Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jan, Molenaar"'
Autor:
Francisco Avila Cobos, Mohammad Javad Najaf Panah, Jessica Epps, Xiaochen Long, Tsz-Kwong Man, Hua-Sheng Chiu, Elad Chomsky, Evgeny Kiner, Michael J. Krueger, Diego di Bernardo, Luis Voloch, Jan Molenaar, Sander R. van Hooff, Frank Westermann, Selina Jansky, Michele L. Redell, Pieter Mestdagh, Pavel Sumazin
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract Background RNA profiling technologies at single-cell resolutions, including single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, scnRNA-seq for short), can help characterize the composition of tissues and reveal cells that
Externí odkaz:
https://doaj.org/article/d4626884e3864b748b5d6fb020d26428
Autor:
Lu Lu, Reina S. Sikkema, Francisca C. Velkers, David F. Nieuwenhuijse, Egil A. J. Fischer, Paola A. Meijer, Noortje Bouwmeester-Vincken, Ariene Rietveld, Marjolijn C. A. Wegdam-Blans, Paulien Tolsma, Marco Koppelman, Lidwien A. M. Smit, Renate W. Hakze-van der Honing, Wim H. M. van der Poel, Arco N. van der Spek, Marcel A. H. Spierenburg, Robert Jan Molenaar, Jan de Rond, Marieke Augustijn, Mark Woolhouse, J. Arjan Stegeman, Samantha Lycett, Bas B. Oude Munnink, Marion P. G. Koopmans
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
SARS-CoV-2 was detected in mink farms in the Netherlands in the first wave of the pandemic with evidence of human-to-mink and mink-to-human transmission. Here, the authors investigate this outbreak using phylodynamic analysis and show that personnel
Externí odkaz:
https://doaj.org/article/6d32ab4b74c24337a5d889e4f5b33778
Autor:
Gabriele Manzella, Leonie D. Schreck, Willemijn B. Breunis, Jan Molenaar, Hans Merks, Frederic G. Barr, Wenyue Sun, Michaela Römmele, Luduo Zhang, Joelle Tchinda, Quy A. Ngo, Peter Bode, Olivier Delattre, Didier Surdez, Bharat Rekhi, Felix K. Niggli, Beat W. Schäfer, Marco Wachtel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Patient-specific precision medicine approaches are important for future cancer therapies. Here, the authors show that functional drug profiling with Rhabdomyosarcoma cells isolated from PDX and primary patient tumors uncovers patient-specific vulnera
Externí odkaz:
https://doaj.org/article/e1a776112ff34407a13275f886ecd3a9
Autor:
Wendy J. Wolters, Myrna M. T. de Rooij, Robert Jan Molenaar, Jan de Rond, J. C. M. Vernooij, Paola A. Meijer, Bas B. Oude Munnink, Reina S. Sikkema, Arco N. van der Spek, Marcel A. H. Spierenburg, Renate W. Hakze-van der Honing, Wim H. M. van der Poel, Marion P. G. Koopmans, J. Arjan Stegeman, Lidwien A. M. Smit, Marieke Augustijn-Schretlen, Francisca C. Velkers
Publikováno v:
Viruses, Vol 14, Iss 8, p 1754 (2022)
SARS-CoV-2 outbreaks on 69 Dutch mink farms in 2020 were studied to identify risk factors for virus introduction and transmission and to improve surveillance and containment measures. Clinical signs, laboratory test results, and epidemiological aspec
Externí odkaz:
https://doaj.org/article/8887a56e150246b7821702bcab76ef20
Autor:
Francisco Avila Cobos, Mohammad Javad Najaf Panah, Jessica Epps, Xiaochen Long, Tsz-Kwong Man, Hua-Sheng Chiu, Elad Chomsky, Evgeny Kiner, Michael J Krueger, Diego di Bernardo, Luis Voloch, Jan Molenaar, Sander R. van Hooff, Frank Westermann, Selina Jansky, Michele L. Redell, Pieter Mestdagh, Pavel Sumazin
RNA profiling technologies at single-cell resolutions, including single-cell and single-nuclei RNA sequencing (scRNA-Seq and snRNA-Seq, scnRNA-Seq for short), can help characterize the composition of tissues and reveal cells that influence key functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82d6e2658d4d1bada548c73ee791ec99
https://doi.org/10.1101/2022.12.13.520241
https://doi.org/10.1101/2022.12.13.520241
Autor:
Muhammad Rishfi, Simon Krols, Fien Martens, Sarah-Lee Bekaert, Ellen Sanders, Aline Eggermont, Fanny De Vloed, Joshua Robert Goulding, Martijn Risseeuw, Jan Molenaar, Bram De Wilde, Serge Van Calenbergh, Kaat Durinck
Publikováno v:
European Journal of Medicinal Chemistry. 247:115033
Aurora kinase A (AURKA) is a well-established target in neuroblastoma (NB) due to its catalytic functions during mitosis and due to stabilisation of the key oncoprotein MYCN. We report a small structure-activity relationship (SAR) study of MK-5108-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aedaeb78a0262cf59205bdd691faefe
https://doi.org/10.1016/j.ejmech.2022.115033
https://doi.org/10.1016/j.ejmech.2022.115033
Autor:
Noortje Bouwmeester-Vincken, Francisca C. Velkers, Mark E. J. Woolhouse, M. C. A. Wegdam-Blans, Arjan Stegeman, M. Augustijn, R. Hakze-van der Honing, A. N. van der Spek, Samantha Lycett, B.B. Oude Munnink, Reina S. Sikkema, M. Koppelman, Marcel A.H. Spierenburg, L.A.M. Smit, Lu Lu, W.H.M. van der Poel, J. de Rond, Paola A. Meijer, David F. Nieuwenhuijse, Egil A.J. Fischer, Robert-Jan Molenaar, Ariene Rietveld, Paulien Tolsma, M. P. G. Koppelman
In the first wave of the COVID-19 pandemic (April 2020), SARS-CoV-2 was detected in farmed minks and genomic sequencing was performed on mink farms and farm personnel. Here, we describe the outbreak and use sequence data with Bayesian phylodynamic me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8606fcf10ae75caa46a75793533460b2
https://doi.org/10.1101/2021.07.13.452160
https://doi.org/10.1101/2021.07.13.452160
Autor:
Corine H. GeurtsvanKessel, Emmanuelle Munger, Richard Molenkamp, Marion Koopmans, Reina S. Sikkema, Arjan Stegeman, Renate Hakze-van der Honing, Ruth Bouwstra, Noortje Bouwmeester-Vincken, Francisca C. Velkers, Bas B. Oude Munnink, Marjolein C.A. Wegdam-Blans, Ariene Rietveld, Arco N. van der Spek, Lidwien A.M. Smit, Robert Jan Molenaar, Wim H.M. van der Poel, Miranda Brouwer, Frank Harders, Paulin Tolsma, David F. Nieuwenhuijse, Annemiek A. van der Eijk
The zoonotic origin of the SARS-CoV-2 pandemic is still unknown. Animal experiments have shown that non-human primates, cats, ferrets, hamsters, rabbits and bats can be infected by SARS-CoV-2. In addition, SARS-CoV-2 RNA has been detected in felids,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a643a87be1316e145a85e2b34225cc4
https://doi.org/10.1101/2020.09.01.277152
https://doi.org/10.1101/2020.09.01.277152
Autor:
Robert-Jan Molenaar, Eefke Weesendorp, Myrna M.T. de Rooij, Nora M. Gerhards, Marc Y. Engelsma, Christianne Bruschke, Paulien Tolsma, Frank Harders, Nadia Oreshkova, Wim H.M. van der Poel, Sandra Vreman, Bas B. Oude Munnink, Marion Koopmans, Lidwien A.M. Smit, Reina S. Sikkema, Jan Arend Stegeman, Mirriam G.J. Tacken, Renate W. Hakze-vd Honing, Ruth Bouwstra
In April 2020, respiratory disease and increased mortality were observed in farmed mink on two farms in the Netherlands. In both farms, at least one worker had been found positive for SARS-CoV-2. Necropsies of the mink revealed interstitial pneumonia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::402bc803455f7e50a4d4d4620ab119cc
https://doi.org/10.1101/2020.05.18.101493
https://doi.org/10.1101/2020.05.18.101493
Publikováno v:
Avian Pathology
This paper describes the characterization of a new infectious bronchitis virus (IBV) strain D181, that rapidly evolved from a low-level incidental finding in 2017 to become the second most isolated IBV strain in Dutch layers and breeders in 2018, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee0a5e43708005c7feed32753dc3ee2
https://pubmed.ncbi.nlm.nih.gov/31951468
https://pubmed.ncbi.nlm.nih.gov/31951468