Endothelium-Derived Hyperpolarization and Coronary Vasodilation: Diverse and Integrated Roles of Epoxyeicosatrienoic Acids, Hydrogen Peroxide, and Gap Junctions

Autor: Yanping Liu, Jamie Y. Jeremy, Shaun L. Sandow, Nilima Shukla, David C. Ellinsworth, David D. Gutterman

Publikováno v: Microcirculation. 23:15-32

Myocardial perfusion and coronary vascular resistance are regulated by signalling metabolites released from the local myocardium that act either directly on the vascular smooth muscle cells (VSMC) or indirectly via stimulation of the endothelium. A p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e235b5f4a5522b6f26dcbfa4df355f
https://doi.org/10.1111/micc.12255

NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in human endothelial cells

Autor: Nilima Shukla, Gianni D Angelini, Jamie Y. Jeremy, Saima Muzaffar

Publikováno v: Journal of Cellular Physiology. 227:1941-1950

The protective actions of prostacyclin (PGI(2) ) are mediated by cyclic AMP (cAMP) which is reduced by type 4 phosphodiesterases (PDE4) which hydrolyze cAMP. Superoxide (O2(-)) from NADPH oxidase (Nox) is associated with impaired PGI(2) bioactivity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8cdfbc6c92a6bef588de23119301447
https://doi.org/10.1002/jcp.22922

Characterization of the Differential Response of Endothelial Cells Exposed to Normal and Elevated Laminar Shear Stress

Autor: Anton J.G. Horrevoets, Jamie Y. Jeremy, Stephen J. White, Andrew C. Newby, Elaine M Hayes, Stephanie Lehoux

Publikováno v: White, S J, Hayes, E M, Lehoux, S, Jeremy, J Y, Horrevoets, A J G & Newby, A C 2011, ' Characterization of the Differential Response of Endothelial Cells Exposed to Normal and Elevated Laminar Shear Stress ', Journal of Cellular Physiology, vol. 226, no. 11, pp. 2841-2848 . https://doi.org/10.1002/jcp.22629
Journal of Cellular Physiology, 226(11), 2841-2848. Wiley-Liss Inc.
Journal of Cellular Physiology

Most acute coronary events occur in the upstream region of stenotic atherosclerotic plaques that experience laminar shear stress (LSS) elevated above normal physiological levels. Many studies have described the atheroprotective effect on endothelial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee57cf930ec395047f7ac0269afaa804
https://hdl.handle.net/1871/36648

Oxidative Stress, Nitric Oxide, and Vascular Disease

Autor: Gianni D Angelini, Jamie Y. Jeremy, Song Wan, Anthony P.C. Yim

Publikováno v: Journal of Cardiac Surgery. 17:324-327

Superoxide (O2-) is a key risk factor for cardiovascular disease (CVD), including atherogenesis, reperfusion injury, angina, restenosis following balloon angioplasty, and vein graft failure. Axiomatically, O2- reacts with nitric oxide (NO) to form pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7883e7907386151142f2ae18de619772
https://doi.org/10.1111/j.1540-8191.2001.tb01151.x

Folic acid administration reduces neointimal thickening, augments neo-vasa vasorum formation and reduces oxidative stress in saphenous vein grafts from pigs used as a model of diabetes

Autor: Gianni D Angelini, Frank C T Smith, Jamie Y. Jeremy, Nilima Shukla, Jwj Bloor

Publikováno v: Diabetologia. 53:980-988

There is evidence that plasma homocysteine augments vein graft failure and that it augments both micro- and macro-angiopathy in patients with diabetes mellitus. It is therefore suggested that homocysteine may augment vein graft thickening, a major ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c963bff3392828bae93691e56e5064b
https://doi.org/10.1007/s00125-010-1680-5