Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jan, Krützfeldt"'
Publikováno v:
Molecular Metabolism, Vol 71, Iss , Pp 101704- (2023)
Objective: Skeletal muscle regeneration is markedly impaired during aging. How adult muscle stem cells contribute to this decrease in regenerative capacity is incompletely understood. We investigated mechanisms of age-related changes in myogenic prog
Externí odkaz:
https://doaj.org/article/5110bbb72eab4a0aa2b7687196878f66
Publikováno v:
Biomolecules, Vol 13, Iss 3, p 497 (2023)
Biomarkers are important tools to improve the early detection of patients at high risk for developing diabetes as well as the stratification of diabetic patients towards risks of complications. In addition to clinical variables, we analyzed 155 metab
Externí odkaz:
https://doaj.org/article/e88f6f016c5745759c62f271d1ddb3fc
Autor:
Alexandra Fahrner, Nikoleta Alchus Laiferová, Barbara Ukropcová, Jozef Ukropec, Jan Krützfeldt
Context Type 2 diabetes mellitus (T2D) negatively affects muscle mass and function throughout life. Whether adult muscle stem cells contribute to the decrease in muscle health is not clear and insights into the stem cell niche are difficult to obtain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db22c1e23f5cd01e577cc7185d671564
https://www.zora.uzh.ch/id/eprint/228745/
https://www.zora.uzh.ch/id/eprint/228745/
Autor:
Edlira Luca, Katarina Turcekova, Angelika Hartung, Sebastian Mathes, Hubert Rehrauer, Jan Krützfeldt
Publikováno v:
Molecular Metabolism, Vol 36, Iss , Pp - (2020)
Objective: Decreased muscle mass is a major contributor to age-related morbidity, and strategies to improve muscle regeneration during ageing are urgently needed. Our aim was to identify the subset of relevant microRNAs (miRNAs) that partake in criti
Externí odkaz:
https://doaj.org/article/9454546878324ec59fccba92a7f79729
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 2, Pp 384-399 (2018)
Abstract Background Intramuscular fatty infiltration is generally associated with the accumulation of white adipocytes in skeletal muscle and unfavourable metabolic outcomes. It is, however, still unclear whether intramuscular adipocytes could also a
Externí odkaz:
https://doaj.org/article/a2a9f1c8af394cf6a0e9da050b024135
Publikováno v:
Journal of molecular medicine (Berlin, Germany). 100(11)
Abstract Skeletal muscle exerts many beneficial effects on the human body including the contraction-dependent secretion of peptides termed myokines. We have recently connected the myokine secreted protein acidic and rich in cysteine (SPARC) to the fo
Autor:
Sandra, Goetze, Kathrin, Frey, Lucia, Rohrer, Silvija, Radosavljevic, Jan, Krützfeldt, Ulf, Landmesser, Marco, Bueter, Patrick G A, Pedrioli, Arnold, von Eckardstein, Bernd, Wollscheid
Publikováno v:
Journal of proteome research. 20(11)
High-density lipoprotein (HDL) is a heterogeneous mixture of blood-circulating multimolecular particles containing many different proteins, lipids, and RNAs. Recent advancements in mass spectrometry-based proteotype analysis show promise for the anal
OR24-1 Paracrine Growth Factor Signaling Regulates Muscle Regeneration in Aged Mice via microRNA 501
Autor:
Jan Krützfeldt, Alexandra Fahrner
Publikováno v:
Journal of the Endocrine Society. 6:A351-A351
Background Skeletal muscle is one of to the most dynamic and plastic tissues. The capacity to regenerate arises from adult muscle stem cells termed myogenic progenitors (MPs) that are activated in response to injury and differentiate to replenish dam
Autor:
Alexandra Fahrner, Jan Krützfeldt, Christian Wolfrum, Hannes A. Rüdiger, Michael Leunig, Umesh Ghoshdastider, Sebastian Mathes
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 118 (37)
Proceedings of the National Academy of Sciences of the United States of America, 118 (37)
Aged skeletal muscle is markedly affected by fatty muscle infiltration, and strategies to reduce the occurrence of intramuscular adipocytes are urgently needed. Here, we show that fibroblast growth factor-2 (FGF-2) not only stimulates muscle growth b
Autor:
Marian Hruska-Plochan, Bei Li, Diego Kyburz, Jan Krützfeldt, Ulf Landmesser, Adriano Aguzzi, Magdalini Polymenidou
Publikováno v:
Swiss Medical Weekly, Vol 145, Iss 3738 (2015)
Small noncoding RNAs (snRNAs) were discovered more than two decades ago, yet it was not until relatively recently that their important role in genome regulation was recognised. With such a substantial role in genome regulation, it is not surprising t
Externí odkaz:
https://doaj.org/article/1f06a70e30c7485c9e67e2071f23353e