Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Jan‑Michael Peters"'
Autor:
Ignacio Prusén Mota, Marta Galova, Alexander Schleiffer, Tan-Trung Nguyen, Ines Kovacikova, Carolina Farias Saad, Gabriele Litos, Tomoko Nishiyama, Juraj Gregan, Jan-Michael Peters, Peter Schlögelhofer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Cohesin mediates sister chromatid cohesion to enable chromosome segregation and DNA damage repair. To perform these functions, cohesin needs to be protected from WAPL, which otherwise releases cohesin from DNA. It has been proposed that cohe
Externí odkaz:
https://doaj.org/article/d6beb90833be42e5b425db97ffa8579c
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Spatial organization of DNA is facilitated by cohesin protein complexes that move on DNA and extrude DNA loops. How cohesin works mechanistically as a molecular machine is poorly understood. Here, we measure mechanical forces generated by co
Externí odkaz:
https://doaj.org/article/e2b3eaec54744081b323c40656deb72c
Autor:
Roman Barth, Biswajit Pradhan, Eugene Kim, Iain F. Davidson, Jaco van der Torre, Jan-Michael Peters, Cees Dekker
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract DNA loop extrusion by structural-maintenance-of-chromosome (SMC) complexes has emerged as a primary organizing principle for chromosomes. The mechanism by which SMC motor proteins extrude DNA loops is still unresolved and much debated. The r
Externí odkaz:
https://doaj.org/article/12547bab05c54d948ad59bec6503ca6b
Autor:
Louisa Hill, Gordana Wutz, Markus Jaritz, Hiromi Tagoh, Lesly Calderón, Jan-Michael Peters, Anton Goloborodko, Meinrad Busslinger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Extended loop extrusion across the immunoglobulin heavy-chain (Igh) locus facilitates VH-DJH recombination following downregulation of the cohesin-release factor Wapl by Pax5, resulting in global changes in the chromosomal architecture of pr
Externí odkaz:
https://doaj.org/article/edf04dd86f1b489984ce1a28653821b3
Autor:
Roman Barth, Biswajit Pradhan, Eugene Kim, Iain F. Davidson, Jaco van der Torre, Jan‑Michael Peters, Cees Dekker
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/c173b80b0c254e0184a119d15c898acc
Autor:
Adar Sonn-Segev, Katarina Belacic, Tatyana Bodrug, Gavin Young, Ryan T. VanderLinden, Brenda A. Schulman, Johannes Schimpf, Thorsten Friedrich, Phat Vinh Dip, Thomas U. Schwartz, Benedikt Bauer, Jan-Michael Peters, Weston B. Struwe, Justin L. P. Benesch, Nicholas G. Brown, David Haselbach, Philipp Kukura
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Mass photometry is a label-free optical approach capable of detecting, imaging and accurately measuring the mass of single biomolecules in solution. Here, the authors demonstrate the potential of mass photometry for quantitatively characterizing samp
Externí odkaz:
https://doaj.org/article/64c64280b6c2419aa33abdbde3459820
Autor:
Gordana Wutz, Rene Ladurner, Brian Glenn St Hilaire, Roman R Stocsits, Kota Nagasaka, Benoit Pignard, Adrian Sanborn, Wen Tang, Csilla Várnai, Miroslav P Ivanov, Stefan Schoenfelder, Petra van der Lelij, Xingfan Huang, Gerhard Dürnberger, Elisabeth Roitinger, Karl Mechtler, Iain Finley Davidson, Peter Fraser, Erez Lieberman-Aiden, Jan-Michael Peters
Publikováno v:
eLife, Vol 9 (2020)
Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL. Although WAPL limits cohesin’s chromatin
Externí odkaz:
https://doaj.org/article/50f9b518193c4de2ba8e04afd984547d
Autor:
Johann Holzmann, Antonio Z Politi, Kota Nagasaka, Merle Hantsche-Grininger, Nike Walther, Birgit Koch, Johannes Fuchs, Gerhard Dürnberger, Wen Tang, Rene Ladurner, Roman R Stocsits, Georg A Busslinger, Béla Novák, Karl Mechtler, Iain Finley Davidson, Jan Ellenberg, Jan-Michael Peters
Publikováno v:
eLife, Vol 8 (2019)
The organisation of mammalian genomes into loops and topologically associating domains (TADs) contributes to chromatin structure, gene expression and recombination. TADs and many loops are formed by cohesin and positioned by CTCF. In proliferating ce
Externí odkaz:
https://doaj.org/article/b4dd695cfba54d39a1aacd86fcfa079a
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells
Autor:
Simone Lieb, Silvia Blaha-Ostermann, Elisabeth Kamper, Janine Rippka, Cornelia Schwarz, Katharina Ehrenhöfer-Wölfer, Andreas Schlattl, Andreas Wernitznig, Jesse J Lipp, Kota Nagasaka, Petra van der Lelij, Gerd Bader, Minoru Koi, Ajay Goel, Ralph A Neumüller, Jan-Michael Peters, Norbert Kraut, Mark A Pearson, Mark Petronczki, Simon Wöhrle
Publikováno v:
eLife, Vol 8 (2019)
Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent functional screening data of cancer cell lines we identify Werner syndrome helicase (WRN) as a novel specific vulnerability of microsatellite i
Externí odkaz:
https://doaj.org/article/bcf5373f995c49dd883a2b357adfa700
Autor:
Michael T. Hons, Pim J. Huis in ‘t Veld, Jan Kaesler, Pascaline Rombaut, Alexander Schleiffer, Franz Herzog, Holger Stark, Jan-Michael Peters
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Cohesin is a ring-shaped protein complex that structures chromatin and mediates sister chromatid cohesion. Here the authors rigidify cohesin using engineered Smc1 and Smc3 and generated 3D models showing how Pds5B forms an integral part of the cohesi
Externí odkaz:
https://doaj.org/article/0f7233fdcb064b2d901ef3b4d2d7f3bf