Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Jan, Marik"'
Autor:
Johannes Riegler, Herman Gill, Annie Ogasawara, Maj Hedehus, Vincent Javinal, Jason Oeh, Gregory Z. Ferl, Jan Marik, Simon Williams, Deepak Sampath, Jill Schartner, Richard A.D. Carano
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 10, Pp 1036-1050 (2019)
Cancer immunotherapies have demonstrated durable responses in a range of different cancers. However, only a subset of patients responds to these therapies. We set out to test if non-invasive imaging of tumor perfusion and vascular inflammation may be
Externí odkaz:
https://doaj.org/article/741a375fc66146b38b3c4feb55c71ce8
Autor:
Shravan Kumar Sriraman, Christopher W. Davies, Herman Gill, James R. Kiefer, Jianping Yin, Annie Ogasawara, Alejandra Urrutia, Vincent Javinal, Zhonghua Lin, Dhaya Seshasayee, Ryan Abraham, Phil Haas, Christopher Koth, Jan Marik, James T. Koerber, Simon Peter Williams
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 50:679-691
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f089c094378cad1bc4da07510270b743
https://doi.org/10.1007/s00259-022-05998-0
https://doi.org/10.1007/s00259-022-05998-0
Autor:
Richard Zang, Aline Barth, Harvey Wong, Jan Marik, Jie Shen, Julie Lade, Kerri Grove, Matthew R. Durk, Neil Parrott, Patrick J. Rudewicz, Sylvia Zhao, Tao Wang, Zhengyin Yan, Donglu Zhang
Publikováno v:
Journal of Medicinal Chemistry. 65:8713-8734
The "free drug hypothesis" assumes that, in the absence of transporters, the steady state free plasma concentrations equal to that at the site of action that elicit pharmacologic effects. While it is important to utilize the free drug hypothesis, exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed020e19b1e50a9215ac6334a3b2b529
https://doi.org/10.1021/acs.jmedchem.2c00502
https://doi.org/10.1021/acs.jmedchem.2c00502
Autor:
Simon-Peter Williams, Suzie J. Scales, Jan Marik, Ron Firestein, Dongwei Li, Nidhi Gupta, Jeff N. Tinianow, Alexander N. Vanderbilt, Glenn Pacheco, Annie Ogasawara, Anton G.T. Terwisscha van Scheltinga
Supplementary Figure 1: Serum levels of AMA-MMAE in mice. Supplementary Figure 2: Correlation plot of tumor growth inhibition versus specific tumor uptake. Supplementary Table 1: Overview results. Supplementary Table 2: Tumor growth inhibition study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468bd46c914b424ebc2d10e18892c40f
https://doi.org/10.1158/1535-7163.22508646
https://doi.org/10.1158/1535-7163.22508646
Autor:
Neelie Zacharias, Vladimir N. Podust, Kimberly K. Kajihara, Douglas Leipold, Geoffrey Del Rosario, Desiree Thayer, Emily Dong, Maciej Paluch, David Fischer, Kai Zheng, Corinna Lei, Jintang He, Carl Ng, Dian Su, Luna Liu, Shabkhaiz Masih, William Sawyer, Jeff Tinianow, Jan Marik, Victor Yip, Guangmin Li, Josefa Chuh, J. Hiroshi Morisaki, Summer Park, Bing Zheng, Hilda Hernandez-Barry, Kelly M. Loyet, Min Xu, Katherine R. Kozak, Gail Lewis Phillips, Ben-Quan Shen, Cong Wu, Keyang Xu, Shang-Fan Yu, Amrita Kamath, Rebecca K. Rowntree, Dorothea Reilly, Thomas Pillow, Andrew Polson, Volker Schellenberger, Wouter L. W. Hazenbos, Jack Sadowsky
Publikováno v:
Chemical Science. 13:3147-3160
The antibody-drug conjugate (ADC) is a well-validated modality for the cell-specific delivery of small molecules with impact expanding rapidly beyond their originally-intended purpose of treating cancer. However, antibody-mediated delivery (AMD) rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bce602efd8f14a1021c22dad6d1512
https://doi.org/10.1039/d1sc05243h
https://doi.org/10.1039/d1sc05243h
Supplementary Figure 1 Legend from Use of a Peptide Derived from Foot-and-Mouth Disease Virus for the Noninvasive Imaging of Human Cancer: Generation and Evaluation of 4-[18F]Fluorobenzoyl A20FMDV2 for In vivo Imaging of Integrin αvβ6 Expression wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f19b09d17534bdc66b1cf7bec12c422
https://doi.org/10.1158/0008-5472.22368425.v1
https://doi.org/10.1158/0008-5472.22368425.v1
Expression of the epithelial-specific integrin αvβ6 is low or undetectable in most adult tissues but may be increased during wound healing and inflammation and is up-regulated dramatically by many different carcinomas, making αvβ6 a promising tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c0cbdfe594cd65b7cddac09d2d443a
https://doi.org/10.1158/0008-5472.c.6495953
https://doi.org/10.1158/0008-5472.c.6495953
Supplementary Figure 1 from Use of a Peptide Derived from Foot-and-Mouth Disease Virus for the Noninvasive Imaging of Human Cancer: Generation and Evaluation of 4-[18F]Fluorobenzoyl A20FMDV2 for In vivo Imaging of Integrin αvβ6 Expression with Posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777d88abc9aa78854b4f003a5b32c232
https://doi.org/10.1158/0008-5472.22368422.v1
https://doi.org/10.1158/0008-5472.22368422.v1
Autor:
Julie L. Sutcliffe, Cathy E. Stanecki, John F. Marshall, Jan Marik, M. Karen Gagnon, Richard J. Bold, Craig K. Abbey, Sven H. Hausner
Supplementary Methods, Table, Figures 1-4 from Targeted In vivo Imaging of Integrin αvβ6 with an Improved Radiotracer and Its Relevance in a Pancreatic Tumor Model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae0cc75aeedd3ed7d3d654a24c34a5e
https://doi.org/10.1158/0008-5472.22378548
https://doi.org/10.1158/0008-5472.22378548
Autor:
Annie, Ogasawara, James R, Kiefer, Herman, Gill, Eugene, Chiang, Shravan, Sriraman, Gregory Z, Ferl, James, Ziai, Sandra Sanabria, Bohorquez, Sebastian, Guelman, Xiangdan, Wang, Jihong, Yang, Minh Michael, Phan, Van, Nguyen, Shan, Chung, Christine, Yu, Jeff, Tinianow, Stijn Jan Hein, Waaijer, Alex, De Crespigny, Jan, Marik, C Andrew, Boswell, Tanja, Zabka, Karin, Staflin, Simon-Peter, Williams
Publikováno v:
European journal of nuclear medicine and molecular imaging. 50(2)
ZED8 is a novel monovalent antibody labeled with zirconium-89 for the molecular imaging of CD8. This work describes nonclinical studies performed in part to provide rationale for and to inform expectations in the early clinical development of ZED8, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31e464b63e7f56aaa5305457496e7b95
https://pubmed.ncbi.nlm.nih.gov/36427067
https://pubmed.ncbi.nlm.nih.gov/36427067