Zobrazeno 1 - 10
of 380
pro vyhledávání: '"Jan, Fiedler"'
Autor:
Kevin Schmidt, Arne Schmidt, Sonja Groß, Annette Just, Angelika Pfanne, Maximilian Fuchs, Maria Jordan, Elisa Mohr, Andreas Pich, Jan Fiedler, Thomas Thum
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Beneficial effects of sodium glucose co-transporter 2 inhibitors (SGLT2is) in cardiovascular diseases have been extensively reported leading to the inclusion of these drugs in the treatment guidelines for heart failure. However, molecular ac
Externí odkaz:
https://doaj.org/article/0e2917f31446424496133fadf37d1b29
Autor:
Alice Barbero, Laura Rotundo, Chiara Reviglio, Roberto Gobetto, Romana Sokolova, Jan Fiedler, Carlo Nervi
Publikováno v:
Molecules, Vol 28, Iss 22, p 7535 (2023)
This study aimed to demonstrate the behavior of different complexes using IR spectroelectrochemistry (SEC), a technique that combines IR spectroscopy with electrochemistry. Four different Mn and Re catalysts for electrochemical CO2 reduction were stu
Externí odkaz:
https://doaj.org/article/4ac9ba7eb58f480bacc3a489d239c1cb
Autor:
Britta Stapel, Ke Xiao, Nataliya Gorinski, Kevin Schmidt, Angelika Pfanne, Jan Fiedler, Imke Richter, Anna-Lena Vollbrecht, Thomas Thum, Kai G. Kahl, Evgeni Ponimaskin
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
ObjectiveMajor depressive disorder (MDD) constitutes a main risk factor for suicide. Suicide risk in psychiatric patients is primarily determined by often unreliable, self-reported information. We assessed serum levels of three microRNAs (miRNAs), pr
Externí odkaz:
https://doaj.org/article/f419f568ff3c48a281d74bb27711ec03
Autor:
Stevan D. Stojanović, Maximilian Fuchs, Chunguang Liang, Kevin Schmidt, Ke Xiao, Annette Just, Angelika Pfanne, Andreas Pich, Gregor Warnecke, Peter Braubach, Christina Petzold, Danny Jonigk, Jörg H. W. Distler, Jan Fiedler, Thomas Thum, Meik Kunz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The family of RNA-binding proteins (RBP) functions as a crucial regulator of multiple biological processes and diseases. However, RBP function in the clinical setting of idiopathic pulmonary fibrosis (IPF) is still unknown. We developed a pr
Externí odkaz:
https://doaj.org/article/757334abd2ab4df69064526720aa8b80
Autor:
Arne Schmidt, Maximilian Fuchs, Stevan D. Stojanović, Chunguang Liang, Kevin Schmidt, Mira Jung, Ke Xiao, Jan Weusthoff, Annette Just, Angelika Pfanne, Jörg H. W. Distler, Thomas Dandekar, Jan Fiedler, Thomas Thum, Meik Kunz
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundConstant supply of oxygen is crucial for multicellular tissue homeostasis and energy metabolism in cardiac tissue. As a first response to acute hypoxia, endothelial cells (ECs) promote recruitment and adherence of immune cells to the dysbal
Externí odkaz:
https://doaj.org/article/d9a651f1db284f5493baf7e4bc10f6af
Autor:
Kristina Sonnenschein, Jan Fiedler, David de Gonzalo-Calvo, Ke Xiao, Angelika Pfanne, Annette Just, Carolin Zwadlo, Samira Soltani, Udo Bavendiek, Theresia Kraft, Cristobal Dos Remedios, Serghei Cebotari, Johann Bauersachs, Thomas Thum
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Hypertrophic cardiomyopathy (HCM) is one of the most common hereditary heart diseases and can be classified into an obstructive (HOCM) and non-obstructive (HNCM) form. Major characteristics for HCM are the hypertrophy of cardiomyocytes and d
Externí odkaz:
https://doaj.org/article/512e2ec0033c4485af4d7813594d8685
Autor:
Ariana Foinquinos, Sandor Batkai, Celina Genschel, Janika Viereck, Steffen Rump, Mariann Gyöngyösi, Denise Traxler, Martin Riesenhuber, Andreas Spannbauer, Dominika Lukovic, Natalie Weber, Katrin Zlabinger, Ena Hašimbegović, Johannes Winkler, Jan Fiedler, Seema Dangwal, Martin Fischer, Jeanne de la Roche, Daniel Wojciechowski, Theresia Kraft, Rita Garamvölgyi, Sonja Neitzel, Shambhabi Chatterjee, Xiaoke Yin, Christian Bär, Manuel Mayr, Ke Xiao, Thomas Thum
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
miR-132 was shown to drive pathological cardiac remodeling, a hallmark of heart failure. Here, the authors show that an antisense inhibitor of miR-132 has favourable pharmacokinetics, safety-tolerability and preclinical efficacy in mouse and porcine
Externí odkaz:
https://doaj.org/article/33579ddb7f504de8ad9792e4fd12c4d2
Autor:
Franziska Kenneweg, Claudia Bang, Ke Xiao, Chantal M. Boulanger, Xavier Loyer, Stephane Mazlan, Blanche Schroen, Steffie Hermans-Beijnsberger, Ariana Foinquinos, Marc N. Hirt, Thomas Eschenhagen, Sandra Funcke, Stevan Stojanovic, Celina Genschel, Katharina Schimmel, Annette Just, Angelika Pfanne, Kristian Scherf, Susann Dehmel, Stella M. Raemon-Buettner, Jan Fiedler, Thomas Thum
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 363-374 (2019)
Long non-coding RNAs (lncRNAs) have potential as novel therapeutic targets in cardiovascular diseases, but detailed information about the intercellular lncRNA shuttling mechanisms in the heart is lacking. Here, we report an important novel crosstalk
Externí odkaz:
https://doaj.org/article/082462a5ca7046e4a3a1e853a2b8ca0e
Autor:
Nataliya Gorinski, Monika Bijata, Sonal Prasad, Alexander Wirth, Dalia Abdel Galil, Andre Zeug, Daria Bazovkina, Elena Kondaurova, Elizabeth Kulikova, Tatiana Ilchibaeva, Monika Zareba-Koziol, Francesco Papaleo, Diego Scheggia, Gaga Kochlamazashvili, Alexander Dityatev, Ian Smyth, Adam Krzystyniak, Jakub Wlodarczyk, Diethelm W. Richter, Tatyana Strekalova, Stephan Sigrist, Claudia Bang, Lisa Hobuß, Jan Fiedler, Thomas Thum, Vladimir S. Naumenko, Ghanshyam Pandey, Evgeni Ponimaskin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implica
Externí odkaz:
https://doaj.org/article/b7ca995a09f14264a865413198bdb889
Autor:
Beate Vajen, Rahul Bhowmick, Luisa Greiwe, Vera Schäffer, Marlies Eilers, Thea Reinkens, Amelie Stalke, Gunnar Schmidt, Jan Fiedler, Thomas Thum, David S. DeLuca, Ian D. Hickson, Brigitte Schlegelberger, Thomas Illig, Britta Skawran
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5131 (2022)
Chromosomal instability (CIN) can be a driver of tumorigenesis but is also a promising therapeutic target for cancer associated with poor prognosis such as triple negative breast cancer (TNBC). The treatment of TNBC cells with defects in DNA repair g
Externí odkaz:
https://doaj.org/article/4704b2949fa74e5797bf9e986e220ff2