Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jan Štourač"'
Autor:
Rayyan Tariq Khan, Petra Pokorna, Jan Stourac, Simeon Borko, Adam Dobias, Joan Planas-Iglesias, Stanislav Mazurenko, Ihor Arefiev, Gaspar Pinto, Veronika Szotkowska, Jaroslav Sterba, Jiri Damborsky, Ondrej Slaby, David Bednar
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 24, Iss , Pp 734-738 (2024)
Next-generation sequencing technology has created many new opportunities for clinical diagnostics, but it faces the challenge of functional annotation of identified mutations. Various algorithms have been developed to predict the impact of missense v
Externí odkaz:
https://doaj.org/article/3d4ec3367bee4e13870e203cd22157b5
Autor:
Jaroslav Bendl, Jan Stourac, Ondrej Salanda, Antonin Pavelka, Eric D Wieben, Jaroslav Zendulka, Jan Brezovsky, Jiri Damborsky
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 1, p e1003440 (2014)
Single nucleotide variants represent a prevalent form of genetic variation. Mutations in the coding regions are frequently associated with the development of various genetic diseases. Computational tools for the prediction of the effects of mutations
Externí odkaz:
https://doaj.org/article/9927d237602e4578875b61bebe185588
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 5, p e1004962 (2016)
An important message taken from human genome sequencing projects is that the human population exhibits approximately 99.9% genetic similarity. Variations in the remaining parts of the genome determine our identity, trace our history and reveal our he
Externí odkaz:
https://doaj.org/article/d3356687e4354f20bce11cb914615117
Autor:
Rayyan Tariq Khan, Petra Pokorna, Jan Stourac, Simeon Borko, Ihor Arefiev, Joan Planas-Iglesias, Adam Dobias, Gaspar Pinto, Veronika Szotkowska, Jaroslav Sterba, Ondrej Slaby, Jiri Damborsky, Stanislav Mazurenko, David Bednar
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Every year, more than 19 million cancer cases are diagnosed, and this number continues to increase annually. Since standard treatment options have varying success rates for different types of cancer, understanding the biology of an individua
Externí odkaz:
https://doaj.org/article/138a77a9475c4a66973983bff91f0986
Autor:
Milos Musil, Andrej Jezik, Marie Jankujova, Jan Stourac, Jakub Galgonek, Saltuk Mustafa Eyrilmez, Jiri Vondrasek, Jiri Damborsky, David Bednar
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6512-6518 (2022)
Protein tunnels are essential in transporting small molecules into the active sites of enzymes. Tunnels' geometrical and physico-chemical properties influence the transport process. The tunnels are attractive hot spots for protein engineering and dru
Externí odkaz:
https://doaj.org/article/14aa7edb75b64030812052db2895149c
Autor:
Jan Velecký, Marie Hamsikova, Jan Stourac, Milos Musil, Jiri Damborsky, David Bednar, Stanislav Mazurenko
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6339-6347 (2022)
Protein solubility is an attractive engineering target primarily due to its relation to yields in protein production and manufacturing. Moreover, better knowledge of the mutational effects on protein solubility could connect several serious human dis
Externí odkaz:
https://doaj.org/article/01996fd690c34e7e8edd9de1f51b18d1
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Protein tunnels and channels are attractive targets for drug design. Drug molecules that block the access of substrates or release of products can be efficient modulators of biological activity. Here, we demonstrate the applicability of a newly devel
Externí odkaz:
https://doaj.org/article/ea3750d1ca4041ce86e094f53dac33b2
Autor:
Haydee Artaza, Neil Chue Hong, Manuel Corpas, Angel Corpuz, Rob Hooft, Rafael C. Jimenez, Brane Leskošek, Brett G. Olivier, Jan Stourac, Radka Svobodová Vařeková, Thomas Van Parys, Daniel Vaughan
Publikováno v:
F1000Research, Vol 5 (2016)
Metrics for assessing adoption of good development practices are a useful way to ensure that software is sustainable, reusable and functional. Sustainability means that the software used today will be available - and continue to be improved and suppo
Externí odkaz:
https://doaj.org/article/2e7b172f4ba546acaf58f11cd4859fca