Zobrazeno 1 - 10 of 87 pro vyhledávání: '"Jan, Stursa"'
1
Akademický článek
NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation
Autor: Sukanya B. Jadhav, Michaela Vondrackova, Petra Potomova, Cristian Sandoval-Acuña, Jana Smigova, Kristyna Klanicova, Daniel Rosel, Jan Brabek, Jan Stursa, Lukas Werner, Jaroslav Truksa
Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)
Multiple studies indicate that iron chelators enhance their anti-cancer properties by inducing NDRG1, a known tumor and metastasis suppressor. However, the exact role of NDRG1 remains controversial, as newer studies have shown that NDRG1 can also act
Externí odkaz: https://doaj.org/article/babf7f9ee7ce45d2aa4ee3ab2d7ec896
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2
Akademický článek
Mitochondrially targeted tamoxifen as anticancer therapy: case series of patients with renal cell carcinoma treated in a phase I/Ib clinical trial
Autor: Zuzana Bielcikova, Lukas Werner, Jan Stursa, Vladimir Cerny, Ludmila Krizova, Jan Spacek, Stanislav Hlousek, Michal Vocka, Olga Bartosova, Michal Pesta, Katarina Kolostova, Petr Klezl, Vladimir Bobek, Jaroslav Truksa, Sona Stemberkova-Hubackova, Lubos Petruzelka, Pavel Michalek, Jiri Neuzil
Publikováno v: Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Mitochondrially targeted anticancer drugs (mitocans) that disrupt the energy-producing systems of cancer are emerging as new potential therapeutics. Mitochondrially targeted tamoxifen (MitoTam), an inhibitor of mitochondrial respiration respiratory c
Externí odkaz: https://doaj.org/article/269f239884f64e4ea206c5d48ff311b3
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3
Akademický článek
Mitochondrially targeted tamoxifen in patients with metastatic solid tumours: an open-label, phase I/Ib single-centre trialResearch in context
Autor: Zuzana Bielcikova, Jan Stursa, Ludmila Krizova, Lanfeng Dong, Jan Spacek, Stanislav Hlousek, Michal Vocka, Katerina Rohlenova, Olga Bartosova, Vladimir Cerny, Tomas Padrta, Michal Pesta, Pavel Michalek, Sona Stemberkova Hubackova, Katarina Kolostova, Eliska Pospisilova, Vladimir Bobek, Peter Klezl, Renata Zobalova, Berwini Endaya, Jakub Rohlena, Lubos Petruzelka, Lukas Werner, Jiri Neuzil
Publikováno v: EClinicalMedicine, Vol 57, Iss , Pp 101873- (2023)
Summary: Background: Mitochondria present an emerging target for cancer treatment. We have investigated the effect of mitochondrially targeted tamoxifen (MitoTam), a first-in-class anti-cancer agent, in patients with solid metastatic tumours. Methods
Externí odkaz: https://doaj.org/article/91ab15755d5b4f4c9326f015bc30ba5c
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4
Akademický článek
Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice
Autor: Eliska Vacurova, Jaroslava Trnovska, Petr Svoboda, Vojtech Skop, Vendula Novosadova, David Pajuelo Reguera, Silvia Petrezselyová, Benoit Piavaux, Berwini Endaya, Frantisek Spoutil, Dagmar Zudova, Jan Stursa, Magdalena Melcova, Zuzana Bielcikova, Lukas Werner, Jan Prochazka, Radislav Sedlacek, Martina Huttl, Sona Stemberkova Hubackova, Martin Haluzik, Jiri Neuzil
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Senescent cells play a role in pathogenesis of diabetes, and senolytic agents can improve obesity- and diabetes-related pathologies. Here the authors report that mitochondrially targeted tamoxifen, a potential anti-cancer agent with senolytic activit
Externí odkaz: https://doaj.org/article/e1a97d3a7b444e588a78bce984149ca2
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6
Akademický článek
Extremely rapid isotropic irradiation of nanoparticles with ions generated in situ by a nuclear reaction
Autor: Jan Havlik, Vladimira Petrakova, Jan Kucka, Helena Raabova, Dalibor Panek, Vaclav Stepan, Zuzana Zlamalova Cilova, Philipp Reineck, Jan Stursa, Jan Kucera, Martin Hruby, Petr Cigler
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Mass production of nanoparticles containing well-controlled structural defects is a challenge. Here the authors demonstrate the feasibility of homogeneous ion irradiation generated in a nuclear reactor, for the preparation of fluorescent nanodiamonds
Externí odkaz: https://doaj.org/article/d24191b157dd408483a7995aee04b7c0
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