Zobrazeno 1 - 10
of 351
pro vyhledávání: '"Jan, Nedergaard"'
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 271, Iss , Pp 115955- (2024)
Perfluorooctanoic acid (PFOA) is a synthetic organofluoride surfactant associated with several toxic effects in humans and animals. Particularly, it has been observed that PFOA treatment of mice results in weight loss associated with recruited brown
Externí odkaz:
https://doaj.org/article/31b1391683824cdbb618a80d352e5e7b
Autor:
Gabriella von Essen, Erik Lindsund, Elaina M. Maldonado, Petr Zouhar, Barbara Cannon, Jan Nedergaard
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101782- (2023)
Objective: The possibility to counteract the development of obesity in humans by recruiting brown or brite/beige adipose tissue (and thus UCP1) has attracted much attention. Here we examine if a diet that can activate diet-induced thermogenesis can e
Externí odkaz:
https://doaj.org/article/3f0fda2ccbd2477c8f0df7d18f5fb857
Autor:
Petr Zouhar, Petra Janovska, Sara Stanic, Kristina Bardova, Jiri Funda, Blanka Haberlova, Birgitte Andersen, Martin Rossmeisl, Barbara Cannon, Jan Kopecky, Jan Nedergaard
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101324- (2021)
Objective: Administration of FGF21 to mice reduces body weight and increases body temperature. The increase in body temperature is generally interpreted as hyperthermia, i.e. a condition secondary to the increase in energy expenditure (heat productio
Externí odkaz:
https://doaj.org/article/a100dc94416a442f99f55a7a76712e79
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
The potential ability of nutritional compounds to induce or enhance the browning of adipocytes has attracted large interest as a workable means of combatting the obesity epidemic. Green tea compounds are discussed as such inducers of an enhanced ther
Externí odkaz:
https://doaj.org/article/642cf992426a4ac493985c524ba40cc7
Autor:
Luís Felipe Galvão Valdivia, Érique Castro, Rosangela Aparecida dos Santos Eichler, Mayara Franzoi Moreno, Érica de Sousa, Giovanna Freitas Rodrigues Jardim, Álbert Souza Peixoto, Maria Nathália Moraes, Ana Maria de Lauro Castrucci, Jan Nedergaard, Natasa Petrovic, William T. Festuccia, Patrícia Reckziegel
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 324:E358-E373
Cold acclimation and PPARγ agonism combined markedly increase brown and white adipose tissue total UCP1 content and mRNA levels of thermogenesis-related proteins. Higher UCP1 protein levels did not result in higher energy expenditure. The high therm
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 20-34 (2019)
Objective: Hyperthyroidism is associated with increased metabolism (“thyroid thermogenesis”) and elevated body temperature, often referred to as hyperthermia. Uncoupling protein-1 (UCP1) is the protein responsible for nonshivering thermogenesis i
Externí odkaz:
https://doaj.org/article/8747d8ce52794543aa1aefed69ecee64
Publikováno v:
Physiological and Biochemical Zoology. 96:30-39
Publikováno v:
Molecular Metabolism, Vol 7, Iss , Pp 161-170 (2018)
Objectives: The laboratory mouse is presently the most common model for examining mechanisms of human physiology and disease. Housing temperatures can have a large impact on the outcome of such experiments and on their translatability to the human si
Externí odkaz:
https://doaj.org/article/90dd6ff84ade4321ac01c2cee5452da5
Autor:
Jessica M. Olsen, Robert I. Csikasz, Nodi Dehvari, Li Lu, Anna Sandström, Anette I. Öberg, Jan Nedergaard, Sharon Stone-Elander, Tore Bengtsson
Publikováno v:
Molecular Metabolism, Vol 6, Iss 6, Pp 611-619 (2017)
Objective: Today, the presence and activity of brown adipose tissue (BAT) in adult humans is generally equated with the induced accumulation of [2-18F]2-fluoro-2-deoxy-d-glucose ([18F]FDG) in adipose tissues, as investigated by positron emission tomo
Externí odkaz:
https://doaj.org/article/a8709001969046e0a106db48671aca25
Autor:
Ineke H.N. Luijten, Katie Brooks, Nathalie Boulet, Irina G. Shabalina, Ankita Jaiprakash, Bo Carlsson, Alexander W. Fischer, Barbara Cannon, Jan Nedergaard
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1686-1698.e5 (2019)
Summary: An excess of glucocorticoids leads to the development of obesity in both mice and humans, but the mechanism for this is unknown. Here, we determine the extent to which decreased BAT thermogenic capacity (as a result of glucocorticoid treatme
Externí odkaz:
https://doaj.org/article/3afa71a84a774e268ddc95c8709394e6