Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jan Škerle"'
Autor:
Jan Dohnálek, Nicholas Johnson, Kvido Strisovsky, Jan Škerle, Jana Humpolíčková, David Jakubec, Edita Poláchová, Anna Suchánková, Petra Rampírová, Monika Fliegl
Publikováno v:
Biophys J
Many membrane proteins are thought to function as dimers or higher oligomers, but measuring membrane protein oligomerization in lipid membranes is particularly challenging. Forster resonance energy transfer (FRET) and fluorescence cross-correlation s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579783605fb408b3b988bd7b3c1837aa
https://europepmc.org/articles/PMC7175701/
https://europepmc.org/articles/PMC7175701/
Autor:
David Jakubec, Kvido Strisovsky, Jan Škerle, Petra Rampírová, Adámková L, Jana Humpolíčková, Anna Suchánková, Edita Poláchová
Many membrane proteins are thought to function as oligomers, but measuring membrane protein dimerization in native lipid membranes is particularly challenging. Förster resonance energy transfer (FRET) and fluorescence correlation spectroscopy (FCS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f6f1f946b70825b37ea96a43172a4f
Autor:
Jakub Began, Stancho Stanchev, Martin Lepšík, Darren C. Johnson, Kutti R. Vinothkumar, Pavel Majer, Anežka Tichá, Minh T.N. Nguyen, Daniel A. Bachovchin, Steven H. L. Verhelst, Petr Pachl, Kvido Strisovsky, Jan Škerle, Kateřina Švehlová, David C. Mikles
Publikováno v:
Cell chemical biology. 24(12)
Rhomboid-family intramembrane proteases regulate important biological processes and have been associated with malaria, cancer, and Parkinson's disease. However, due to the lack of potent, selective, and pharmacologically compliant inhibitors, the wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db24dd6fb4a06ecc913f0b68b529d3c
https://pubmed.ncbi.nlm.nih.gov/29272699
https://pubmed.ncbi.nlm.nih.gov/29272699
Autor:
Anežka Tichá, Marek Ingr, Romana Hadravová, Edita Poláchová, Kateřina Švehlová, Lucie Bednárová, Lucie Polovinkin, Martin Růžička, Václav Kašička, Petra Rampírová, Pavel Majer, Stancho Stanchev, Jakub Began, Jana Březinová, Kvido Strisovsky, Jan Škerle
Rhomboid proteases are increasingly being explored as potential drug targets, but their potent and specific inhibitors are not available, and strategies for inhibitor development are hampered by the lack of widely usable and easily modifiable in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ad4d924f9cbd9e7bb0a23a9131ce08
https://europepmc.org/articles/PMC5314168/
https://europepmc.org/articles/PMC5314168/
Autor:
Lucie Peclinovská, Kvido Strisovsky, Jan Škerle, Jakub Began, Stancho Stanchev, Pavel Majer, Sebastian Zoll, Martin Lepšík
Publikováno v:
The EMBO Journal
The mechanisms of intramembrane proteases are incompletely understood due to the lack of structural data on substrate complexes. To gain insight into substrate binding by rhomboid proteases, we have synthesised a series of novel peptidyl-chloromethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31103110ececfa70a022086c8c482a0
http://europepmc.org/articles/PMC4253528
http://europepmc.org/articles/PMC4253528