chen, Susan W. Barnett, Gillis R. Otten, Jeffrey B. Ulmer
Publikováno v:
Immunology Letters. 85:215-222
An effective HIV vaccine will likely need to induce potent and broad-based immunity, including CD8+ T cell responses. Hence, a quantitative assay to measure such responses in animal models will be important in the evaluation of candidate HIV vaccines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7caa154ac7eafb323fb19666759a4f55
https://doi.org/10.1016/s0165-2478(02)00237-7
https://doi.org/10.1016/s0165-2478(02)00237-7
Autor:
Jan zur Megede, Sharon Cassol, Susan W. Barnett, Estrelita Janse van Rensburg, Tulio de Oliveira, Thomas J. Scriba, Susan Engelbrecht
Publikováno v:
AIDS Research and Human Retroviruses. 18:1327-1332
Understanding the origin, distribution, and evolving dominance of HIV-1 subtype C strains is an important component in the design and evaluation of a globally effective AIDS vaccine. To better understand subtype C viruses, we constructed complete mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf85e6774b45a0da79cb394a7f5f259
https://doi.org/10.1089/088922202320886370
https://doi.org/10.1089/088922202320886370
Autor:
Stephen Norley, Thorsten U. Vogel, Reinhard Kurth, Silke Holzammer, Hans-Georg Ihlenfeldt, Günther Jung, John D. Altman, Brigitte Beer, Jan zur Megede, David I. Watkins
Publikováno v:
Journal of General Virology. 83:81-91
Lipopeptides which carry the N-terminal moiety tripalmitoyl-S-glyceryl-cysteinyl-seryl-seryl (P3CSS) have been shown to have effective adjuvant and transmembrane carrier properties. To test the ability of these constructs to immunize against simian i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb9b85c7831d1e100579212d82d2201
https://doi.org/10.1099/0022-1317-83-1-81
https://doi.org/10.1099/0022-1317-83-1-81
Autor:
Candice C. Sampson, Tania de Villiers, Susan Engelbrecht, Susan W. Barnett, Jan zur Megede, Estrelita Janse van Rensburg
Publikováno v:
AIDS Research and Human Retroviruses. 17:1533-1547
South Africa has one of the fastest growing HIV-1 epidemics, with an estimated 4.7 million people infected. To better understand the genetic diversity of this epidemic and its potential impact on vaccine development, we have cloned and sequenced the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62f9922d41659c3efb1734d0d718542
https://doi.org/10.1089/08892220152644241
https://doi.org/10.1089/08892220152644241
Autor:
John M. Polo, David A. Driver, Gillis R. Otten, Margaret A. Liu, Mary Lee MacKichan, Susan W. Barnett, Jason P. Gardner, Ilya Frolov, Barbara A. Belli, Minchao Chen, Jan zur Megede, Silvia Perri, Yaying Ji, Thomas W. Dubensky, Catherine Greer, Scott Sherrill
Publikováno v:
Journal of Virology. 74:11849-11857
The ability to target antigen-presenting cells with vectors encoding desired antigens holds the promise of potent prophylactic and therapeutic vaccines for infectious diseases and cancer. Toward this goal, we derived variants of the prototype alphavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50dcb3f779cdbaecf9d134af0e967da9
https://doi.org/10.1128/jvi.74.24.11849-11857.2000
https://doi.org/10.1128/jvi.74.24.11849-11857.2000
Autor:
Jan zur Megede, Barbara Doe, Catherine Greer, Gillis R. Otten, Susan W. Barnett, Mark Selby, Minchao Chen, Mary Schaefer
Publikováno v:
Journal of Virology. 74:2628-2635
The induction of long-lasting, potent humoral and cellular immune responses will be important for an effective human immunodeficiency virus (HIV) vaccine. Data from HIV-infected patients, and in particular from long-term nonprogressors, have shown th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4888d8140b7caee91a0cea99e01259eb
https://doi.org/10.1128/jvi.74.6.2628-2635.2000
https://doi.org/10.1128/jvi.74.6.2628-2635.2000