Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins

Autor: Xeni Miliara, Takashi Tatsuta, Jamie-Lee Berry, Sarah L. Rouse, Kübra Solak, Dror S. Chorev, Di Wu, Carol V. Robinson, Stephen Matthews, Thomas Langer

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

The Ups/PRELI family mediates intramitochondrial lipid distribution and synthesis by shuttling phospholipids between both mitochondrial membranes. Here the authors combine X-ray crystallography, MD simulations and yeast genetic screens and identify r

Externí odkaz: https://doaj.org/article/51be78de046c436f8df261a65888f530

Functional analysis of the interdependence between DNA uptake sequence and its cognate ComP receptor during natural transformation in Neisseria species.

Autor: Jamie-Lee Berry, Ana Cehovin, Melanie A McDowell, Susan M Lea, Vladimir Pelicic

Publikováno v: PLoS Genetics, Vol 9, Iss 12, p e1004014 (2013)

Natural transformation is the widespread biological process by which "competent" bacteria take up free DNA, incorporate it into their genomes, and become genetically altered or "transformed". To curb often deleterious transformation by foreign DNA, s

Externí odkaz: https://doaj.org/article/042852504f18431baa5dcd62913c8fa3

Characterization of a glycan-binding complex of minor pilins completes the analysis of Streptococcus sanguinis type 4 pili subunits

Autor: Meriam Shahin, Devon Sheppard, Claire Raynaud, Jamie-Lee Berry, Ishwori Gurung, Lisete M. Silva, Ten Feizi, Yan Liu, Vladimir Pelicic

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (3), pp.e2216237120. ⟨10.1073/pnas.2216237120⟩

Type 4 filaments (T4F)—of which type 4 pili (T4P) are the archetype—are a superfamily of nanomachines nearly ubiquitous in prokaryotes. T4F are polymers of one major pilin, which also contain minor pilins whose roles are often poorly understood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21634286f3cf6d26c2b69d01dd0edfb
http://hdl.handle.net/10044/1/102185

Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins

Autor: Dror S. Chorev, Carol V. Robinson, Xeni Miliara, Takashi Tatsuta, Jamie-Lee Berry, Kuebra Solak, Sarah L. Rouse, Stephen Matthews, Thomas Langer, Di Wu

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nat Commun
Nature Communications

Conserved lipid transfer proteins of the Ups/PRELI family regulate lipid accumulation in mitochondria by shuttling phospholipids in a lipid-specific manner across the intermembrane space. Here, we combine structural analysis, unbiased genetic approac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4257fce90f5c49fd8fac77fb718ef769
https://doaj.org/article/51be78de046c436f8df261a65888f530

PilB from Streptococcus sanguinis is a bimodular type IV pilin with a direct role in adhesion

Autor: Vladimir Pelicic, Jamie-Lee Berry, Devon Sheppard, Claire Raynaud, Ishwori Gurung

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (22), pp.e2102092118. ⟨10.1073/pnas.2102092118⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (22), pp.e2102092118. ⟨10.1073/pnas.2102092118⟩

International audience; Type IV pili (T4P) are functionally versatile filamentous nanomachines, nearly ubiquitous in prokaryotes. They are predominantly polymers of one major pilin but also contain minor pilins whose functions are often poorly define

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef1d755ccc23b48d8a83e7b35d555a8
https://hal.science/hal-03512351/document