Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jan, Ludwiczak"'
Autor:
Ewelina Latoszek, Małgorzata Wiweger, Jan Ludwiczak, Stanisław Dunin-Horkawicz, Jacek Kuznicki, Magdalena Czeredys
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-21 (2022)
Abstract Background Huntington’s disease (HD) is a neurodegenerative disorder whereby mutated huntingtin protein (mHTT) aggregates when polyglutamine repeats in the N-terminal of mHTT exceeds 36 glutamines (Q). However, the mechanism of this pathol
Externí odkaz:
https://doaj.org/article/9b3533a3508447458b8945b149bdaa0e
Autor:
Matthew Merski, Krzysztof Młynarczyk, Jan Ludwiczak, Jakub Skrzeczkowski, Stanisław Dunin-Horkawicz, Maria W. Górna
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-17 (2020)
Abstract Background Protein repeats can confound sequence analyses because the repetitiveness of their amino acid sequences lead to difficulties in identifying whether similar repeats are due to convergent or divergent evolution. We noted that the pa
Externí odkaz:
https://doaj.org/article/3cca44e4605d4ae7bd5419acd714b0e4
Autor:
Anna Marta Banaś, Katarzyna Marta Bocian-Ostrzycka, Maciej Plichta, Stanisław Dunin-Horkawicz, Jan Ludwiczak, Jagoda Płaczkiewicz, Elżbieta Katarzyna Jagusztyn-Krynicka
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230366 (2020)
Posttranslational generation of disulfide bonds catalyzed by bacterial Dsb (disulfide bond) enzymes is essential for the oxidative folding of many proteins. Although we now have a good understanding of the Escherichia coli disulfide bond formation sy
Externí odkaz:
https://doaj.org/article/239ad0f3be7841e6b4d680c72bdca5c3
Autor:
Aleksander Winski, Jan Ludwiczak, Malgorzata Orlowska, Rafal Madaj, Kamil Kaminski, Stanislaw Dunin-Horkawicz
Computational modeling of protein structures that adopt multiple conformations is a challenging task. We propose a procedure for generalizing the knowledge gained from AlphaFold2 models to represent such conformational landscapes. The procedure was a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39d83809192500fe93d0552540618710
https://doi.org/10.1101/2023.05.23.541686
https://doi.org/10.1101/2023.05.23.541686
SummaryHomology detection by sequence comparison is a typical first step in the study of protein function and evolution. Here, we describe a new homology detection tool, pLM-BLAST, that uses a modified Smith-Waterman algorithm for unsupervised compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dcb65e4d2ce4e303f90d61852f631cf
https://doi.org/10.1101/2022.11.24.517862
https://doi.org/10.1101/2022.11.24.517862
Publikováno v:
Bioinformatics. 38:2633-2635
Motivation The wealth of protein structures collected in the Protein Data Bank enabled large-scale studies of their function and evolution. Such studies, however, require the generation of customized datasets combining the structural data with miscel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6626c3ad4aec191135b7bbd134d717d5
https://doi.org/10.1093/bioinformatics/btac121
https://doi.org/10.1093/bioinformatics/btac121
Autor:
Mariusz Berdyński, Jan Ludwiczak, Anna Barczak, Maria Barcikowska-Kotowicz, Magdalena Kuźma-Kozakiewicz, Stanisław Dunin-Horkawicz, Cezary Żekanowski, Beata Borzemska
Publikováno v:
Journal of Alzheimer's disease : JAD. 89(4)
Background: Homozygous variants of the TREM2 and TYROBP genes have been shown to be causative for multiple bone cysts and neurodegeneration leading to progressive dementia (NHD, Nasu-Hakola disease). Objective: To determine if biallelic variants of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddadd22a84c4d0770bddcbc155e10b1
https://pubmed.ncbi.nlm.nih.gov/36031890
https://pubmed.ncbi.nlm.nih.gov/36031890
Autor:
E. Sitkiewicz, Stanislaw Dunin-Horkawicz, G. Goch, Maciej Jasiński, Ewa Lewicka, Jan Ludwiczak, B. Swiderska, Grazyna Jagura-Burdzy, Malgorzata Adamczyk, H. Nieznanska, Roza Szatkowska
Publikováno v:
BMC Microbiology, Vol 21, Iss 1, Pp 1-16 (2021)
BMC Microbiology
BMC Microbiology
Background DNA binding KfrA-type proteins of broad-host-range bacterial plasmids belonging to IncP-1 and IncU incompatibility groups are characterized by globular N-terminal head domains and long alpha-helical coiled-coil tails. They have been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd996d0ca2cc83aa3f9d5f04c30774db
https://doaj.org/article/e6faf88eca5d492fb54099ffe750885a
https://doaj.org/article/e6faf88eca5d492fb54099ffe750885a
Autor:
Antonio Marinho da Silva Neto, Jan Ludwiczak, Stanislaw Dunin-Horkawicz, Adriana Bukala, Krzysztof Szczepaniak
Publikováno v:
Bioinformatics
Motivation Coiled coils are widespread protein domains involved in diverse processes ranging from providing structural rigidity to the transduction of conformational changes. They comprise two or more α-helices that are wound around each other to fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4978071d808867056ba11f50f61e2b4f
https://doi.org/10.1093/bioinformatics/btaa1041
https://doi.org/10.1093/bioinformatics/btaa1041
Autor:
Ewelina Latoszek, Małgorzata Wiweger, Jan Ludwiczak, Stanisław Dunin-Horkawicz, Jacek Kuznicki, Magdalena Czeredys
Publikováno v:
Cellbioscience. 12(1)
Background Huntington’s disease (HD) is a neurodegenerative disorder whereby mutated huntingtin protein (mHTT) aggregates when polyglutamine repeats in the N-terminal of mHTT exceeds 36 glutamines (Q). However, the mechanism of this pathology is un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761825c63491835916a3e1a7ac2aa69c
https://pubmed.ncbi.nlm.nih.gov/35305696
https://pubmed.ncbi.nlm.nih.gov/35305696