Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Jan, Kopecký"'
Autor:
Zuzana Beránková, Ritesh Khanna, Markéta Spěváková, Helena Langhansová, Jan Kopecký, Jaroslava Lieskovská
Publikováno v:
Ticks and Tick-Borne Diseases, Vol 15, Iss 1, Pp 102269- (2024)
Viral infection may represent a stress condition to the host cell. Cells react to it by triggering the defence programme to restore homeostasis and these events may in turn impact the viral replication. The knowledge about tick-borne encephalitis vir
Externí odkaz:
https://doaj.org/article/2aa11dd396f5406cae8672fc9230d7ab
Autor:
Helena L Fisk, Caroline E Childs, Elizabeth A Miles, Robert Ayres, Paul S Noakes, Carolina Paras-Chavez, Ondrej Kuda, Jan Kopecký, Elie Antoun, Karen A Lillycrop, Philip C Calder
Publikováno v:
EBioMedicine, Vol 77, Iss , Pp 103909- (2022)
Summary: Background: Obesity is associated with enhanced inflammation. However, investigation in human subcutaneous white adipose tissue (scWAT) is limited and the mechanisms by which inflammation occurs have not been well elucidated. Marine long cha
Externí odkaz:
https://doaj.org/article/eeea09af131447a1a9db2d2f8b6713f8
Autor:
Jan Kopecký
Publikováno v:
Medicína pro praxi. 19:215-219
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f15e244a25deec6571fdc568f8919d42
https://doi.org/10.36290/med.2022.035
https://doi.org/10.36290/med.2022.035
Autor:
Ana Carreras-González, Diego Barriales, Ainhoa Palacios, Marta Montesinos-Robledo, Nicolás Navasa, Mikel Azkargorta, Ainize Peña-Cearra, Julen Tomás-Cortázar, Iraide Escobes, Miguel Angel Pascual-Itoiz, Jana Hradiská, Jan Kopecký, David Gil-Carton, Rafael Prados-Rosales, Leticia Abecia, Estíbaliz Atondo, Itziar Martín, Aize Pellón, Félix Elortza, Héctor Rodríguez, Juan Anguita
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008163 (2019)
Macrophages mediate the elimination of pathogens by phagocytosis resulting in the activation of specific signaling pathways that lead to the production of cytokines, chemokines and other factors. Borrelia burgdorferi, the causative agent of Lyme dise
Externí odkaz:
https://doaj.org/article/d8deb873369c409392d9efe0a2b2952b
Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes
Autor:
Jaroslava Lieskovská, Jana Páleníková, Helena Langhansová, Andrezza Campos Chagas, Eric Calvo, Michalis Kotsyfakis, Jan Kopecký
Publikováno v:
Parasites & Vectors, Vol 8, Iss 1, Pp 1-11 (2015)
Abstract Background Transmission of pathogens by ticks is greatly supported by tick saliva released during feeding. Dendritic cells (DC) act as immunological sentinels and interconnect the innate and adaptive immune system. They control polarization
Externí odkaz:
https://doaj.org/article/25ed7fd72f424301b2036b350633e2cd
Autor:
Elie Antoun, Helena L. Fisk, Caroline E. Childs, Elizabeth A. Miles, Carolina Paras-Chavez, Philip C. Calder, Karen A. Lillycrop, Robert Ayres, Ondrej Kuda, Paul S. Noakes, Jan Kopecký
Publikováno v:
Clinical Science. 135:185-200
Obesity is believed to be associated with a dysregulated endocannabinoid system which may reflect enhanced inflammation. However, reports of this in human white adipose tissue (WAT) are limited and inconclusive. Marine long-chain omega-3 polyunsatura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe22ddf58c25c8723bde9c17e055146
https://doi.org/10.1042/cs20201060
https://doi.org/10.1042/cs20201060
Publikováno v:
Virus research. 315
Autophagy is a lysosomal degradative pathway responsible for recycling cytosolic proteins and organelles and also functions as an innate defense mechanism that host cells use against viral infection. While many viruses have evolved mechanisms to anta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759564860b9798e1c336fbe501b5013b
https://pubmed.ncbi.nlm.nih.gov/35421435
https://pubmed.ncbi.nlm.nih.gov/35421435
Autor:
Edgar Schmitt, Natascha Stergiou, Helena Langhansová, Eric Calvo, Michail Kotsyfakis, Alexandra Schwarz, Jan Kotál, Michael Mareš, Zuzana Beránková, Jan Kopecký, Pavlína Řezáčová, Adéla Chlastáková, Jindřich Chmelař, Michal Buša
Publikováno v:
Cellular and Molecular Life Sciences. 76:2003-2013
To successfully feed, ticks inject pharmacoactive molecules into the vertebrate host including cystatin cysteine protease inhibitors. However, the molecular and cellular events modulated by tick saliva remain largely unknown. Here, we describe and ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86b33541ef7165df6258ab5640f7cb7
https://doi.org/10.1007/s00018-019-03034-3
https://doi.org/10.1007/s00018-019-03034-3
Autor:
Tereza Janotová, Marie Jalovecká, Marie Auerová, Ivana Švecová, Pavlína Bruzlová, Veronika Maierová, Zuzana Kumžáková, Štěpánka Cunátová, Zuzana Vlčková, Veronika Caisová, Petra Rozsypalová, Katarína Lukáčová, Nikol Vácová, Markéta Wachtlová, Jiří Salát, Jaroslava Lieskovská, Jan Kopecký, Jan Ženka
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85222 (2014)
The application of the phagocytic receptor agonists in cancer immunotherapy was studied. Agonists (laminarin, molecules with terminal mannose, N-Formyl-methioninyl-leucyl-phenylalanine) were firmly anchored to the tumor cell surface. When particular
Externí odkaz:
https://doaj.org/article/15e8dac302a14b87944b9172e716848c
Autor:
Stanislav Kadlčík, Tomáš Kučera, Dominika Chalupská, Radek Gažák, Markéta Koběrská, Dana Ulanová, Jan Kopecký, Eva Kutejová, Lucie Najmanová, Jiří Janata
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84902 (2013)
Clinically used lincosamide antibiotic lincomycin incorporates in its structure 4-propyl-L-proline (PPL), an unusual amino acid, while celesticetin, a less efficient related compound, makes use of proteinogenic L-proline. Biochemical characterization
Externí odkaz:
https://doaj.org/article/83cc7ae4327c40cba4c12fbed16d3349