The BioHybrid Assay: A Novel Method for Determining Calcification Propensity.

Autor: Jaminon AMG; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands., Akbulut AC; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands., Rapp N; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands., Reutelingsperger CP; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands., Schurgers LJ; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands. l.schurgers@maastrichtuniversity.nl.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2664, pp. 317-331.

Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification.

Autor: Skenteris NT; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden.; Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Department of Biochemistry and CARIM, School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands., Seime T; Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden., Witasp A; Division of Renal Medicine, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute, Stockholm, Sweden., Karlöf E; Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden., Wasilewski GB; Department of Biochemistry and CARIM, School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands.; Nattopharma ASA, Oslo, Norway., Heuschkel MA; Department of Biochemistry and CARIM, School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands.; Department of Internal Medicine I-Cardiology, Medical Faculty, RWTH Aachen University, Aachen, Germany., Jaminon AMG; Department of Biochemistry and CARIM, School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands., Oduor L; Department of Clinical Sciences Malmö and Cardiology, Skåne University Hospital, Lund University, Lund, Sweden., Dzhanaev R; Department of Biochemistry and CARIM, School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands.; Biointerface Group, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany., Kronqvist M; Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden., Lengquist M; Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden., Peeters FECM; Department of Cardiology and CARIM, School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, Netherlands., Söderberg M; Cardiovascular, Renal and Metabolism Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Hultgren R; Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden., Roy J; Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden., Maegdefessel L; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden.; Klinikum rechts der Isar, Department for Vascular and Endovascular Surgery, Technical University Munich, Munich, Germany., Arnardottir H; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden., Bengtsson E; Department of Clinical Sciences Malmö and Cardiology, Skåne University Hospital, Lund University, Lund, Sweden., Goncalves I; Department of Clinical Sciences Malmö and Cardiology, Skåne University Hospital, Lund University, Lund, Sweden., Quertermous T; Department of Cardiovascular Medicine, University of Stanford, Stanford, California, USA., Goettsch C; Department of Internal Medicine I-Cardiology, Medical Faculty, RWTH Aachen University, Aachen, Germany., Stenvinkel P; Division of Renal Medicine, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute, Stockholm, Sweden., Schurgers LJ; Department of Biochemistry and CARIM, School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Matic L; Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2022 Feb; Vol. 12 (2), pp. e682.

Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity.

Autor: Jaminon AMG; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands., Akbulut AC; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands., Rapp N; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands., Kramann R; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, 52074 Aachen, Germany.; Department of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, 52074 Aachen, Germany., Biessen EAL; Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, 6229 HX Maastricht, The Netherlands.; Institute for Molecular Cardiovascular Research (IMCAR), Universitätsklinikum Aachen, 52074 Aachen, Germany., Temmerman L; Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, 6229 HX Maastricht, The Netherlands., Mees B; Department of Vascular Surgery, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands., Brandenburg V; Department of Cardiology, Rhein-Maas-Klinikum Würselen, 52146 Würselen, Germany., Dzhanaev R; Helmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University, 52074 Aachen, Germany., Jahnen-Dechent W; Helmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University, 52074 Aachen, Germany., Floege J; Department of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, 52074 Aachen, Germany., Uitto J; Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA., Reutelingsperger CP; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands., Schurgers LJ; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands.; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, 52074 Aachen, Germany.; Institute for Molecular Cardiovascular Research (IMCAR), Universitätsklinikum Aachen, 52074 Aachen, Germany.

Publikováno v: Cells [Cells] 2021 Aug 16; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 16.

Functional vitamin K insufficiency, vascular calcification and mortality in advanced chronic kidney disease: A cohort study.

Autor: Dai L; Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden., Li L; Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.; Department of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China., Erlandsson H; Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden., Jaminon AMG; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Qureshi AR; Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden., Ripsweden J; Division of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.; Department of Radiology, Karolinska University Hospital, Huddinge, Stockholm, Sweden., Brismar TB; Division of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.; Department of Radiology, Karolinska University Hospital, Huddinge, Stockholm, Sweden., Witasp A; Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden., Heimbürger O; Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden., Jørgensen HS; Department of Microbiology Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven-University of Leuven, Leuven, Belgium., Barany P; Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden., Lindholm B; Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden., Evenepoel P; Department of Microbiology Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven-University of Leuven, Leuven, Belgium.; Department of Nephrology, University Hospitals Leuven, Leuven, Belgium., Schurgers LJ; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Stenvinkel P; Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Publikováno v: PloS one [PLoS One] 2021 Feb 24; Vol. 16 (2), pp. e0247623. Date of Electronic Publication: 2021 Feb 24 (Print Publication: 2021).

Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice.

Autor: Posthuma JJ; Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.; Department of Surgery, Amsterdam University Medical Center, Location AMC, Amsterdam, The Netherlands., Posma JJN; Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands., van Oerle R; Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands., Leenders P; Department of Pharmacology-Toxicology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., van Gorp RH; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Jaminon AMG; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Mackman N; Thrombosis and Hemostasis Program, Division of Hematology and Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Heitmeier S; Research & Development,Pharmaceuticals, Bayer AG, Wuppertal, Germany., Schurgers LJ; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Ten Cate H; Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands., Spronk HMH; Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands. henri.spronk@maastrichtuniversity.nl.

Publikováno v: Scientific reports [Sci Rep] 2019 Mar 07; Vol. 9 (1), pp. 3909. Date of Electronic Publication: 2019 Mar 07.