Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jan, Hojny"'
Autor:
Jana Soukupova, Barbora Stastna, Madiha Kanwal, Jan Hojny, Petra Zemankova, Marianna Borecka, Leona Cerna, Marta Cerna, Monika Cerna, Vaclava Curtisova, Tatana Dolezalova, Petra Duskova, Lenka Foretova, Ondrej Havranek, Klara Horackova, Milena Hovhannisyan, Lucie Hruskova, Stepan Chvojka, Marketa Janatova, Maria Janikova, Sandra Jelinkova, Pavel Just, Marta Kalousova, Petra Kleiblova, Marcela Kosarova, Monika Koudova, Jan Kral, Michaela Krausova, Vera Krutilkova, Eva Machackova, Katerina Matejkova, Renata Michalovska, Petr Nehasil, Barbora Nemcova, Jan Novotny, Matous Palek, Pavel Pesek, Marketa Safarikova, Ondrej Scheinost, Drahomira Springer, Lenka Stolarova, Viktor Stranecky, Ivan Subrt, Spiros Tavandzis, Eva Tureckova, Kamila Vesela, Zdenka Vlckova, Michal Vocka, Tomas Zima, Libor Macurek, Zdenek Kleibl, the CZECANCA consortium
Publikováno v:
Cancer Medicine, Vol 13, Iss 16, Pp n/a-n/a (2024)
Abstract Background Monoallelic germline pathogenic variants (GPVs) in five Fanconi anemia (FA) genes (BRCA1/FANCS, BRCA2/FANCD1, PALB2/FANCN, BRIP1/FANCJ, and RAD51C/FANCO) confer an increased risk of breast (BC) and/or ovarian (OC) cancer, but the
Externí odkaz:
https://doaj.org/article/a729e3f3d4b64ad89ec8fbe20e608bd3
Autor:
Jan Hojny, Romana Michalkova, Eva Krkavcova, Quang Hiep Bui, Michaela Bartu, Kristyna Nemejcova, Marta Kalousova, Petra Kleiblova, Pavel Dundr, Ivana Struzinska
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Hepatocyte nuclear factor-1-beta (HNF1B) is a transcription factor and putative biomarker of solid tumours. Recently, we have revealed a variety of HNF1B mRNA alternative splicing variants (ASVs) with unknown, but potentially regulatory, fun
Externí odkaz:
https://doaj.org/article/aec7ae3c623d4d48b67ca8c0a6068d56
Autor:
Lena Obeidova, Tomas Seeman, Filip Fencl, Kveta Blahova, Jan Hojny, Veronika Elisakova, Jana Reiterova, Jitka Stekrova
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0235071 (2020)
Cystic kidney diseases are a very heterogeneous group of chronic kidney diseases. The diagnosis is usually based on clinical and ultrasound characteristics and the final diagnosis is often difficult to be made. Next-generation sequencing (NGS) may he
Externí odkaz:
https://doaj.org/article/40e5750d5d9e4ed0b7b184e68fb455e3
Autor:
Jan, Hojny, Michaela, Bartu, Eva, Krkavcova, Kristyna, Nemejcova, Jan, Sevcik, David, Cibula, Vladimir, Fryba, Lenka, Plincelnerova, Pavel, Dundr, Ivana, Struzinska
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Hepatocyte nuclear factor-1-beta (HNF1B) is a transcription factor crucial for the development of several tissues, and a promising biomarker of certain solid tumours. Thus far, two HNF1B alternative splicing variants (ASVs) have been described, howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::65e1097a971991256ef414d914c77224
http://link.springer.com/article/10.1038/s41598-020-63733-x
http://link.springer.com/article/10.1038/s41598-020-63733-x
Autor:
Ondrej Havranek, Petra Kleiblova, Jan Hojny, Filip Lhota, Pavel Soucek, Marek Trneny, Zdenek Kleibl
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140819 (2015)
The checkpoint kinase 2 gene (CHEK2) codes for the CHK2 protein, an important mediator of the DNA damage response pathway. The CHEK2 gene has been recognized as a multi-cancer susceptibility gene; however, its role in non-Hodgkin lymphoma (NHL) remai
Externí odkaz:
https://doaj.org/article/51e8a334ff934ae4a76af9bc1815baf7
Autor:
Jan Hojny, Romana Michalkova, Eva Krkavcova, Quang Hiep Bui, Michaela Bartu, Kristyna Nemejcova, Marta Kalousova, Petra Kleiblova, Pavel Dundr, Ivana Struzinska
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Hepatocyte nuclear factor-1-beta (HNF1B) is a transcription factor and putative biomarker of solid tumours. Recently, we have revealed a variety of HNF1B mRNA alternative splicing variants (ASVs) with unknown, but potentially regulatory, functions. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d3b8d63564404fcab13df7a153e9c452
https://pubmed.ncbi.nlm.nih.gov/34997048
https://pubmed.ncbi.nlm.nih.gov/34997048
Autor:
Nikola, Hajkova, Jan, Hojny, Kristyna, Nemejcova, Pavel, Dundr, Jan, Ulrych, Katerina, Jirsova, Johana, Glezgova, Ivana, Ticha
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Scientific Reports
Scientific Reports
We performed comprehensive molecular analysis of five cases of metastasizing uveal malignant melanoma (UM) (fresh-frozen samples) with an NGS panel of 73 genes. A likely pathogenic germline TP53 mutation c.760A > G (p.I254V) was found in two tumor sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ce046f22724e9f6ef1ff2e400c76b2bd
http://link.springer.com/article/10.1038/s41598-018-26040-0
http://link.springer.com/article/10.1038/s41598-018-26040-0
Autor:
Marketa Janatova, Hana Hartmannová, Katerina Hodanova, Petra Kleiblova, Jan Hojny, Michal Vocka, Petra Zemankova, Filip Lhota, Ondrej Mestak, Viktor Stranecky, Jana Soukupova, Jan Sevcik, Zdenek Kleibl, D. Pavlista
Publikováno v:
Gene. 637:41-49
Alternative pre-mRNA splicing increases transcriptome plasticity by forming naturally-occurring alternative splicing variants (ASVs). Alterations of splicing processes, caused by DNA mutations, result in aberrant splicing and the formation of aberran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79cb59f73a27210fc4c1fb99738dc12
https://doi.org/10.1016/j.gene.2017.09.025
https://doi.org/10.1016/j.gene.2017.09.025
Autor:
Pavel Dundr, Ivana Tichá, Libor Macurek, Nikola Hájková, Zdenek Kleibl, Andra S. Martinikova, Eva Krkavcová, Romana Michálková, Petra Zemankova, Madiha Kanwal, Ondrej Kodet, Radek Jaksa, Jan Hojny, Kristyna Nemejcova, Miroslav Dura, Michaela Bartu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
The most common histological subtypes of cutaneous melanoma include superficial spreading and nodular melanoma. However, the spectrum of somatic mutations developed in those lesions and all potential druggable targets have not yet been fully elucidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd673da5902bf9bbe1abfbaf69cb724
https://doi.org/10.1038/s41598-019-53636-x
https://doi.org/10.1038/s41598-019-53636-x
Autor:
Lenka Stolarova, Libor Macurek, Aleš Panczak, Klara Lhotova, Marta Cerna, Stanislav Kmoch, Monika Burocziova, Jana Soukupova, Katerina Krizova, Jaroslav Kotlas, Viktor Stranecky, Petra Kleiblova, Kamila Burdova, Marketa Janatova, Jan Hojny, Michal Vocka, Petra Zemankova, Kamila Vesela, Jana Červenková, Jan Sevcik, Ondrej Havranek, Filip Lhota, Zdenek Kleibl, Eva Machackova, Spiros Tavandzis, Martina Zimovjanova, Lenka Foretova, Michaela Schneiderova, Marianna Borecka
Publikováno v:
International journal of cancer. 145(7)
Germline mutations in checkpoint kinase 2 (CHEK2), a multiple cancer-predisposing gene, increase breast cancer (BC) risk; however, risk estimates differ substantially in published studies. We analyzed germline CHEK2 variants in 1,928 high-risk Czech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e562181451ed0efce90310e998849c5
https://pubmed.ncbi.nlm.nih.gov/31050813
https://pubmed.ncbi.nlm.nih.gov/31050813