Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Jan, Mueller"'
Autor:
Anastasia Papaporfyriou, Konstantinos Bartziokas, Ioulianos Apessos, Jan Mueller, Vasileios Leivaditis, Efstratios Koletsis, Konstantinos Grapatsas
Publikováno v:
Current Oncology, Vol 31, Iss 10, Pp 6289-6299 (2024)
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide. Immunotherapy has emerged as a promising treatment option due to its favorable toxicity profile. However, selecting the most appropriate immunotherapeut
Externí odkaz:
https://doaj.org/article/ef2c3b34cb5445f59b491e2276a2607f
Autor:
Jan Mueller, Roman R Schimmer, Christian Koch, Florin Schneiter, Jonas Fullin, Veronika Lysenko, Christian Pellegrino, Nancy Klemm, Norman Russkamp, Renier Myburgh, Laura Volta, Alexandre PA Theocharides, Kari J Kurppa, Benjamin L Ebert, Timm Schroeder, Markus G Manz, Steffen Boettcher
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 445-474 (2024)
Abstract TP53-mutant acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are characterized by chemotherapy resistance and represent an unmet clinical need. Chimeric antigen receptor (CAR) T-cells might be a promising therapeutic option f
Externí odkaz:
https://doaj.org/article/3995291a6c424aeaadea031a81b64f56
Autor:
Mirko Sonntag, Vanessa K. Elgeti, Yevhen Vainshtein, Lucca Jenner, Jan Mueller, Thorsten Brenner, Sebastian O. Decker, Kai Sohn
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5463 (2024)
Sepsis is a life-threatening syndrome triggered by infection and accompanied by high mortality, with antimicrobial resistances (AMRs) further escalating clinical challenges. The rapid and reliable detection of causative pathogens and AMRs are key fac
Externí odkaz:
https://doaj.org/article/29e75257f1d64980a5435e543dd853fd
Autor:
Julia Damiano-Guercio, Laëtitia Kurzawa, Jan Mueller, Georgi Dimchev, Matthias Schaks, Maria Nemethova, Thomas Pokrant, Stefan Brühmann, Joern Linkner, Laurent Blanchoin, Michael Sixt, Klemens Rottner, Jan Faix
Publikováno v:
eLife, Vol 9 (2020)
Cell migration entails networks and bundles of actin filaments termed lamellipodia and microspikes or filopodia, respectively, as well as focal adhesions, all of which recruit Ena/VASP family members hitherto thought to antagonize efficient cell moti
Externí odkaz:
https://doaj.org/article/5218dcb94c6e4b91a3ad1f89f9bb6945
Autor:
Philip Konietzke, Jan Mueller, Felix Wuennemann, Willi L Wagner, Jens-Peter Schenk, Abdulsattar Alrajab, Hans-Ulrich Kauczor, Mirjam Stahl, Marcus A Mall, Mark O Wielpütz, Olaf Sommerburg
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230252 (2020)
INTRODUCTION:In children with pneumonia, chest x-ray (CXR) is typically the first imaging modality used for diagnostic work-up. Repeated CXR or computed tomography (CT) are often necessary if complications such as abscesses or empyema arise, thus inc
Externí odkaz:
https://doaj.org/article/d3f960fa824744328df79df46f0f6bfc
Autor:
Frieda Kage, Moritz Winterhoff, Vanessa Dimchev, Jan Mueller, Tobias Thalheim, Anika Freise, Stefan Brühmann, Jana Kollasser, Jennifer Block, Georgi Dimchev, Matthias Geyer, Hans-Joachim Schnittler, Cord Brakebusch, Theresia E. B. Stradal, Marie-France Carlier, Michael Sixt, Josef Käs, Jan Faix, Klemens Rottner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Actin polymerization in lamellipodia of cells is regulated by the Arp2/3 complex and FMNL family formins. Here the authors show that both FMNL2 and FMNL3 contribute to lamellipodium protrusion and structure, and abolishing FMNL2/3 reduces protrusion
Externí odkaz:
https://doaj.org/article/68b36f54d59e40399f6718c304c31181
Autor:
Hans-Georg Matuttis, Jan Mueller
Publikováno v:
Journal of Applied Mathematics and Physics. :1257-1270
In this research, we have improved a relaxation method for triangular meshes intended for finite element fluid simulations which contain discrete element particles. The triangle edges are treated as springs which relax their lengths towards a “bett
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d71848b0ba5945677e4b8a481a06d15f
https://doi.org/10.4236/jamp.2021.96086
https://doi.org/10.4236/jamp.2021.96086
Autor:
Anna S. Pakhomova, Georg Spiekermann, Nicole Biedermann, Karen Appel, Wolfgang Morgenroth, Ilias Efthimiopoulos, Max Wilke, Konstantin Glazyrin, Jan Mueller, Elena Bykova
Publikováno v:
European Journal of Mineralogy. 32:575-586
The high-pressure phase transition of strontianite ( SrCO3 ) was investigated at ambient temperature by means of powder and single-crystal X-ray diffraction. The samples were compressed in a diamond anvil cell to a maximum pressure of 49 GPa. Structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71018baac432ccb59077adc73a5dc2fa
https://doi.org/10.5194/ejm-32-575-2020
https://doi.org/10.5194/ejm-32-575-2020
Publikováno v:
Journal of Applied Mathematics and Physics. :1779-1798
In this paper, we propose a combination of discrete elements for the soil and finite elements for the fluid flow field inside the pore space to simulate the triggering of landslides. We give the details for the implementation of third order finite el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1543d0c8c296864e4019ebb840bded65
https://doi.org/10.4236/jamp.2020.89134
https://doi.org/10.4236/jamp.2020.89134
Autor:
Lorena Decker, Patricia Fraungruber, Jan Mueller, Fabian Trillsch, Lewis Francis, Sven Mahner, Philipp Rathert, R. Steven Conlan, Ann-Katrin Loeffler, Sabine Pinter, Stephan A. Eisler, Tabea L. Bauer, Udo Jeschke, Johannes Zuber, Stefan Kommoss, Till Kaltofen, Annette Staebler, Katrin Collmar
Publikováno v:
Cancers
Volume 13
Issue 15
Cancers, Vol 13, Iss 3801, p 3801 (2021)
Volume 13
Issue 15
Cancers, Vol 13, Iss 3801, p 3801 (2021)
Simple Summary Most epithelial ovarian cancer (EOC) patients, although initially responsive to standard treatment with platinum-based chemotherapy, develop platinum resistance over the clinical course and succumb due to drug-resistant metastases. It
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d982252a2d24663935eba7e03ce1164
http://europepmc.org/articles/PMC8345099
http://europepmc.org/articles/PMC8345099