A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

Autor: Stefan Reich, Chi D. L. Nguyen, Canan Has, Sascha Steltgens, Himanshu Soni, Cristina Coman, Moritz Freyberg, Anna Bichler, Nicole Seifert, Dominik Conrad, Christiane B. Knobbe-Thomsen, Björn Tews, Grischa Toedt, Robert Ahrends, Jan Medenbach

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

The unfolded protein response (UPR) is a stress response pathway implicated in numerous diseases and chemotherapy resistance. Here, the authors define the UPR regulon with a multi-omics strategy, uncovering changes to mitochondrial one-carbon metabol

Externí odkaz: https://doaj.org/article/79d8f5e4871145f68820d3fe6d215985

Simple Targeted Assays for Metabolic Pathways and Signaling: A Powerful Tool for Targeted Proteomics

Autor: Bo Burla, Douglas G. Mashek, Dominik Kopczynski, Jan Medenbach, Michael R. Kreutz, René P. Zahedi, Federico Torta, Hans Frieder Schött, Albert Sickmann, Robert Ahrends, Cristina Coman, Andreas Hentschel, Nils Helge Schebb, Thorsten Hornemann, Kristina Lorenz, Nicole M. Hartung, Olga Shevchuk, Christer S. Ejsing

Publikováno v: Kopczynski, D, Hentschel, A, Coman, C, Schebb, N H, Hornemann, T, Mashek, D G, Hartung, N M, Shevchuk, O, Schött, H F, Lorenz, K, Torta, F, Burla, B, Zahedi, R P, Sickmann, A, Kreutz, M R, Ejsing, C S, Medenbach, J & Ahrends, R 2020, ' Simple Targeted Assays for Metabolic Pathways and Signaling : A Powerful Tool for Targeted Proteomics ', Analytical chemistry, vol. 92, no. 20, pp. 13672-13676 . https://doi.org/10.1021/acs.analchem.0c02793
Analytical Chemistry
Analytical chemistry 92(20), 13672-13676 (2020). doi:10.1021/acs.analchem.0c02793

We introduce STAMPS, a pathway-centric web service for the development of targeted proteomics assays. STAMPS guides the user by providing several intuitive interfaces for a rapid and simplified method design. Applying our curated framework to signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb33b87c8295f6eacd4b3e6aa0d2031
https://doi.org/10.1021/acs.analchem.0c02793

Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26

Autor: Anna Salerno-Kochan, Andreas Horn, Pritha Ghosh, Chandran Nithin, Anna Kościelniak, Andreas Meindl, Daniela Strauss, Rościsław Krutyhołowa, Oliver Rossbach, Janusz M Bujnicki, Monika Gaik, Jan Medenbach, Sebastian Glatt

The TRIM-NHL protein Meiotic P26 (Mei-P26) acts as a regulator of cell fate in Drosophila. Its activity is critical for ovarian germline stem cell maintenance, differentiation of oocytes, and spermatogenesis. Mei-P26 functions as a post-transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34791bf60636beccc0571d2a7202c512

Stress macht Zellen resistent gegen Folsäure-basierte Chemotherapeutika

Autor: Robert Ahrends, Jan Medenbach

Publikováno v: BIOspektrum. 26:609-611

The unfolded protein response (UPR), a cellular stress response pathway, is broadly implicated in disease and resistance to therapy. The molecular mechanisms that drive stress-mediated chemoresistance are, however, only poorly understood. We have emp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7585e074ee40caf2b36aab14a270329
https://doi.org/10.1007/s12268-020-1457-4

Promiscuity in post-transcriptional control of gene expression:Drosophilasex-lethal and its regulatory partnerships

Autor: Jan Medenbach, Rebecca Moschall, Monika Gaik

Publikováno v: Febs Letters

The Drosophila RNA‐binding protein Sex‐lethal (Sxl) is a potent post‐transcriptional regulator of gene expression that controls female development. It regulates the expression of key factors involved in sex‐specific differences in morphology,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b9801c610c18ec865941c58bd5bff9
https://doi.org/10.1002/1873-3468.12652