Zobrazeno 1 - 10 of 47 pro vyhledávání: '"Jan, Freijer"'
1
Oxycodone Effect on Pupil Constriction in Recreational Opioid Users: A Pharmacokinetic/Pharmacodynamic Meta-Analysis Approach
Autor: Michael Gautrois, Jens Rengelshausen, Anna Dari, Stefan Buller, Hans-Jürgen Stahlberg, Jan Freijer
Publikováno v: Clinical Pharmacokinetics. 60:785-794
Understanding the effect of oxycodone pharmacokinetics (PK) on µ-opioid receptor binding benefits from an integrated approach to compiling the results of multiple studies. The current pharmacokinetic/pharmacodynamic (PK/PD) model analysis brings tog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72cb809e15548137647c7aa231f0e1de
https://doi.org/10.1007/s40262-020-00980-1
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2
Population Pharmacokinetics of Tapentadol in Children from Birth to <18 Years Old
Autor: Thomas M. Tzschentke, Estelle Watson, Feras Khalil, Claudia Lefeber, Jan Freijer, Mariëlle Eerdekens, Siak Leng Choi
Publikováno v: Journal of Pain Research. 13:3107-3123
Objective The main aim of this analysis was to characterize the pharmacokinetics (PK) of tapentadol in pediatric patients from birth to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe1ea0e5875f96a9704d3c7b58c95c20
https://doi.org/10.2147/jpr.s269549
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3
Population pharmacokinetic modeling to facilitate dose selection of tapentadol in the pediatric population
Autor: Akash Khandelwal, John N. van den Anker, Mariëlle Eerdekens, Jan Freijer, Claudia Lefeber, Estelle Watson
Publikováno v: Journal of Pain Research. 12:2835-2850
Objective The main aim of this analysis was to characterize the pharmacokinetics (PK) of the strong analgesic tapentadol in 2-year-old to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7493295e5605738e73ab4bc3d6108cd
https://doi.org/10.2147/jpr.s208454
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5
Population Pharmacokinetic Model of THC Integrates Oral, Intravenous, and Pulmonary Dosing and Characterizes Short- and Long-term Pharmacokinetics
Autor: Jules A. A. C. Heuberger, Jan Freijer, Paul D. Morrison, Olubukayo-Opeyemi Oyetayo, Zheng Guan, Tim L. Beumer, Adam F. Cohen, Linda E. Klumpers, Joop M. A. van Gerven
Publikováno v: Clinical Pharmacokinetics, 54(2), 209-219
Δ(9)-Tetrahydrocannobinol (THC), the main psychoactive compound of Cannabis, is known to have a long terminal half-life. However, this characteristic is often ignored in pharmacokinetic (PK) studies of THC, which may affect the accuracy of predictio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf353647bd6db15435dea9952db7f269
https://doi.org/10.1007/s40262-014-0195-5
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6
Profiling the subjective effects of Δ9 -tetrahydrocannabinol using visual analogue scales
Autor: Daniël Kleinloog, Willem De Winter, Joop M. A. van Gerven, Jan Freijer, Frits Roozen
Publikováno v: International Journal of Methods in Psychiatric Research. 23:245-256
The subjective effects of cannabis and its main psychoactive component Δ9-tetrahydrocannabinol (THC) have played an important part in determining the therapeutic potential of cannabinoid agonists and antagonists. The effects mainly consist of feelin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d88a8645a8d64c51345f4d8dda374f3
https://doi.org/10.1002/mpr.1424
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7
Pharmacokinetics and Pharmacodynamics of Orally Administered Clonidine: A Model-Based Approach
Autor: Jacobus Burggraaf, Rám N. Sukhai, Boudewijn Bakker, Adam F. Cohen, H M Reeser, P Hu, Erica S. Klaassen, Richard H. Klein, B E P B Ballieux, Wilma Oostdijk, Ricardo Alvarez-Jimenez, J.M. Wit, Jan Freijer
Publikováno v: Hormone Research in Paediatrics, 79(5), 300-309
Klein, R H, Alvarez-Jimenez, R, Sukhai, R N, Oostdijk, W, Bakker, B, Reeser, H M, Ballieux, B E P B, Hu, P, Klaassen, E S, Freijer, J, Burggraaf, J, Cohen, A F & Wit, J M 2013, ' Pharmacokinetics and pharmacodynamics of orally administered clonidine : A model-based approach ', Hormone Research in Paediatrics, vol. 79, no. 5, pp. 300-309 . https://doi.org/10.1159/000350819
Hormone Research in Paediatrics, 79(5), 300-309. S. Karger AG
Background/Aims: The oral clonidine test is a diagnostic procedure performed in children with suspected growth hormone (GH) deficiency. It is associated with untoward effects, including bradycardia, hypotension and sedation. Serum clonidine levels ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ee96142c04000c934356ab6b152d5e
https://doi.org/10.1159/000350819
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8
Monitoring Prednisolone and Prednisone in Saliva: a population pharmacokinetic approach in healthy volunteers
Autor: Joana E. Kist-van Holthe, Zheng Guan, Nynke Teeninga, Teun van Gelder, Mariëtte T. Ackermans, An F. C. Ruiter, Jan Freijer, Jeroen Nauta
Publikováno v: Therapeutic Drug Monitoring, 34(4), 485-492. Lippincott Williams & Wilkins
Therapeutic Drug Monitoring, 35(4), 485-492. Lippincott Williams and Wilkins
Therapeutic drug monitoring, 35(4), 485-492. Lippincott Williams and Wilkins
Teeninga, N, Guan, Z, Freijer, J, Ruiter, A F C, Ackermans, M T, Kist-van Holthe, J E, van Gelder, T & Nauta, J 2013, ' Monitoring Prednisolone and Prednisone in Saliva: A Population Pharmacokinetic Approach in Healthy Volunteers ', Therapeutic Drug Monitoring, vol. 35, no. 4, pp. 485-492 . https://doi.org/10.1097/FTD.0b013e3182899ea2
BACKGROUND: Prednisolone (PLN) is a widely used corticosteroid in a variety of immune-mediated diseases. Treatment regimes generally consist of empirically derived treatment doses, whereas therapeutic response among patients is highly variable. Drug
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1fdf575ffb905f4e506c4d76856dd3
https://hdl.handle.net/1765/41265
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9
Novel Δ9-tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects
Autor: Astrid Lipplaa, Jan Freijer, Tim L. Beumer, Lennard B. Karger, Joop M. A. van Gerven, Johan G. C. van Hasselt, Marieke L. de Kam, Linda E. Klumpers, H. Daniël Kleinloog
Publikováno v: British Journal of Clinical Pharmacology. 74:42-53
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Cannabis based medicines are registered as a treatment for various indications, such as pain and spasms in multiple sclerosis (MS) patients, and anorexia and nausea in patients with HIV or receiving cancer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e93105508c0363dcc91541abf917665b
https://doi.org/10.1111/j.1365-2125.2012.04164.x
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10
Pharmacokinetic-pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex
Autor: Jan Freijer, Marian Geldof, Meindert Danhof, Xavier Langlois, L van Beijsterveldt
Publikováno v: British Journal of Pharmacology. 154:1369-1378
Background and purpose: The pharmacokinetic–pharmacodynamic (PK–PD) correlation of fluvoxamine 5-HT transporter (SERT) occupancy was determined in rat frontal cortex ex vivo. Experimental approach: Rats (n=47) with permanent arterial and venous c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::baf6fe453a30209b0498cbdf483d4383
https://doi.org/10.1038/bjp.2008.179
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