Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial

Autor: Renato D. Lopes, Celestia S. Higano, Susan F. Slovin, Adam J. Nelson, Robert Bigelow, Per S. Sørensen, Chiara Melloni, Shaun G. Goodman, Christopher P. Evans, Jan Nilsson, Deepak L. Bhatt, Noel W. Clarke, Tine K. Olesen, Belinda T. Doyle-Olsen, Henriette Kristensen, Lauren Arney, Matthew T. Roe, John H. Alexander, Mirjam Mol-Arts, Samreen Mansor-Lefebvre, Konstantin Zubovskiy, Allan Blemings, Klaus Dugi, Gerald Bloomfield, Chris Kontos, Adam DeVore, Dedrick Jordan, Bradley Kolls, Robin Matthews, Rajendra Mehta, Thomas J. Povsic, Michael Morse, Kenneth W. Mahaffey, Susan Halabi, Darryl Leong, Laurence Klotz, Neil Fleshner, Godfrey Jansz, Jonathan Giddens, Russell Egerdie, Joseph Chin, Joseph Zadra, Richard Casey, Jean Simard, Tamim Niazi, André-Guy Martin, Marek Babjuk, Jaroslav Hajek, Jiri Klecka, Jiri Kubes, Jan Schraml, Jitka Jakesova, Jaroslav Vanasek, Bohuslav Melichar, Heikki Seikkula, Manouar Samir Abdiche, Marc Colombel, Philippe Debourdeau, Gregoire Robert, Arnauld Villers, Guillaume Ploussard, Benjamin Pradere, Franck Bruyere, Jean-Luc Descotes, Idir Ouzaid, Alexander Winter, Herbert Hanitzsch, Herbert Sperling, Ralf Eckert, Peter Hammerer, Elke Stagge, Florian Seseke, Silvio Szymula, Aristotelis Bamias, Anastasios Thanos, Konstantinos Hatzimouratidis, Charalambos Mamoulakis, Haralabos Kalofonos, Elzbieta Oszukowska, Katarzyna Madziarska, Jacek Fijuth, Mateusz Obarzanowski, Boris Alekseev, Vagif Atduev, Dmitri Pushkar, Evgeniy Veliev, Alexander Zyryanov, Sergey Petrov, Evgeny Kopyltsov, Vadim Kozlov, Ladislav Macko, Jozef Dubravicky, Richard Polak, Obaidullah Mir, Marek Vargovcak, Ivan Mincik, Jan Kliment, Frederico Goncalves, Juraj Mikulas, Roman Sokol, Michal Korcek, Jozef Marko, Viktor Kovacik, Igor Milichovsky, Pavol Dubinsky, John Lazarus, Sanjay Dixit, Euan Green, Rajaguru Srinivasan, Danish Mazhar, Yeung Ng, Naveed Sarwar, Craig Herman, Frederick Snoy, Robert Given, Ronald Suh, David Lipsitz, James Bailen, Lawrence Gervasi, Idalia Acosta, Laurence Belkoff, Ning Wu, Jeffrey Frankel, Lawrence Karsh, Bryant Poole, David Lieber, Jason Engel, Mohamed Bidair, Steven Rosenberg, Paul Sieber, Adam Perzin, Susan Kalota, Amar Singh, Ralph Henderson, Jeffrey Wayne, Moben Mirza, Richard D’Anna, Fredrick Wolk, Osvaldo Padron, Kathryn Bylow, Jonathan Rubenstein, Benjamin Gartrell, Michael Schwartz, Kalpesh Patel, Ajit Maniam, Thomas Keane, Michael Goodman, Charles Bane, Michael Chung, Stephen Savage, Edward Uchio, Son Nguyen, William Aronson, Rakesh Khanna, Carlton Barnswell

Publikováno v: Circulation. 144(16)

Background: The relative cardiovascular safety of gonadotropin-releasing hormone (GnRH) antagonists compared with GnRH agonists in men with prostate cancer and known atherosclerotic cardiovascular disease remains controversial. Methods: In this inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9271ccb4eb75e7486635b0056df019
https://pubmed.ncbi.nlm.nih.gov/35312383

Germline Mutations in DNA Repair Genes in Patients With Metastatic Castration-resistant Prostate Cancer

Autor: Mark Hives, Klaudia Holeckova, Maria Skerenova, Katarina Baluchova, Ludovit Musak, Jan Kliment

Publikováno v: In Vivo

Background/aim The aim of this study was to analyse the genetic profiles of metastatic castration-resistant prostate cancer (mCRPC) by using next generation sequencing to identify variants with pathogenic potential in nine DNA repair genes - BRCA1, B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a399256b1ece251338b7feea593e91ac
https://pubmed.ncbi.nlm.nih.gov/32606146

PD37-02 PHASE III STUDY OF INTERMITTENT MONOTHERAPY VERSUS CONTINUOUS COMBINED ANDROGEN DEPRIVATION

Autor: Fernando Calais da Silva Junior, Fernando Calais da Silva Senior, Frederico Gonçalves, Jan Kliment, Américo Santos, Spiros Pastidis, Antonio Queimadelos, Chris Robertson

Publikováno v: Journal of Urology. 197

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3b6937b6155ac6ed5a31a326d780719
https://doi.org/10.1016/j.juro.2017.02.1564

Increased expression of neuronal nitric oxide synthase in bladder afferent cells in the lumbosacral dorsal root ganglia after chronic bladder outflow obstruction

Autor: Jeffrey B. Folsom, Adriana Moravčı́ková, Peter Zvara, Abbey Dattilio, Jan Kliment, Margaret A. Vizzard, Mark K. Plante

Publikováno v: Brain Research. 1002:35-42

Nitric oxide (NO), a neurotransmitter in autonomic reflex pathways, plays a role in functional neuroregulation of the lower urinary tract. Upregulation of the levels of neuronal nitric oxide synthase (nNOS), the enzyme system responsible for NO synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494dde38b54f0d37128816dc3b6ddddc
https://doi.org/10.1016/j.brainres.2003.12.016

Differential Expression of Bladder Neurotrophic Factor mRNA in Male and Female Rats After Bladder Outflow Obstruction

Autor: Margaret A. Vizzard, Mark K. Plante, Peter Zvara, Susan E. Malley, Brian H. Irwin, Anthony L DeRoss, Jan Kliment

Publikováno v: The Journal of Urology. :2682-2688

Purpose: We validated a male rat model of bladder outflow obstruction and compared the expression of bladder neurotrophic factor mRNA in male and female rats 6 weeks after bladder outlet obstruction.Materials and Methods: We examined the proximal ure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281a05e2ab433186d8abdb8987f588d2
https://doi.org/10.1097/00005392-200212000-00102