Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jan, Blid"'
Publikováno v:
The Journal of Organic Chemistry. 72:1294-1300
The first asymmetric [2,3]-sigmatropic rearrangement of achiral allylic amines has been realized by quaternization of the amines with an enantiomerically pure diazaborolidine and subsequent treatment with Et3N. The resultant homoallylic amines were o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17df645995311fb8947bdb9e656a0fc
https://doi.org/10.1021/jo062178v
https://doi.org/10.1021/jo062178v
Autor:
Jan Blid, Peter Somfai
Publikováno v:
Tetrahedron Letters. 44:3159-3162
An investigation of the Lewis acid mediated [2,3]-sigmatropic rearrangement of allylic ammonium ylides has been conducted by employing various bases and boron Lewis acids. Using BBr3 together with ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8c3f236b02d56f3328e2fa3914324d
https://doi.org/10.1016/s0040-4039(03)00510-0
https://doi.org/10.1016/s0040-4039(03)00510-0
Autor:
Jenny Viklund, Ylva Gravenfors, Fredrik Jeppsson, Anders E. G. Lindgren, Anh Johansson, Jonas Malmström, Jan Blid, Karin J. Sterky, Annika Kers, Rickard Forsblom, Rikard Emond, Johanna Fälting, Tobias Ginman, Fredrik Rahm, Patrik Johansson, Margareta Bergh, Fredrik Lake, Fernando Sehgelmeble
Publikováno v:
Journal of medicinal chemistry. 56(11)
By use of iterative design aided by predictive models for target affinity, brain permeability, and hERG activity, novel and diverse compounds based on cyclic amidine and guanidine cores were synthesized with the goal of finding BACE-1 inhibitors as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28939a6aa8f37799fef11079a09af60e
https://pubmed.ncbi.nlm.nih.gov/23126626
https://pubmed.ncbi.nlm.nih.gov/23126626
Autor:
Ylva, Gravenfors, Jenny, Viklund, Jan, Blid, Tobias, Ginman, Sofia, Karlström, Jacob, Kihlström, Karin, Kolmodin, Johan, Lindström, Stefan, von Berg, Fredrik, von Kieseritzky, Krisztian, Bogar, Can, Slivo, Britt-Marie, Swahn, Lise-Lotte, Olsson, Patrik, Johansson, Susanna, Eketjäll, Johanna, Fälting, Fredrik, Jeppsson, Kia, Strömberg, Juliette, Janson, Fredrik, Rahm
Publikováno v:
Journal of medicinal chemistry. 55(21)
Amino-2H-imidazoles are described as a new class of BACE-1 inhibitors for the treatment of Alzheimer’s disease. Synthetic methods, crystal structures, and structure–activity relationships for target activity, permeability, and hERG activity are r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e0ec2c24a4566dacbf31db9c6264bc
https://pubmed.ncbi.nlm.nih.gov/23017051
https://pubmed.ncbi.nlm.nih.gov/23017051
Autor:
Johan Bylund, Daniel Sohn, Jan Blid, Yevgeni Besidski, Ismet Dorange, Mats Svensson, Rickard Forsblom, Ylva Gravenfors, Istvan Macsari
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(22)
A novel indolizine class of compounds was identified as TRPV1 antagonist from an HTS campaign. However, this indolizine class proved to be unstable and reacted readily with glutathione when exposed to light and oxygen. Reactivity was reduced by the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54149edab698d5a6814f182127291414
https://pubmed.ncbi.nlm.nih.gov/23058884
https://pubmed.ncbi.nlm.nih.gov/23058884
Publikováno v:
ChemInform. 35
Boron trifluoride and BBr(3) mediated [2,3]-sigmatropic rearrangements of allylic alpha-amino amides have been developed affording secondary amines in good yields. (E)-Crotyl and (E)-cinnamyl alpha-amino amides 2b and 2c exhibit excellent syn-diaster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82faf532cf06d88952687bbb3a43172
https://doi.org/10.1002/chin.200434068
https://doi.org/10.1002/chin.200434068
Publikováno v:
Journal of the American Chemical Society. 127:9352-9353
An asymmetric Lewis acid-mediated [2,3]-sigmatropic rearrangement of allylic amines has been developed, affording the corresponding homoallylic amines in good yield and excellent enantioselectivities. The rearrangement proceeds by complexation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d885d35edf6ee9b56f28272de6e3cf46
https://doi.org/10.1021/ja0510562
https://doi.org/10.1021/ja0510562
Autor:
Jacob Kihlström, Johan Lindström, Fredrik Jeppsson, Johanna Fälting, Can Slivo, Tobias Ginman, Susanna Eketjäll, Jenny Viklund, Fredrik Rahm, Patrik Johansson, Jan Blid, Britt-Marie Swahn, Juliette Janson, Karin Kolmodin, Ylva Gravenfors, Krisztián Bogár, Stefan von Berg, Lise-Lotte Olsson, Kia Strömberg, Fredrik von Kieseritzky, Sofia Karlström
Publikováno v:
Journal of Medicinal Chemistry. 55:10316-10316
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e1081d06fc452e5b5f2bc8f7c0e42dc
https://doi.org/10.1021/jm301629c
https://doi.org/10.1021/jm301629c
Publikováno v:
Synthetic Metals. 120:1061-1062
1,2-ethanedisulfenyl chloride 1 has been utilized as a electrophilic reagent for the preparation of dihydro-1,4-dithiino substituted aromatics. The title reagent reacts with activated aromatics to give several new heterocyclic systems in modest yield
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e43e045ba0f81ad7d55a07c0bef04159
https://doi.org/10.1016/s0379-6779(00)01227-3
https://doi.org/10.1016/s0379-6779(00)01227-3