Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jan, Gursky"'
Autor:
Katarina Chroma, Zdenek Skrott, Jan Gursky, Jaroslav Bacovsky, Pavel Moudry, Tereza Buchtova, Martin Mistrik, Jiri Bartek
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-11 (2022)
Abstract Despite several approved therapeutic modalities, multiple myeloma (MM) remains an incurable blood malignancy and only a small fraction of patients achieves prolonged disease control. The common anti-MM treatment targets proteasome with speci
Externí odkaz:
https://doaj.org/article/3a153f215b3941189abf8b25abc8d0bc
Autor:
Katerina Smesny, Trtkova, Petra, Luzna, Denisa Weiser, Drozdkova, Katerina, Cizkova, Lucie, Janovska, Jan, Gursky, Dana, Prukova, Ivo, Frydrych, Marian, Hajduch, Jiri, Minarik
Publikováno v:
Molecular Medicine Reports. 26
Gene inactivation of the cyclin‑dependent kinase inhibitors p16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d805e09ef72e152fb2839bb9dde4d819
https://doi.org/10.3892/mmr.2022.12837
https://doi.org/10.3892/mmr.2022.12837
Autor:
Veronika Kropackova, Jan Gursky, Jana Balounova, Vladimir Korinek, Vladimir Divoky, Lucie Lanikova
Publikováno v:
Blood. 140:3858-3859
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb9718660f09b56d3cc989176d680cc1
https://doi.org/10.1182/blood-2022-165949
https://doi.org/10.1182/blood-2022-165949
Autor:
Pavla Koralkova, Nikola Niederlova, Iveta Hradilova, Jan Gursky, Barbora Cudova, Helena Urbankova, Eva Reznickova, Tomas Gucky, Denisa Myslivcova, Monika Belickova, Vladimir Krystof, Vladimir Divoky
Publikováno v:
Blood. 140:8823-8824
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d076a142500b20706648c8bf1313ab29
https://doi.org/10.1182/blood-2022-165022
https://doi.org/10.1182/blood-2022-165022
Autor:
Zdenek Kolar, Denisa Hrckova Drozdkova, Jiri Minarik, Katerina Smesny Trtkova, Ivo Uberall, Jan Gursky
Publikováno v:
Anticancer Research. 40:4979-4987
Background/aim Multiple myeloma is a highly heterogeneous disease of clonal plasma cells. Histone deacetylase (HDAC) inhibitors are promising anticancer drugs but their precise mechanisms of actions are not well understood. Materials and methods Cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eb3272f3b9ec4824eb07db2a2babe86
https://doi.org/10.21873/anticanres.14501
https://doi.org/10.21873/anticanres.14501
Autor:
Jiri Bartek, Martin Mistrik, Tereza Buchtova, Jan Gursky, Marian Hajduch, Zdenek Skrott, Dusana Majera
Publikováno v:
Oncogene. 38:6711-6722
Aldehyde dehydrogenase (ALDH) is a proposed biomarker and possible target to eradicate cancer stem cells. ALDH inhibition as a treatment approach is supported by anti-cancer effects of the alcohol-abuse drug disulfiram (DSF, Antabuse). Given that met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b141846c2884ea3d613f05237ad0295
https://doi.org/10.1038/s41388-019-0915-2
https://doi.org/10.1038/s41388-019-0915-2
Autor:
Sona Hubackova, Patrik Flodr, Jiri Bartek, Vladimir Divoky, Jan Gursky, Pavla Koralkova, Zdenek Hodny, Pavla Vyhlidalova, Jan Stetka, A Hlusi, Lucie Lanikova
Publikováno v:
Oncogene
Inflammatory and oncogenic signaling converge in disease evolution of BCR–ABL-negative myeloproliferative neoplasms, clonal hematopoietic stem cell disorders characterized by gain-of-function mutation in JAK2 kinase (JAK2V617F), with highest preval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f039a09c241387420425425f244a8e86
https://doi.org/10.1038/s41388-019-0813-7
https://doi.org/10.1038/s41388-019-0813-7
Autor:
Monika Horvathova, Lucie Lanikova, Jan Gursky, Vladimir Divoky, Pavla Koralkova, Katarina Kapralova, Dagmar Pospisilova, Ondrej Jahoda
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 24
International Journal of Molecular Sciences, Vol 21, Iss 9652, p 9652 (2020)
Volume 21
Issue 24
International Journal of Molecular Sciences, Vol 21, Iss 9652, p 9652 (2020)
Molecular pathophysiology of Diamond-Blackfan anemia (DBA) involves disrupted erythroid-lineage proliferation, differentiation and apoptosis
with the activation of p53 considered as a key component. Recently, oxidative stress was proposed to pla
with the activation of p53 considered as a key component. Recently, oxidative stress was proposed to pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c972f3053a9d7a3f945f8e366895f3
Autor:
Julie Liñan Velasquez, Pavla Vyhlidalova, Jiri Bartek, Jan Gursky, Renata Mojzikova, Jan Stetka, Vladimir Divoky, Lucia Vráblová
Publikováno v:
Cancers, Vol 12, Iss 903, p 903 (2020)
Cancers
Cancers
Inflammatory and oncogenic signaling, both known to challenge genome stability, are key drivers of BCR-ABL-positive chronic myeloid leukemia (CML) and JAK2 V617F-positive chronic myeloproliferative neoplasms (MPNs). Despite similarities in chronic in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1329ef56e757410de4150e311a8bb00
https://www.mdpi.com/2072-6694/12/4/903
https://www.mdpi.com/2072-6694/12/4/903
Autor:
Zdenek Hodny, Jirina Bartkova, Mariam Gachechiladze, Dana Simkova, Martin Mistrik, Dusana Majera, Jan Bouchal, Jana Steigerova, Karel Cwiertka, Jan Gursky, Gabriela Korinkova, Zdenek Skrott, Daniela Kurfürstová, Jiri Bartek
Publikováno v:
The Prostate. 79:352-362
Background Castration-resistant prostate cancer (PCa) represents a serious health challenge. Based on mechanistically-supported rationale we explored new therapeutic options based on clinically available drugs with anticancer effects, including inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff31228b5160f48d157463a8f1ae171
https://doi.org/10.1002/pros.23741
https://doi.org/10.1002/pros.23741