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Autor: Jan Lessem, Ann-Marie Roos-Jansåker, Stefan Renvert, Christel Lindahl

Publikováno v: Journal of Clinical Periodontology. 36:1-39

Background: Periodontal disease affect a large proportion of the adult population and cause an increasein serum levels of C- reactive protein (CRP), and other markers of inflammation. An increased level of CRP reflects an increased risk of cardiovasc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e59c95b52327455ccd3e5d3cb7dd12e
https://doi.org/10.1111/j.1600-051x.2009.01403.x

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Short-Term Effects of an Anti-Inflammatory Treatment on Clinical Parameters and Serum Levels of C-Reactive Protein and Proinflammatory Cytokines in Subjects With Periodontitis

Autor: Christel Lindahl, Ann-Marie Roos-Jansåker, Stefan Renvert, Jan Lessem

Publikováno v: Journal of Periodontology. 80:892-900

Background: Periodontal disease is the most common multifactorial disease, afflicting a very large proportion of the adult population. Periodontal disease secondarily causes increases in the serum levels of C-reactive protein (CRP) and other markers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27100ffd9ee16730c96099992afed7b2
https://doi.org/10.1902/jop.2009.080552

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Myocardial Scintigraphy with 99mTc-Pyrophosphate in Patients with Unstable Angina Pectoris

Autor: Bengt W. Johansson, Jan Lessem, Bertil Nosslin, Jan I. Thorell

Publikováno v: Acta Medica Scandinavica. 203:491-495

A total of 400 patients, aged 25–82 years, admitted to the Coronary Care Unit due to clinical suspicion of acute myocardial infarction, were examined with 10 mCi 99mTc labelled to pyrophosphate. The examinations were carried out 4–120 hours post

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08d04627d29ec275f1e049c127a5cdc
https://doi.org/10.1111/j.0954-6820.1978.tb14914.x

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Combined Therapy with Ca-Antagonists and Beta-Adrenergic Receptor Blocking Agents in Chronic Stable Angina

Autor: Jan Lessem

Publikováno v: Acta Medica Scandinavica. 215:83-90

Summary There have been conflicting reports on the safety of combining betaadrenergic receptor blockers and Ca++ -antagonists, especially verapamil, in the treatment of cardiovascular diseases. Warnings have been raised against additive negative chro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef352d02d3c66d9f5bffb3935c08c72d
https://doi.org/10.1111/j.0954-6820.1984.tb08681.x

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Mechanical and Repeated Antimicrobial Therapy Using a Local Drug Delivery System in the Treatment of Peri-Implantitis: A Randomized Clinical Trial

Autor: Jan Lessem, Christel Lindahl, Helena Renvert, Gunnar Dahlén, Stefan Renvert

Publikováno v: Journal of Periodontology. 79:836-844

BACKGROUND: Peri-implantitis is an inflammatory process caused by microorganisms affecting the tissues around an osseointegrated implant in function, resulting in a loss of supporting bone. Limited data exist regarding the treatment of peri-implantit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2bf1b64d81d0c7afa5c500b71d579a
https://doi.org/10.1902/jop.2008.070347

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Clinical Relevance of Adjunctive Minocycline Microspheres in Patients With Chronic Periodontitis: Secondary Analysis of a Phase 3 Trial

Autor: Alexandra L. Hanlon, Ray C. Williams, Jan Lessem, David W. Paquette

Publikováno v: Journal of Periodontology. 75:531-536

A recent Phase 3 trial demonstrated that adjunctive treatment with minocycline microspheres resulted in significant reductions in patient mean probing depths as compared to scaling and root planing (SRP) alone. The objective of the present study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a289dc1e38bebe777205da69d41305e4
https://doi.org/10.1902/jop.2004.75.4.531

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Locally delivered minocycline microspheres for the treatment of periodontitis in smokers

Autor: Edward A. Santucci, Steven Offenbacher, Richard J. Oringer, Jan Lessem, David W. Paquette, Robert J. Genco, G. Rutger Persson, Ray C. Williams

Publikováno v: Journal of Clinical Periodontology. 30:787-794

Aim: The aim of the present analysis of a larger phase 3 clinical trial was to evaluate the efficacy of 1 mg minocycline hydrochloride microencapsulated in 3 mg of resorbable polymer, subgingivally administered as an adjunct to scaling and root plani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38a869346b1ef1adef617828e8e454d5
https://doi.org/10.1034/j.1600-051x.2003.00375.x

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Mechanisms and clinical effects of thiazolidinediones

Autor: Scott L Grossman, Jan Lessem

Publikováno v: Expert Opinion on Investigational Drugs. 6:1025-1040

Studies of pioglitazone, troglitazone, BRL 49653 and other thiazolidinediones in preclinical animal models of non-insulin dependent diabetes mellitus (NIDDM) and obesity led to the observation that these compounds were effective in reducing hyperglyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a8912c0a7af4bfe523e32c8b838bc8
https://doi.org/10.1517/13543784.6.8.1025

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