Targeting Pf CLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment.

Autor: Brettell SB; School of Chemistry, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Janha O; Centre for Translational Pharmacology, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Begen A; KelticPharma Therapeutics, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Cann G; KelticPharma Therapeutics, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Sharma S; KelticPharma Therapeutics, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Olaniyan N; Centre for Translational Pharmacology, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Yelland T; Evotec (U.K.) Ltd, 95 Park Drive, Milton Park, Abingdon, Oxfordshire OX14 4RY, U.K., Hole AJ; Evotec (U.K.) Ltd, 95 Park Drive, Milton Park, Abingdon, Oxfordshire OX14 4RY, U.K., Alam B; Evotec (U.K.) Ltd, 95 Park Drive, Milton Park, Abingdon, Oxfordshire OX14 4RY, U.K., Mayville E; Department of Microbiology& Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Medical Centre, New York, New York 10032, United States., Gillespie R; School of Chemistry, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Capper M; School of Chemistry, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Fidock DA; Department of Microbiology& Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Medical Centre, New York, New York 10032, United States., Milligan G; Centre for Translational Pharmacology, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Clarke DJ; EaSTCHEM School of Chemistry, University of Edinburgh, Joseph Black Building, David, Brewster Road, Edinburgh EH9 3FJ, U.K., Tobin AB; Centre for Translational Pharmacology, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Jamieson AG; School of Chemistry, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Nov 14; Vol. 67 (21), pp. 18895-18910. Date of Electronic Publication: 2024 Oct 23.

Development of Bifunctional, Raman Active Diyne-Girder Stapled α-Helical Peptides.

Autor: Morgan DC; School of Chemistry, Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow, G11 6EW, UK., McDougall L; School of Chemistry, Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow, G11 6EW, UK., Knuhtsen A; School of Chemistry, Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow, G11 6EW, UK., Jamieson AG; School of Chemistry, Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow, G11 6EW, UK.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Jul 20; Vol. 29 (41), pp. e202300855. Date of Electronic Publication: 2023 Jun 13.

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Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists.

Autor: Mahindra A; School of Chemistry, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ, U.K., Jenkins L; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, University of Glasgow, Davidson Building, Glasgow G12 8QQ, U.K., Marsango S; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, University of Glasgow, Davidson Building, Glasgow G12 8QQ, U.K., Huggett M; BioAscent Discovery Ltd., Newhouse, Lanarkshire ML1 5UH, U.K.; European Screening Centre, University of Dundee, Newhouse, Lanarkshire ML1 5UH, U.K., Huggett M; BioAscent Discovery Ltd., Newhouse, Lanarkshire ML1 5UH, U.K.; European Screening Centre, University of Dundee, Newhouse, Lanarkshire ML1 5UH, U.K., Robinson L; BioAscent Discovery Ltd., Newhouse, Lanarkshire ML1 5UH, U.K.; European Screening Centre, University of Dundee, Newhouse, Lanarkshire ML1 5UH, U.K., Gillespie J; BioAscent Discovery Ltd., Newhouse, Lanarkshire ML1 5UH, U.K.; European Screening Centre, University of Dundee, Newhouse, Lanarkshire ML1 5UH, U.K., Rajamanickam M; BioAscent Discovery Ltd., Newhouse, Lanarkshire ML1 5UH, U.K.; European Screening Centre, University of Dundee, Newhouse, Lanarkshire ML1 5UH, U.K., Morrison A; BioAscent Discovery Ltd., Newhouse, Lanarkshire ML1 5UH, U.K.; European Screening Centre, University of Dundee, Newhouse, Lanarkshire ML1 5UH, U.K., McElroy S; BioAscent Discovery Ltd., Newhouse, Lanarkshire ML1 5UH, U.K.; European Screening Centre, University of Dundee, Newhouse, Lanarkshire ML1 5UH, U.K., Tikhonova IG; School of Pharmacy, Medical Biology Centre, Queen's University Belfast, Belfast BT9 7BL, U.K., Milligan G; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, University of Glasgow, Davidson Building, Glasgow G12 8QQ, U.K., Jamieson AG; School of Chemistry, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ, U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Aug 25; Vol. 65 (16), pp. 11270-11290. Date of Electronic Publication: 2022 Aug 10.

Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction.

Autor: Mahindra A; School of Chemistry, University of Glasgow, Glasgow, United Kingdom., Tejeda G; Institute of Molecular Cell & Systems Biology, School of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Rossi M; Institute of Molecular Cell & Systems Biology, School of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Janha O; Institute of Molecular Cell & Systems Biology, School of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Herbert I; MRC Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom., Morris C; School of Chemistry, University of Glasgow, Glasgow, United Kingdom., Morgan DC; School of Chemistry, University of Glasgow, Glasgow, United Kingdom., Beattie W; Institute of Cardiovascular and Medical Sciences, Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Montezano AC; Institute of Cardiovascular and Medical Sciences, Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Hudson B; Institute of Molecular Cell & Systems Biology, School of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Tobin AB; Institute of Molecular Cell & Systems Biology, School of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Bhella D; MRC Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom., Touyz RM; Institute of Cardiovascular and Medical Sciences, Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Jamieson AG; School of Chemistry, University of Glasgow, Glasgow, United Kingdom., Baillie GS; Institute of Cardiovascular and Medical Sciences, Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Blair CM; Institute of Cardiovascular and Medical Sciences, Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Publikováno v: PloS one [PLoS One] 2021 Nov 18; Vol. 16 (11), pp. e0260283. Date of Electronic Publication: 2021 Nov 18 (Print Publication: 2021).