Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Jan, Korabecny"'
Autor:
Marketa Chvojkova, David Kolar, Katarina Kovacova, Lada Cejkova, Anna Misiachna, Kristina Hakenova, Lukas Gorecki, Martin Horak, Jan Korabecny, Ondrej Soukup, Karel Vales
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116821- (2024)
Therapeutic options for Alzheimer’s disease are limited. Dual compounds targeting two pathways concurrently may enable enhanced effect. The study focuses on tacrine derivatives inhibiting acetylcholinesterase (AChE) and simultaneously N-methyl-D-as
Externí odkaz:
https://doaj.org/article/ba09458e987a4172bb5b911d5bb2a16e
Autor:
Eva Mezeiova, Lukas Prchal, Martina Hrabinova, Lubica Muckova, Lenka Pulkrabkova, Ondrej Soukup, Anna Misiachna, Jiri Janousek, Jakub Fibigar, Tomas Kucera, Martin Horak, Galina F. Makhaeva, Jan Korabecny
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116399- (2024)
The search for novel drugs to address the medical needs of Alzheimer's disease (AD) is an ongoing process relying on the discovery of disease-modifying agents. Given the complexity of the disease, such an aim can be pursued by developing so-called mu
Externí odkaz:
https://doaj.org/article/567776fbc85843eba2bb66f04d9469c0
Autor:
Xueqin Huang, Li You, Eugenie Nepovimova, Miroslav Psotka, David Malinak, Marian Valko, Ladislav Sivak, Jan Korabecny, Zbynek Heger, Vojtech Adam, Qinghua Wu, Kamil Kuca
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Phosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein kinases (PIKK) are two structurally related families of kinases that play vital roles in cell growth and DNA damage repair. Dysfunction of PIKK members and aberrant stimu
Externí odkaz:
https://doaj.org/article/2625c42c0d07439f92419713efaf92ad
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S426-S427 (2023)
Externí odkaz:
https://doaj.org/article/f32fd60a04004897ba8b70b1e52c5744
Autor:
Zofia Chrienova, Eugenie Nepovimova, Rudolf Andrys, Rafael Dolezal, Jana Janockova, Lubica Muckova, Lenka Fabova, Ondrej Soukup, Patrik Oleksak, Martin Valis, Jan Korabecny, José Marco-Contelles, Kamil Kuca
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2605-2620 (2022)
Twenty-four novel compounds bearing tetrahydroacridine and N-propargyl moieties have been designed, synthesised, and evaluated in vitro for their anti-cholinesterase and anti-monoamine oxidase activities. Propargyltacrine 23 (IC50 = 21 nM) was the mo
Externí odkaz:
https://doaj.org/article/1b4b604d4ed2463eadfec515d42a5564
Autor:
Barbora Svobodova, Lenka Pulkrabkova, Dawid Panek, Anna Misiachna, Marharyta Kolcheva, Rudolf Andrys, Jiri Handl, Jan Capek, Pavlina Nyvltova, Tomas Rousar, Lukas Prchal, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Daniela Tosnerova, Galina Karabanovich, Vladimir Finger, Ondrej Soukup, Martin Horak, Jan Korabecny
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9124 (2023)
Alzheimer’s disease (AD) is a complex disease with an unknown etiology. Available treatments, limited to cholinesterase inhibitors and N-methyl-d-aspartate receptor (NMDAR) antagonists, provide symptomatic relief only. As single-target therapies ha
Externí odkaz:
https://doaj.org/article/5997ebc1604b46dfa3bcaf7b7054b542
Autor:
David Malinak, Rafael Dolezal, Vendula Hepnarova, Miroslava Hozova, Rudolf Andrys, Petr Bzonek, Veronika Racakova, Jan Korabecny, Lukas Gorecki, Eva Mezeiova, Miroslav Psotka, Daniel Jun, Kamil Kuca, Kamil Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 478-488 (2020)
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE
Externí odkaz:
https://doaj.org/article/4eaa3b83e7db43c89b59bdfb119cb77b
Autor:
Jana Janockova, Jan Korabecny, Jana Plsikova, Katerina Babkova, Eva Konkolova, Dana Kucerova, Jana Vargova, Jan Koval, Rastislav Jendzelovsky, Peter Fedorocko, Jana Kasparkova, Viktor Brabec, Jan Rosocha, Ondrej Soukup, Slavka Hamulakova, Kamil Kuca, Maria Kozurkova
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 877-897 (2019)
A combination of biochemical, biophysical and biological techniques was used to study calf thymus DNA interaction with newly synthesized 7-MEOTA-tacrine thiourea 12–17 and urea heterodimers 18–22, and to measure interference with type I and II to
Externí odkaz:
https://doaj.org/article/6487d4fed0064893867020e3dda083eb
Autor:
Ondrej Soukup, Jan Korabecny
Publikováno v:
Toxics, Vol 10, Iss 8, p 444 (2022)
The scope of this Special Issue is to pay attention to various aspects of toxicology specifically focused on the chemical and biological threats, which may accidentally, or on purpose, endanger human health [...]
Externí odkaz:
https://doaj.org/article/d60a4afa040a4b63ac733eee4805680a
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Natalia P. Boltneva, Elena V. Rudakova, Sofya V. Lushchekina, Tatiana Yu. Astakhova, Igor V. Serkov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Jan Korabecny, Ondrej Soukup, Sergey O. Bachurin, Rudy J. Richardson
Publikováno v:
Molecules, Vol 27, Iss 3, p 1060 (2022)
Using two ways of functionalizing amiridine—acylation with chloroacetic acid chloride and reaction with thiophosgene—we have synthesized new homobivalent bis-amiridines joined by two different spacers—bis-N-acyl-alkylene (3) and bis-N-thiourea-
Externí odkaz:
https://doaj.org/article/90ae90fd4e9f4057a738309e4978db2b