Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jamie Zagozewski"'
Autor:
Emma Martell, Helgi Kuzmychova, Esha Kaul, Harshal Senthil, Subir Roy Chowdhury, Ludivine Coudière Morrison, Agnes Fresnoza, Jamie Zagozewski, Chitra Venugopal, Chris M. Anderson, Sheila K. Singh, Versha Banerji, Tamra E. Werbowetski-Ogilvie, Tanveer Sharif
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-26 (2023)
Abstract Group 3 medulloblastoma (G3 MB) carries the worst prognosis of all MB subgroups. MYC oncoprotein is elevated in G3 MB tumors; however, the mechanisms that support MYC abundance remain unclear. Using metabolic and mechanistic profiling, we pi
Externí odkaz:
https://doaj.org/article/5c5a7943a1a04bfc88a6392559029355
Autor:
Jamie Zagozewski, Stephanie Borlase, Brent J. Guppy, Ludivine Coudière-Morrison, Ghazaleh M. Shahriary, Victor Gordon, Lisa Liang, Stephen Cheng, Christopher J. Porter, Rhonda Kelley, Cynthia Hawkins, Jennifer A. Chan, Yan Liang, Jingjing Gong, Carolina Nör, Olivier Saulnier, Robert J. Wechsler-Reya, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
RNA sequencing of MEK inhibitor (selumetinib)-treated tumors reveals an upregulation of the JAK/STAT3 pathway, with combinatorial therapeutic strategies of JAK/STAT3 inhibitors and selumetinib investigated for the SHH subgroup of medulloblastoma.
Externí odkaz:
https://doaj.org/article/7089de720db644bf9d6c9ef8dd5e7822
Autor:
Jamie Zagozewski, Ghazaleh M. Shahriary, Ludivine Coudière Morrison, Olivier Saulnier, Margaret Stromecki, Agnes Fresnoza, Gareth Palidwor, Christopher J. Porter, Antoine Forget, Olivier Ayrault, Cynthia Hawkins, Jennifer A. Chan, Maria C. Vladoiu, Lakshmikirupa Sundaresan, Janilyn Arsenio, Michael D. Taylor, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
OTX2 promotes tumour growth in Group 3 medulloblastoma. Here, the authors show that OTX2 regulates PAX3 to induce neural de-differentiation and promote tumourigenesis in Group 3 medulloblastoma.
Externí odkaz:
https://doaj.org/article/3dc6989adc56489cbc4b3348d8eb2070
Autor:
Margaret Stromecki, Nazanin Tatari, Ludivine Coudière Morrison, Ravinder Kaur, Jamie Zagozewski, Gareth Palidwor, Vijay Ramaswamy, Patryk Skowron, Matthias Wölfl, Till Milde, Marc R. Del Bigio, Michael D. Taylor, Tamra E. Werbowetski‐Ogilvie
Publikováno v:
Molecular Oncology, Vol 12, Iss 4, Pp 495-513 (2018)
Medulloblastoma (MB) is the most common malignant primary pediatric brain cancer. Among the most aggressive subtypes, Group 3 and Group 4 originate from stem/progenitor cells, frequently metastasize, and often display the worst prognosis, yet we know
Externí odkaz:
https://doaj.org/article/7bf98c7755da4eec9545cf267075d874
Autor:
Ludivine Coudière Morrison, Jennifer A. Chan, Margaret Stromecki, Gareth A. Palidwor, Maria C. Vladoiu, Cynthia Hawkins, Jamie Zagozewski, Tamra E. Werbowetski-Ogilvie, Ghazaleh M. Shahriary, Janilyn Arsenio, Olivier Ayrault, Lakshmikirupa Sundaresan, Vijay Ramaswamy, Antoine Forget, Agnes Fresnoza, Christopher J. Porter, Michael D. Taylor, Olivier Saulnier
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3627. ⟨10.1038/s41467-020-17357-4⟩
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, 2020, 11 (1), pp.3627. ⟨10.1038/s41467-020-17357-4⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3627. ⟨10.1038/s41467-020-17357-4⟩
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, 2020, 11 (1), pp.3627. ⟨10.1038/s41467-020-17357-4⟩
OTX2 is a potent oncogene that promotes tumor growth in Group 3 medulloblastoma. However, the mechanisms by which OTX2 represses neural differentiation are not well characterized. Here, we perform extensive multiomic analyses to identify an OTX2 regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459b190d3ef9954563e763e01f7f9b7e
https://www.hal.inserm.fr/inserm-02946666/document
https://www.hal.inserm.fr/inserm-02946666/document
In this study, we demonstrate that mouse DLX2 binds to theOlig2gene locus in mouse embryonic forebrainin vivo. We further confirm the specificity and the transcriptional repressive effect of the bindingin vitro. Furthermore, loss ofDlx1/2function lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6c132eecff0eb3cea0110c8ef6044e
https://doi.org/10.1101/2020.04.09.012385
https://doi.org/10.1101/2020.04.09.012385
Autor:
Trung N. Le, Tracie D Parkinson, David D. Eisenstat, Inma Cobos, Jerry Vriend, Sara Japoni, Qing-Ping Zhou, Shunzhen Zhang, Guoyan Du, John L.R. Rubenstein, Jamie Zagozewski
Publikováno v:
The Journal of Neuroscience. 37:8816-8829
GABA is the key inhibitory neurotransmitter in the cortex but regulation of its synthesis during forebrain development is poorly understood. In the telencephalon, members of the distal-less (Dlx) homeobox gene family are expressed in, and regulate th
Autor:
Ludivine Coudière Morrison, Jamie Zagozewski, Gareth A. Palidwor, Tamra E. Werbowetski-Ogilvie, Vijay Ramaswamy, Margaret Stromecki
Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor. Of the four distinct molecular MB subgroups, Group 3 MB has the worst prognosis, is highly metastatic, and is poorly defined with regard to the pathways that contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32628321bacdf19bcff554a0bf4912d
https://europepmc.org/articles/PMC6217684/
https://europepmc.org/articles/PMC6217684/
Publikováno v:
Methods in Molecular Biology ISBN: 9781493988044
Chromatin immunoprecipitation assays permit the isolation and subsequent identification of genomic DNA (gDNA) fragments bound directly or indirectly to proteins of interest, including transcription factors, co-factors, or chromatin remodeling protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7cfc331b1d1a3273422ce07bf11dae7
https://doi.org/10.1007/978-1-4939-8805-1_13
https://doi.org/10.1007/978-1-4939-8805-1_13
Autor:
Antoine Forget, Michael D. Taylor, Jamie Zagozewski, Jennifer A. Chan, Tamra E. Werbowetski-Ogilvie, Cynthia Hawkins, Agnes Fresnoza, Gareth A. Palidwor, Ludivine Coudière Morrison, Olivier Saulnier, Olivier Ayrault, Christopher J. Porter, Margaret Stromecki, Vijay Ramaswamy, Maria C. Vladoiu, Ghazaleh M. Shahriary
Publikováno v:
Neuro Oncol
The majority of Group 3 medulloblastomas (MB) exhibit amplification or increased expression of OTX2. OTX2 is primarily known as an oncogenic driver of tumor growth and cell cycle progression in Group 3 MB; however, its role as a repressor of differen