Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jan, Nouta"'
Autor:
Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer
Publikováno v:
Engineering, Vol 26, Iss , Pp 119-131 (2023)
Ketodeoxynononic acid (Kdn) is a rather uncommon class of sialic acid in mammals. However, associations have been found between elevated concentrations of free or conjugated Kdn in relation to human cancer progression. Hitherto, there has been a lack
Externí odkaz:
https://doaj.org/article/a218f8e8bafb472a93b2565b68e59d0e
Autor:
Julie Van Coillie, Tamas Pongracz, Tonći Šuštić, Wenjun Wang, Jan Nouta, Mathieu Le Gars, Sofie Keijzer, Federica Linty, Olvi Cristianawati, Jim B.D. Keijser, Remco Visser, Lonneke A. van Vught, Marleen A. Slim, Niels van Mourik, Merel J. Smit, Adam Sander, David E. Schmidt, Maurice Steenhuis, Theo Rispens, Morten A. Nielsen, Benjamin G. Mordmüller, Alexander P.J. Vlaar, C. Ellen van der Schoot, Ramon Roozendaal, Manfred Wuhrer, Gestur Vidarsson, Brent Appelman, Diederik van de Beek, Marije K. Bomers, Justin de Brabander, Matthijs C. Brouwer, David T.P. Buis, Nora Chekrouni, Marit J. van Gils, Menno D. de Jong, Ayesha H.A. Lavell, Sabine E. Olie, Edgar J.G. Peters, Tom D.Y. Reijnders, Michiel Schinkel, Alex R. Schuurman, Jonne J. Sikkens, Yvo M. Smulders, Joost W. Wiersinga, Antinori Spinello, Cinzia Bassoli, Giovanna Bestetti, Mario Corbellino, Alice Covizzi, Angelica Lupo, Laura Milazzo, Marco Schiuma, Alessandro Torre, Willem A. de Jongh, Ali Salanti, Thor G. Theander, Matthew B.B. McCall, Meral Esen
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107619- (2023)
Summary: IgG antibodies are important mediators of vaccine-induced immunity through complement- and Fc receptor-dependent effector functions. Both are influenced by the composition of the conserved N-linked glycan located in the IgG Fc domain. Here,
Externí odkaz:
https://doaj.org/article/1f6bd129608a46e19f6f87262c09f1b9
Autor:
Thijs L. J. van Osch, Juulke Steuten, Jan Nouta, Carolien A. M. Koeleman, Arthur E. H. Bentlage, Sebastiaan Heidt, Arend Mulder, Jan Voorberg, S. Marieke van Ham, Manfred Wuhrer, Anja ten Brinke, Gestur Vidarsson
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Immune-mediated platelet refractoriness (PR) remains a significant problem in the setting of platelet transfusion and is predominantly caused by the presence of alloantibodies directed against class I human leukocyte antigens (HLA). Opsonization of d
Externí odkaz:
https://doaj.org/article/754df94de50f494c88b096ba4996ae54
Autor:
Nienke Oskam, Timon Damelang, Marij Streutker, Pleuni Ooijevaar-de Heer, Jan Nouta, Carolien Koeleman, Julie Van Coillie, Manfred Wuhrer, Gestur Vidarsson, Theo Rispens
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Of the four human immunoglobulin G (IgG) subclasses, IgG4 is considered the least inflammatory, in part because it poorly activates the complement system. Regardless, in IgG4 related disease (IgG4-RD) and in autoimmune disorders with high levels of I
Externí odkaz:
https://doaj.org/article/fa7318757d8145ef9a4785fb09b3e46d
Autor:
Jana Sophia Buhre, Tamas Pongracz, Inga Künsting, Anne S. Lixenfeld, Wenjun Wang, Jan Nouta, Selina Lehrian, Franziska Schmelter, Hanna B. Lunding, Lara Dühring, Carsten Kern, Janina Petry, Emily L. Martin, Bandik Föh, Moritz Steinhaus, Vera von Kopylow, Christian Sina, Tobias Graf, Johann Rahmöller, Manfred Wuhrer, Marc Ehlers
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
BackgroundThe new types of mRNA-containing lipid nanoparticle vaccines BNT162b2 and mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS-CoV-2 and code for its spike (S) protein. Several studies have investigated short-term
Externí odkaz:
https://doaj.org/article/9780b485f10b4dde9b15bf92c47fa12a
Autor:
Julie Van Coillie, Tamas Pongracz, Johann Rahmöller, Hung-Jen Chen, Chiara Elisabeth Geyer, Lonneke A. van Vught, Jana Sophia Buhre, Tonći Šuštić, Thijs Luc Junior van Osch, Maurice Steenhuis, Willianne Hoepel, Wenjun Wang, Anne Sophie Lixenfeld, Jan Nouta, Sofie Keijzer, Federica Linty, Remco Visser, Mads Delbo Larsen, Emily Lara Martin, Inga Künsting, Selina Lehrian, Vera von Kopylow, Carsten Kern, Hanna Bele Lunding, Menno de Winther, Niels van Mourik, Theo Rispens, Tobias Graf, Marleen Adriana Slim, René Peter Minnaar, Marije Kristianne Bomers, Jonne Jochum Sikkens, Alexander P.J. Vlaar, C. Ellen van der Schoot, Jeroen den Dunnen, Manfred Wuhrer, Marc Ehlers, Gestur Vidarsson, Spinello Antinori, Cinzia Bassoli, Giovanna Bestetti, Mario Corbellino, Alice Covizzi, Angelica Lupo, Laura Milazzo, Marco Schiuma, Alessandro Torre, Brent Appelman, Diederik Beek van de, Marije K. Bomers, Justin Brabander de, Matthijs C. Brouwer, David T.P. Buis, Nora Chekrouni, Marit J. Gils van, Menno D. Jong de, Ayesha H.A. Lavell, Niels Mourik van, Sabine E. Olie, Edgar J.G. Peters, Tom D.Y. Reijnders, Michiel Schinkel, Alex R. Schuurman, Jonne J. Sikkens, Marleen A. Slim, Yvo M. Smulders, Lonneke A. Vught van, Joost W. Wiersinga
Publikováno v:
EBioMedicine, Vol 87, Iss , Pp 104408- (2023)
Summary: Background: Afucosylated IgG1 responses have only been found against membrane-embedded epitopes, including anti-S in SARS-CoV-2 infections. These responses, intrinsically protective through enhanced FcγRIIIa binding, can also trigger exacer
Externí odkaz:
https://doaj.org/article/bd40a551975d4a2c9340f940154e729f
Autor:
Mads Delbo Larsen, Mary Lopez-Perez, Emmanuel Kakra Dickson, Paulina Ampomah, Nicaise Tuikue Ndam, Jan Nouta, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Benjamin Mordmüller, Ali Salanti, Morten Agertoug Nielsen, Achille Massougbodji, C. Ellen van der Schoot, Michael F. Ofori, Manfred Wuhrer, Lars Hviid, Gestur Vidarsson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Here, Larsen et al. describe differences in Fc fucosylation of P. falciparum PfEMP1-specific IgG produced in response to natural infection versus VAR2CSA-type subunit vaccination, which leads to differences in the ability to induce FcγRIIIa-dependen
Externí odkaz:
https://doaj.org/article/a9888fc047054d7cb375efcf290854a4
Autor:
Sterre L. Siekman, Tamas Pongracz, Wenjun Wang, Jan Nouta, Peter G. Kremsner, Pedro Vieira da Silva-Neto, Meral Esen, Andrea Kreidenweiss, Jana Held, Átila Alexandre Trapé, Rolf Fendel, Isabel Kinney Ferreira de Miranda Santos, Manfred Wuhrer, ImmunoCovid Consortium, Alessandro P. de Amorim, Jamille G M. Argolo, Rita de C.C. Barbieri, Marcelo Dias-Baruffi, Victor A F. Bastos, Vânia L D. Bonat, Cristina Ribeiro de Barros Cardoso, Ingryd Carmona-Garcia, Jonatan C S de Carvalho, Leticia F. Constant, Augusto M. Degiovani, Cassia F.S.L. Dias, Lúcia H. Faccioli, Marley R. Feitosa, Omar Feres, Ana Paula Morais Fernandes, Talita M. Fernandes, Thais F C. Fraga-Silva, Carlos Fuzo, Isabelle C. Guarneri, Cristiane M. Milanezi, Caroline T. Garbato, Gilberto Gambero Gaspar, Ângelo A.F. Júnior, Sandra R. Maruyama, Debora C. Nepomuceno, Nicola T. Neto, Camilla Narjara Simão Oliveira, Fátima M. Ostini, Rogerio S. Parra, Malena M. Pérez, Vinı́cius E. Pimentel, Giovanna da S. Porcel, José J R da Rocha, Lilian C. Rodrigues, Elisa M S. Russo, Dayane P. da Silva, Rafael C. da Silva, Carlos Arterio Sorgi, Camila O S. Souza, Diana M. Toro, Angelina L. Viana, Fernando Crivelenti Vilar, Ana C. Xavier, Kamila Zaparoli
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunoglobulin G (IgG) antibodies play an important role in the immune response against viruses such as SARS-CoV-2. As the effector functions of IgG are modulated by N-glycosylation of the Fc region, the structure and possible function of the IgG N-g
Externí odkaz:
https://doaj.org/article/6158a9fbd2d94ee5a9418faadd9e7247
Autor:
Tonći Šuštić, Julie Van Coillie, Mads Delbo Larsen, Ninotska I.L. Derksen, Zoltan Szittner, Jan Nouta, Wenjun Wang, Timon Damelang, Ianthe Rebergen, Federica Linty, Remco Visser, Juk Yee Mok, Dionne M. Geerdes, Wim J.E. van Esch, Steven W. de Taeye, Marit J. van Gils, Leo van de Watering, C. Ellen van der Schoot, Manfred Wuhrer, Theo Rispens, Gestur Vidarsson
Publikováno v:
EBioMedicine, Vol 81, Iss , Pp 104109- (2022)
Summary: Background: Immunoglobulin G (IgG) antibodies serve a crucial immuno-protective function mediated by IgG Fc receptors (FcγR). Absence of fucose on the highly conserved N-linked glycan in the IgG Fc domain strongly enhances IgG binding and a
Externí odkaz:
https://doaj.org/article/da752767a6eb419586c7246f663844e9
Autor:
Tamas Pongracz, Jan Nouta, Wenjun Wang, Krista E. van Meijgaarden, Federica Linty, Gestur Vidarsson, Simone A. Joosten, Tom H.M. Ottenhoff, Cornelis H. Hokke, Jutte J.C. de Vries, Sesmu M. Arbous, Anna H.E. Roukens, Manfred Wuhrer
Publikováno v:
EBioMedicine, Vol 78, Iss , Pp 103957- (2022)
Summary: Background: Immunoglobulin G1 (IgG1) effector functions are impacted by the structure of fragment crystallizable (Fc) tail-linked N-glycans. Low fucosylation levels on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) pr
Externí odkaz:
https://doaj.org/article/d1d4814281ce4ec7ba68913c86f07a78