Zobrazeno 1 - 10 of 113 pro vyhledávání: '"Jan Abendroth"'
2
Akademický článek
Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site
Autor: Seyed Mohammad Ghafoori, Gayle F. Petersen, Deborah G. Conrady, Brandy M. Calhoun, Matthew Z. Z. Stigliano, Ruth O. Baydo, Rena Grice, Jan Abendroth, Donald D. Lorimer, Thomas E. Edwards, Jade K. Forwood
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Influenza virus (IV) causes several outbreaks of the flu each year resulting in an economic burden to the healthcare system in the billions of dollars. Several influenza pandemics have occurred during the last century and estimated to have c
Externí odkaz: https://doaj.org/article/76d2ef5b49eb4543ad2cf4338202406a
Zobrazit plný text záznamu
3
Akademický článek
Aconitate decarboxylase 1 participates in the control of pulmonary Brucella infection in mice.
Autor: Aurore Demars, Armelle Vitali, Audrey Comein, Elodie Carlier, Abdulkader Azouz, Stanislas Goriely, Justine Smout, Véronique Flamand, Mégane Van Gysel, Johan Wouters, Jan Abendroth, Thomas E Edwards, Arnaud Machelart, Eik Hoffmann, Priscille Brodin, Xavier De Bolle, Eric Muraille
Publikováno v: PLoS Pathogens, Vol 17, Iss 9, p e1009887 (2021)
Brucellosis is one of the most widespread bacterial zoonoses worldwide. Here, our aim was to identify the effector mechanisms controlling the early stages of intranasal infection with Brucella in C57BL/6 mice. During the first 48 hours of infection,
Externí odkaz: https://doaj.org/article/0ebdeb0dee1242609d7b967c5f88f4d6
Zobrazit plný text záznamu
4
Bacterial structural genomics target enabled by a recently discovered potent fungal acetyl-CoA synthetase inhibitor
Autor: Nicholas D. DeBouver, Madison J. Bolejack, Taiwo E. Esan, Damian J. Krysan, Timothy J. Hagen, Jan Abendroth
Publikováno v: Acta Crystallographica Section F Structural Biology Communications. 79:137-143
The compound ethyl-adenosyl monophosphate ester (ethyl-AMP) has been shown to effectively inhibit acetyl-CoA synthetase (ACS) enzymes and to facilitate the crystallization of fungal ACS enzymes in various contexts. In this study, the addition of ethy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddaf2bcf56d804e8430cfa56c5c44959
https://doi.org/10.1107/s2053230x23003801
Zobrazit plný text záznamu
5
Akademický článek
Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba.
Autor: Logan Tillery, Kayleigh Barrett, Jenna Goldstein, Jared W Lassner, Bram Osterhout, Nathan L Tran, Lily Xu, Ryan M Young, Justin Craig, Ian Chun, David M Dranow, Jan Abendroth, Silvia L Delker, Douglas R Davies, Stephen J Mayclin, Brandy Calhoun, Madison J Bolejack, Bart Staker, Sandhya Subramanian, Isabelle Phan, Donald D Lorimer, Peter J Myler, Thomas E Edwards, Dennis E Kyle, Christopher A Rice, James C Morris, James W Leahy, Roman Manetsch, Lynn K Barrett, Craig L Smith, Wesley C Van Voorhis
Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0241738 (2021)
Naegleria fowleri is a pathogenic, thermophilic, free-living amoeba which causes primary amebic meningoencephalitis (PAM). Penetrating the olfactory mucosa, the brain-eating amoeba travels along the olfactory nerves, burrowing through the cribriform
Externí odkaz: https://doaj.org/article/23d070499b154d11aa93fd5498f6c574
Zobrazit plný text záznamu
8
In Vitro and In Vivo Efficacy of NITD-916 against Mycobacterium fortuitum
Autor: Françoise Roquet-Banères, Matthéo Alcaraz, Claire Hamela, Jan Abendroth, Thomas E. Edwards, Laurent Kremer
Publikováno v: Antimicrobial Agents and Chemotherapy. 67
Mycobacterium fortuitum represents one of the most clinically relevant rapid-growing mycobacterial species. Treatments are complex due to antibiotic resistance and to severe side effects of effective drugs, prolonged time of treatment, and co-infecti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e8f4d5014d686c97869df9fe7a9c0d2
https://doi.org/10.1128/aac.01607-22
Zobrazit plný text záznamu
9
Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1
Autor: Adrian Hall, Jan Abendroth, Madison J. Bolejack, Tom Ceska, Sylvie Dell’Aiera, Victoria Ellis, David Fox, Cyril François, Muigai M. Muruthi, Camille Prével, Karine Poullennec, Sergei Romanov, Anne Valade, Alain Vanbellinghen, Jason Yano, Martine Geraerts
Publikováno v: ACS Medicinal Chemistry Letters. 13:1099-1108
We describe the identification and characterization of a series of covalent inhibitors of the C-terminal kinase domain (CTKD) of MSK1. The initial hit was identified via a high-throughput screening and represents a rare example of a covalent inhibito
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a0207a67876bf40c7c83d5e98d0f32
https://doi.org/10.1021/acsmedchemlett.2c00134
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje