Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Jan, Kranich"'
Autor:
Peter A. Tauber, Bernhard Kratzer, Philipp Schatzlmaier, Ursula Smole, Cordula Köhler, Lisa Rausch, Jan Kranich, Doris Trapin, Alina Neunkirchner, Maja Zabel, Sabrina Jutz, Peter Steinberger, Gabriele Gadermaier, Thomas Brocker, Hannes Stockinger, Sophia Derdak, Winfried F. Pickl
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundTreg cells have been shown to be an important part of immune-homeostasis and IL-2 which is produced upon T cell receptor (TCR)-dependent activation of T lymphocytes has been demonstrated to critically participate in Treg development.Objecti
Externí odkaz:
https://doaj.org/article/00251fce79eb4bce8c93560542f17e14
Autor:
Lisa Rausch, Konstantin Lutz, Martina Schifferer, Elena Winheim, Rudi Gruber, Elina F. Oesterhaus, Linus Rinke, Johannes C. Hellmuth, Clemens Scherer, Maximilian Muenchhoff, Christopher Mandel, Michael Bergwelt‐Baildon, Mikael Simons, Tobias Straub, Anne B. Krug, Jan Kranich, Thomas Brocker
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 14, Pp n/a-n/a (2021)
Abstract Infection with SARS‐CoV‐2 is associated with thromboinflammation, involving thrombotic and inflammatory responses, in many COVID‐19 patients. In addition, immune dysfunction occurs in patients characterised by T cell exhaustion and sev
Externí odkaz:
https://doaj.org/article/90e56d7dcd8c4e7da4606b3b096736f2
Autor:
Elena Winheim, Linus Rinke, Konstantin Lutz, Anna Reischer, Alexandra Leutbecher, Lina Wolfram, Lisa Rausch, Jan Kranich, Paul R Wratil, Johanna E Huber, Dirk Baumjohann, Simon Rothenfusser, Benjamin Schubert, Anne Hilgendorff, Johannes C Hellmuth, Clemens Scherer, Maximilian Muenchhoff, Michael von Bergwelt-Baildon, Konstantin Stark, Tobias Straub, Thomas Brocker, Oliver T Keppler, Marion Subklewe, Anne B Krug
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009742 (2021)
Disease manifestations in COVID-19 range from mild to severe illness associated with a dysregulated innate immune response. Alterations in function and regeneration of dendritic cells (DCs) and monocytes may contribute to immunopathology and influenc
Externí odkaz:
https://doaj.org/article/852e03dd622546c7b68aaac8583d6fbd
Autor:
Anne Trefzer, Pallavi Kadam, Shu-Hung Wang, Stefanie Pennavaria, Benedikt Lober, Batuhan Akçabozan, Jan Kranich, Thomas Brocker, Naoko Nakano, Martin Irmler, Johannes Beckers, Tobias Straub, Reinhard Obst
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108748- (2021)
Summary: Exhausted immune responses to chronic diseases represent a major challenge to global health. We study CD4+ T cells in a mouse model with regulatable antigen presentation. When the cells are driven through the effector phase and are then expo
Externí odkaz:
https://doaj.org/article/591264a4d4324b9a8794cbb7e208457b
Autor:
Jan Kranich, Nikolaos-Kosmas Chlis, Lisa Rausch, Ashretha Latha, Martina Schifferer, Tilman Kurz, Agnieszka Foltyn-Arfa Kia, Mikael Simons, Fabian J. Theis, Thomas Brocker
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
The in vivo detection of dead cells remains a major challenge due to technical hurdles. Here, we present a novel method, where injection of fluorescent milk fat globule-EGF factor 8 protein (MFG-E8) in vivo combined with imaging flow cytometry and de
Externí odkaz:
https://doaj.org/article/1af123df552b4e0498a37dad5f4202d8
Autor:
Lisa Rausch, Lavinia Flaskamp, Ashretha Ashokkumar, Anne Trefzer, Christine Ried, Veit R. Buchholz, Reinhard Obst, Tobias Straub, Thomas Brocker, Jan Kranich
Publikováno v:
Proceedings of the National Academy of Sciences. 120
CD8 + T cells are crucial for the clearance of viral infections. During the acute phase, proinflammatory conditions increase the amount of circulating phosphatidylserine + (PS) extracellular vesicles (EVs). These EVs interact especially with CD8 + T
Autor:
Rainer Kaiser, Afra Anjum, Lisa Maria Kammerer, Quentin Loew, Anastassia Akhalkatsi, Dario Rossaro, Raphael Escaig, Augustin Droste zu Senden, Ben Raude, Michael Lorenz, Christoph Gold, Kami Pekayvaz, Thomas Brocker, Jan Kranich, Julian Walter Holch, Karsten Spiekermann, Steffen Massberg, Florian Gaertner, Leo Nicolai
Publikováno v:
Blood.
Platelets are first responders in thrombosis and hemostasis, but also central players in inflammation. Compared to platelets recruited to thrombi, immune-responsive platelets use distinct effector functions including Arp2/3-dependent migration along
Autor:
Isabel Meininger, Richard A. Griesbach, Desheng Hu, Torben Gehring, Thomas Seeholzer, Arianna Bertossi, Jan Kranich, Andrea Oeckinghaus, Andrea C. Eitelhuber, Ute Greczmiel, Andreas Gewies, Marc Schmidt-Supprian, Jürgen Ruland, Thomas Brocker, Vigo Heissmeyer, Florian Heyd, Daniel Krappmann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
MALT1 regulates NFκB signalling both as a scaffolding protein and as a protease. Here the authors show that during T cell activation the expression of MALT1 gene switches to an alternatively spliced variant, which increases TCR signal transduction d
Externí odkaz:
https://doaj.org/article/b82a72dd5f0a44099bcaaa35fbf30349
Predicting single-cell gene expression profiles of imaging flow cytometry data with machine learning
Publikováno v:
Nucleic Acids Res. 48, 11335-11346 (2020)
Nucleic Acids Research
Nucleic Acids Research
High-content imaging and single-cell genomics are two of the most prominent high-throughput technologies for studying cellular properties and functions at scale. Recent studies have demonstrated that information in large imaging datasets can be used
Autor:
Rainer Kaiser, Raphael Escaig, Jan Kranich, Marie-Louise Hoffknecht, Afra Anjum, Vivien Polewka, Magdalena Mader, Wenbo Hu, Larissa Belz, Christoph Gold, Anna Titova, Michael Lorenz, Kami Pekayvaz, Stefan Kääb, Florian Gaertner, Konstantin Stark, Thomas Brocker, Steffen Massberg, Leo Nicolai
Publikováno v:
Blood
Impairment of vascular integrity is a hallmark of inflammatory diseases. We recently reported that single immune-responsive platelets migrate and reposition themselves to sites of vascular injury to prevent bleeding. However, it remains unclear how s