Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jamin D Boggs"'
Autor:
Pascal Bonaventure, Leah Aluisio, James Shoblock, Jamin D Boggs, Ian C Fraser, Brian Lord, Timothy W Lovenberg, Ruggero Galici
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20210 (2011)
The role of 5-HT₇ receptor has been demonstrated in various animal models of mood disorders; however its function in cognition remains largely speculative. This study evaluates the effects of SB-269970, a selective 5-HT₇ antagonist, in a translat
Externí odkaz:
https://doaj.org/article/625bbaacd439475e85ab2b3777ebb702
Autor:
James A. Palmer, Natalie Welty, James R. Shoblock, Leah Aluisio, Nicholas I. Carruthers, Ian Fraser, Pascal Bonaventure, S. Timothy Motley, Timothy W. Lovenberg, Ruggero Galici, Kirsten L. Morton, Jamin D. Boggs
Publikováno v:
Psychopharmacology. 215:191-203
Orexin-1 receptor antagonists have been shown to block the reinforcing effects of drugs of abuse and food. However, whether blockade of orexin-2 receptor has similar effects has not been determined. We have recently described the in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfa317e6424220ebfe6fb5bc1300091
https://doi.org/10.1007/s00213-010-2127-x
https://doi.org/10.1007/s00213-010-2127-x
Autor:
Ruggero Galici, Amir H. Rezvani, Timothy W. Lovenberg, Leah Aluisio, Edward D. Levin, Natalie Welty, Pascal Bonaventure, Christine Dugovic, Jamin D. Boggs, S. Timothy Motley, Michael A. Letavic, Nicholas I. Carruthers, James R. Shoblock, Brian Lord, Ian Fraser
Publikováno v:
Psychopharmacology. 214:829-841
A few recent studies suggest that brain histamine levels and signaling via H(3) receptors play an important role in modulation of alcohol stimulation and reward in rodents.The present study characterized the effects of a novel, selective, and brain p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10df79c01db76937c8b84ea0062099d2
https://doi.org/10.1007/s00213-010-2092-4
https://doi.org/10.1007/s00213-010-2092-4
Autor:
Brett D. Allison, Alice Lee-Dutra, Jamin D. Boggs, Brian Lord, Alejandro Santillan, Anita M. Everson, Kelly J. McClure, Timothy W. Lovenberg, Kirsten L. Morton, Cheryl A. Grice, Michael A. Letavic, Diane Nepomuceno, Nicholas I. Carruthers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6226-6230
Previous research on histamine H(3) antagonists has led to the development of a pharmacophore model consisting of a central phenyl core flanked by two alkylamine groups. Recent investigation of the replacement of the central phenyl core with heteroar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1b948e9b1e0331b19453a6508ea02f
https://doi.org/10.1016/j.bmcl.2010.08.103
https://doi.org/10.1016/j.bmcl.2010.08.103
Autor:
Timothy W. Lovenberg, Lisa Dvorak, Jamin D. Boggs, Brian Lord, Curt Mazur, Swanson Devin M, Pascal Bonaventure, Richard Apodaca, Chandra R. Shah, Kirsten L. Morton, Ann J. Barbier, Mark A. Feinstein, Sandy J. Wilson, Nicholas I. Carruthers, Wei Xiao
Publikováno v:
European Journal of Medicinal Chemistry. 44:4413-4425
A series of small molecules consisting of a heterocyclic core flanked by two basic functionalities were synthesized and screened for in vitro affinity at the human histamine H 3 receptor (hH 3 R). Nine of the twenty-eight compounds tested were found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191de461163ea927780543b36eb2f631
https://doi.org/10.1016/j.ejmech.2009.06.007
https://doi.org/10.1016/j.ejmech.2009.06.007
Autor:
Lisa Dvorak, Curt A. Dvorak, Curt Mazur, Kiev S. Ly, Michael Bogenstaetter, Jill A. Jablonowski, Brian Lord, Timothy W. Lovenberg, Jamin D. Boggs, Kirsten L. Miller, Nicholas I. Carruthers, Sandy J. Wilson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:903-907
A novel series of imidazole containing histamine H3 receptor ligands were investigated and found to be potent functional antagonists. After improving the stability of these molecules towards liver microsomes, these compounds were found to have no app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c13fe402ebda266c7b30dd1d778341d
https://doi.org/10.1016/j.bmcl.2008.11.114
https://doi.org/10.1016/j.bmcl.2008.11.114
Autor:
Jamin D. Boggs, Brian Lord, Bruce E. Maryanoff, Lisa Dvorak, Leah Aluisio, Pascal Bonaventure, Timothy W. Lovenberg, Michael A. Letavic, Nicholas I. Carruthers, Sandy J. Wilson, Ian Fraser, Ann J. Barbier
Publikováno v:
European Journal of Pharmacology. 587:141-146
Triple reuptake inhibitors, which block the serotonin transporter (SERT), norepinephrine transporter (NET) and dopamine transporter (DAT) in the central nervous system have been described as therapeutic alternatives for classical selective serotonin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6545fa30b1a6c4f407d17ad6e16ec6fd
https://doi.org/10.1016/j.ejphar.2008.04.008
https://doi.org/10.1016/j.ejphar.2008.04.008
Autor:
Xiaohui Jiang, Kirsten L. Miller, Emily M. Stocking, Lisa Dvorak, Nicholas I. Carruthers, Jamin D. Boggs, Kiev S. Ly, Sandy J. Wilson, Brian Lord, Michael A. Letavic, Diane Nepomuceno, Jennifer M. Miller, John M. Keith, Pascal Bonaventure, Ann J. Barbier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:39-43
The synthesis and biological activity of a new series of piperazine and diazepane amides is described. The new compounds are high affinity histamine H 3 ligands and serotonin reuptake inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe46c5609bba379abad9abe531ad4b8
https://doi.org/10.1016/j.bmcl.2007.11.016
https://doi.org/10.1016/j.bmcl.2007.11.016
Autor:
Sandy J. Wilson, Timothy W. Lovenberg, Ann J. Barbier, Leah Aluisio, Leslie A. Gomez, John M. Keith, Jamin D. Boggs, Nicholas I. Carruthers, Brian Lord, Curt Mazur
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4374-4377
A series of novel and potent 6-heteroaryl-pyrrolidino-tetrahydroisoquinolines with dual histamine H(3) antagonist/serotonin transporter inhibitor activity is described. In vitro and in vivo data are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2d2af4ed1e8edaac7da1dd4b66dd0a
https://doi.org/10.1016/j.bmcl.2007.03.043
https://doi.org/10.1016/j.bmcl.2007.03.043
Autor:
Kiev S. Ly, John M. Keith, Carsten Schubert, Jiejun Wu, Michael A. Letavic, Ann J. Barbier, Sandy J. Wilson, Marta C. Abad, Brian Lord, Heather McAllister, Kirsten L. Miller, Nicholas I. Carruthers, Emily M. Stocking, D.J. Tognarelli, Jill A. Jablonowski, Timothy W. Lovenberg, Leslie A. Gomez, Pascal Bonaventure, Jamin D. Boggs, Jennifer M. Miller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1047-1051
A series of novel 4-aryl-1,2,3,4-tetrahydroisoquinoline-based histamine H(3) ligands that also have serotonin reuptake transporter inhibitor activity is described. The synthesis, in vitro biological data, and select pharmacokinetic data for these nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18387593a9ce978641ff4e2bca48f8a
https://doi.org/10.1016/j.bmcl.2006.11.036
https://doi.org/10.1016/j.bmcl.2006.11.036