Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Jan Kehler"'
Autor:
Sigrid Marie Blom, Mario Rottländer, Jan Kehler, Christoffer Bundgaard, Nicole Schmitt, Henrik Sindal Jensen
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100209 (2014)
The voltage-gated potassium channels of the KV7 family (KV7.1-5) play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability. One of the main challenges in
Externí odkaz:
https://doaj.org/article/13c242eb117543f791c6da46c8b50c06
Autor:
Lars Kyhn Rasmussen, Jan Kehler, Elin Eneberg, Todor V. Gerdjikov, Jesper F. Bastlund, Jessica Hayes, Morten Langgård, Bettina Laursen
Publikováno v:
Neuropharmacology. 186
Positive modulation of cAMP signalling by phosphodiesterase (PDE) inhibitors has recently been explored as a potential target for the reversal of cognitive and behavioural deficits implicating the corticoaccumbal circuit. Previous studies show that P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b597c388792164dc058ff27f11820f7f
https://pubmed.ncbi.nlm.nih.gov/33444639
https://pubmed.ncbi.nlm.nih.gov/33444639
Autor:
Alejandro, Castán, Ramón, Badorrey, José A, Díez, Claus T, Christoffersen, Lars K, Rasmussen, Jan, Kehler, Ralf, Köhler, José A, Gálvez, María D, Díaz-de-Villegas
Publikováno v:
The Journal of organic chemistry. 85(9)
Two series of novel chiral hexahydro-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::57c3c0319bc75bcaf7501e2b68074278
https://pubmed.ncbi.nlm.nih.gov/32248689
https://pubmed.ncbi.nlm.nih.gov/32248689
Autor:
Ralf Köhler, José María Abad Díez, Lars Kyhn Rasmussen, María D. Díaz-de-Villegas, Jan Kehler, Claus Tornby Christoffersen, Alejandro Castán, José A. Gálvez, Ramón Badorrey
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Two series of novel chiral hexahydro-2H-furo[3,2-b]pyrroles, 4-(7,8-dimethoxyquinazolin-4-yl) series A and 4-(6,7- dimethoxyquinazolin-4-yl) series B, were synthesized in enantiomerically pure form and evaluated for their inhibitory effects on phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04d1dd40bc2fd5623e30b52a4b5d555
http://hdl.handle.net/10261/220552
http://hdl.handle.net/10261/220552
Autor:
Rasmus P. Clausen, Claus H. Jensen, Sara Björk Sigurdardóttir, Kenneth T. Kongstad, David E. Gloriam, Petrine Wellendorph, Mia Nittegaard-Nielsen, Christina Birkedahl Falk-Petersen, Francesco Bavo, Yongsong Tian, Jan Kehler, Kasper Harpsøe, Jacob Krall, Stine B. Vogensen, Bente Frølund, Anne S. Haugaard
Publikováno v:
Journal of Medicinal Chemistry. 60:9022-9039
γ-hydroxybutyric acid (GHB) is a neuroactive substance with specific high-affinity binding sites. To facilitate target identification and ligand optimization, we herein report a comprehensive structure-affinity relationship study for novel ligands t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371f91bb7a8a910a778dba45c5ffc706
https://doi.org/10.1021/acs.jmedchem.7b01351
https://doi.org/10.1021/acs.jmedchem.7b01351
Autor:
Jacob Nielsen, Thomas Dalsgaard, Dorte Clausen, Lasse Folkersen, Lars Kyhn Rasmussen, Makhala M. Khammy, Claus Tornby Christoffersen, Peter Hjørringgaard Larsen, Morten Grunnet, Jan Kehler, Christian Aalkjaer
Publikováno v:
British Journal of Pharmacology. 174:4186-4198
Background and Purpose PDE1, a subfamily of cyclic nucleotide PDEs consisting of three isoforms, PDE1A, PDE1B and PDE1C, has been implicated in the regulation of vascular tone. The PDE1 isoform(s) responsible for tone regulation is unknown. This stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bed48d77c724ef4e0d3657e422ae2bcb
https://doi.org/10.1111/bph.14034
https://doi.org/10.1111/bph.14034
Autor:
Ulf Simonsen, Christoffer Bundgaard, Tomas Mow, Susie Mogensen, Estéfano Pinilla, Morten Grunnet, Jan Kehler, Morten Laursen, Claus Tornby Christoffersen, Lilliana Beck, Jakob S. Knudsen, Elise R. Hedegaard
Publikováno v:
British Journal of Pharmacology. 174:2563-2575
Background and purpose Phosphodiesterase enzymes (PDE1-11) break down cyclic nucleotides and are important in the regulation of the cardiovascular system. The purpose of the present study was to investigate the effect on the cardiovascular system of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdd379087ddb01a34b9b4760977398c2
https://doi.org/10.1111/bph.13868
https://doi.org/10.1111/bph.13868
Autor:
Sebastian Leth-Petersen, Hans Bräuner-Osborne, Christoffer Bundgaard, John D. McCorvy, Jesper L. Kristensen, Jan Kehler, Anders A. Jensen, Terry P. Kenakin, Gudrun Liebscher
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:441-453
Therapeutic interest in augmentation of 5-hydroxytryptamine2A (5-HT2A) receptor signaling has been renewed by the effectiveness of psychedelic drugs in the treatment of various psychiatric conditions. In this study, we have further characterized the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35e10d89ac28ecf5f871e1557a08469c
https://doi.org/10.1124/jpet.117.239905
https://doi.org/10.1124/jpet.117.239905
Publikováno v:
Tetrahedron. 73:1576-1582
Morpholine amides are cheap and safe alternative to Weinreb amides as acylating agents of organometallic species. Herein, the in-situ lithiation/borylation of 18 ortho- meta- and para-substituted morpholine benzamides has been investigated. 10 of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c296a63832bc5ee4474ab30ba3452a6
https://doi.org/10.1016/j.tet.2017.02.002
https://doi.org/10.1016/j.tet.2017.02.002
Autor:
Oliver Griesbeck, Dahdjim Betolngar, Jan Kehler, Liliana R. V. Castro, Charlotte Hougaard, Pierre Vincent, Jun Yang, Élia Mota, Arne Fabritius, Claus Tornby Christoffersen, Jacob Nielsen
Publikováno v:
Cerebral Cortex
Cerebral Cortex, 2019, Epub ahead of print. ⟨10.1093/cercor/bhz041⟩
Cerebral Cortex, Oxford University Press (OUP), 2019, Epub ahead of print. ⟨10.1093/cercor/bhz041⟩
Cerebral Cortex, 2019, Epub ahead of print. ⟨10.1093/cercor/bhz041⟩
Cerebral Cortex, Oxford University Press (OUP), 2019, Epub ahead of print. ⟨10.1093/cercor/bhz041⟩
The calcium-regulated phosphodiesterase 1 (PDE1) family is highly expressed in the brain, but its functional role in neurones is poorly understood. Using the selective PDE1 inhibitor Lu AF64196 and biosensors for cyclic nucleotides including a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f58574bad650f7c419ae1faba3dcbb1
https://hdl.handle.net/21.11116/0000-0006-E090-921.11116/0000-0006-E091-821.11116/0000-0005-BCFD-B
https://hdl.handle.net/21.11116/0000-0006-E090-921.11116/0000-0006-E091-821.11116/0000-0005-BCFD-B