Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jan, Mani"'
Autor:
Caroline E. Dewar, Silke Oeljeklaus, Jan Mani, Wignand W. D. Mühlhäuser, Corinne von Känel, Johannes Zimmermann, Torsten Ochsenreiter, Bettina Warscheid, André Schneider
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Mitochondria import most of their proteins posttranslationally. Here, Dewar et al. characterize the mitochondrial quality control mechanism of Trypanosoma brucei. Through proteomics and functional studies, they show that only ablation of ATOM69, one
Externí odkaz:
https://doaj.org/article/3b2387b2f9184a889fa3ce9cdccdc488
Autor:
Christian D. Peikert, Jan Mani, Marcel Morgenstern, Sandro Käser, Bettina Knapp, Christoph Wenger, Anke Harsman, Silke Oeljeklaus, André Schneider, Bettina Warscheid
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Knowing the specific protein content of individual organelles is necessary for an integrated understanding of cellular physiology. Here the authors describe a mass spectrometry-based approach to identify the substrates of distinct protein import path
Externí odkaz:
https://doaj.org/article/bf7073abf7dd409ea6d6cecc74034615
Autor:
Jan Mani, Caroline E. Dewar, Bettina Warscheid, Silke Oeljeklaus, Wignand W. D. Mühlhäuser, André Schneider
Mitochondrial protein import in the parasitic protozoan Trypanosoma brucei is mediated by the atypical outer membrane translocase, ATOM. It consists of seven subunits including ATOM69, the import receptor for hydrophobic proteins. Ablation of ATOM69,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f2b57cadfc9680934aecbf3f0980957
https://doi.org/10.1101/2021.08.13.456187
https://doi.org/10.1101/2021.08.13.456187
Autor:
Jan Mani, Andreas Güttinger, Bernd Schimanski, Manfred Heller, Alvaro Acosta-Serrano, Pascale Pescher, Gerald Späth, Isabel Roditi
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22463 (2011)
Trypanosoma brucei and related pathogens transcribe most genes as polycistronic arrays that are subsequently processed into monocistronic mRNAs. Expression is frequently regulated post-transcriptionally by cis-acting elements in the untranslated regi
Externí odkaz:
https://doaj.org/article/7f852993552e4f528f238d121bc6dcfb
Autor:
Daniel Nilsson, Kapila Gunasekera, Jan Mani, Magne Osteras, Laurent Farinelli, Loic Baerlocher, Isabel Roditi, Torsten Ochsenreiter
Publikováno v:
PLoS Pathogens, Vol 6, Iss 8, p e1001037 (2010)
Trans-splicing of leader sequences onto the 5'ends of mRNAs is a widespread phenomenon in protozoa, nematodes and some chordates. Using parallel sequencing we have developed a method to simultaneously map 5'splice sites and analyze the corresponding
Externí odkaz:
https://doaj.org/article/4131424e46b74a5cbde90999bf8b618d
Publikováno v:
Journal of Biological Chemistry. 292:3400-3410
The mitochondrial outer membrane (OM) contains single and multiple membrane-spanning proteins which need to contain signals that ensure correct targeting and insertion into the OM. The biogenesis of such proteins has so far essentially only been stud
Autor:
Silke Oeljeklaus, Moritz Niemann, Benoît Zuber, Bernd Schimanski, Julia Bruggisser, Iosif Kaurov, André Schneider, Julius Lukeš, Beat Haenni, Bettina Warscheid, Claudia Eichenberger, Hassan Hashimi, Jan Mani
Publikováno v:
Eichenberger, Claudia; Oeljeklaus, Silke; Bruggisser, Julia Maria; Mani, Jan; Haenni, Beat; Kaurov, Iosif; Niemann, Moritz; Zuber, Benoît; Lukeš, Julius; Hashimi, Hassan; Warscheid, Bettina; Schimanski, Bernd; Schneider, André (2019). The highly diverged trypanosomal MICOS complex is organized in a non-essential integral membrane and an essential peripheral module. Molecular microbiology, 112(6), pp. 1731-1743. Wiley 10.1111/mmi.14389
The mitochondrial contact site and cristae organization system (MICOS) mediates the formation of cristae, invaginations in the mitochondrial inner membrane. The highly diverged MICOS complex of the parasitic protist Trypanosoma brucei consists of nin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d6b3175e0a335b108f4c8b70931c81
Publikováno v:
Molecular Microbiology. 102:520-529
TbLOK1 has previously been characterized as a trypanosomatid-specific mitochondrial outer membrane protein whose ablation caused a collapse of the mitochondrial network, disruption of the membrane potential and loss of mitochondrial DNA. Here we show
Publikováno v:
Molecular Biology and Evolution. 33:337-351
Mitochondria are essential for eukaryotic life and more than 95% of their proteins are imported as precursors from the cytosol. The targeting signals for this posttranslational import are conserved in all eukaryotes. However, this conservation does n
Autor:
Richard Wagner, Jan Mani, Moritz Niemann, Silke Oeljeklaus, André Schneider, Christian D. Peikert, Anke Judith Harsman, Bettina Warscheid
Publikováno v:
Proceedings of the National Academy of Sciences
Mitochondrial tRNA import is widespread, but the mechanism by which tRNAs are imported remains largely unknown. The mitochondrion of the parasitic protozoan Trypanosoma brucei lacks tRNA genes, and thus imports all tRNAs from the cytosol. Here we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f29c458fdcf1a8b2f321f36c7f0d51d