Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jamie Toombs"'
Autor:
Jasmini Alagaratnam, Wolfgang Stöhr, Elizabeth Hamlyn, Kholoud Porter, Jamie Toombs, Amanda Heslegrave, Henrik Zetterberg, Magnus Gisslén, Jonathan Underwood, Mauro Schechter, Pontiano Kaleebu, Giuseppe Tambussi, Sabine Kinloch, Jose M. Miro, Anthony D. Kelleher, Abdel Babiker, John Frater, Alan Winston, Sarah Fidler
Publikováno v:
Journal of Virus Eradication, Vol 10, Iss 2, Pp 100381- (2024)
Objective: Antiretroviral therapy (ART)-conferred suppression of HIV replication limits neuronal injury and inflammation. ART interruption tests efficacy in HIV cure trials and viral rebound after ART interruption may induce neuronal injury. We inves
Externí odkaz:
https://doaj.org/article/487cf33da3b34fe190f0b5145c56c047
Autor:
Jasmini Alagaratnam, Wolfgang Stöhr, Jamie Toombs, Amanda Heslegrave, Henrik Zetterberg, Magnus Gisslén, Sarah Pett, Mark Nelson, Amanda Clarke, Nneka Nwokolo, Margaret A. Johnson, Maryam Khan, Tomas Hanke, Jakub Kopycinski, Lucy Dorrell, Julie Fox, Sabine Kinloch, Jonathan Underwood, Matthew Pace, John Frater, Alan Winston, Sarah Fidler
Publikováno v:
Journal of Virus Eradication, Vol 7, Iss 3, Pp 100056- (2021)
Objective: HIV-remission strategies including kick-and-kill could induce viral transcription and immune-activation in the central nervous system, potentially causing neuronal injury. We investigated the impact of kick-and-kill on plasma neurofilament
Externí odkaz:
https://doaj.org/article/e67c8ca158464981987f7ea91b16fef1
Autor:
Jamie Toombs, Lindsay Panther, Loren Ornelas, Chunyan Liu, Emilda Gomez, Raquel Martín-Ibáñez, Simon R. Cox, Stuart J. Ritchie, Sarah E. Harris, Adele Taylor, Paul Redmond, Tom C. Russ, Lee Murphy, James D. Cooper, Karen Burr, Bhuvaneish T. Selvaraj, Cathy Browne, Clive N. Svendsen, Sally A. Cowley, Ian J. Deary, Siddharthan Chandran, Tara L. Spires-Jones, Dhruv Sareen
Publikováno v:
Stem Cell Research, Vol 46, Iss , Pp 101851- (2020)
Cognitive decline is among the most feared aspects of ageing. We have generated induced pluripotent stem cells (iPSCs) from 24 people from the Lothian Birth Cohort 1936, whose cognitive ability was tested in childhood and in older age. Peripheral blo
Externí odkaz:
https://doaj.org/article/2ec95fdbbd9044aca4c3416f0ee6b4db
Autor:
Ross W. Paterson, Catherine F. Slattery, Teresa Poole, Jennifer M. Nicholas, Nadia K. Magdalinou, Jamie Toombs, Miles D. Chapman, Michael P. Lunn, Amanda J. Heslegrave, Martha S Foiani, Philip S. J. Weston, Ashvini Keshavan, Jonathan D. Rohrer, Martin N. Rossor, Jason D. Warren, Catherine J. Mummery, Kaj Blennow, Nick C. Fox, Henrik Zetterberg, Jonathan M. Schott
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-11 (2018)
Abstract Background Cerebrospinal fluid (CSF) biomarkers are increasingly being used to support a diagnosis of Alzheimer’s disease (AD). Their clinical utility for differentiating AD from non-AD neurodegenerative dementias, such as dementia with Le
Externí odkaz:
https://doaj.org/article/cd0b740c050b4d6384bd565c2c72b223
Autor:
Jamie Toombs, Martha S. Foiani, Henrietta Wellington, Ross W. Paterson, Charles Arber, Amanda Heslegrave, Michael P. Lunn, Jonathan M. Schott, Selina Wray, Henrik Zetterberg
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 311-321 (2018)
Abstract Introduction We tested the hypothesis that the amyloid β (Aβ) peptide ratios are more stable than Aβ42 alone when biofluids are exposed to two preanalytical conditions known to modify measurable Aβ concentration. Methods Human cerebrospi
Externí odkaz:
https://doaj.org/article/3548c29662c64b45a557c5845bb4dac5
Autor:
Tammaryn Lashley, Jonathan M. Schott, Philip Weston, Christina E. Murray, Henny Wellington, Ashvini Keshavan, Sandrine C. Foti, Martha Foiani, Jamie Toombs, Jonathan D. Rohrer, Amanda Heslegrave, Henrik Zetterberg
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 5 (2018)
The neurodegenerative disorder Alzheimer's disease is characterised by the formation of β-amyloid plaques and neurofibrillary tangles in the brain parenchyma, which cause synapse and neuronal loss. This leads to clinical symptoms, such as progressiv
Externí odkaz:
https://doaj.org/article/ce11342f6c0248c4852ea31673909092
Autor:
Ross W. Paterson, Jamie Toombs, Miles D. Chapman, Jennifer M. Nicholas, Amanda J. Heslegrave, Catherine F. Slattery, Alexander J.M. Foulkes, Camilla N. Clark, Christopher A.S. Lane, Philip S.J. Weston, Michael P. Lunn, Nick C. Fox, Henrik Zetterberg, Jonathan M. Schott
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 1, Iss 3, Pp 380-384 (2015)
Abstract Introduction Cerebrospinal fluid (CSF) neurodegenerative markers are measured clinically to support a diagnosis of Alzheimer's disease. Several preanalytical factors may alter the CSF concentrations of amyloid β 1–42 (Aβ1–42) in partic
Externí odkaz:
https://doaj.org/article/13480e2160d744c9985b1d432b6a50d2
Autor:
Nicholas GD Masca, Elizabeth MA Hensor, Victoria R Cornelius, Francesca M Buffa, Helen M Marriott, James M Eales, Michael P Messenger, Amy E Anderson, Chris Boot, Catey Bunce, Robert D Goldin, Jessica Harris, Rod F Hinchliffe, Hiba Junaid, Shaun Kingston, Carmen Martin-Ruiz, Christopher P Nelson, Janet Peacock, Paul T Seed, Bethany Shinkins, Karl J Staples, Jamie Toombs, Adam KA Wright, M Dawn Teare
Publikováno v:
eLife, Vol 4 (2015)
Lack of reproducibility is an ongoing problem in some areas of the biomedical sciences. Poor experimental design and a failure to engage with experienced statisticians at key stages in the design and analysis of experiments are two factors that contr
Externí odkaz:
https://doaj.org/article/a0d7e699f1c042edb9b4707dd4859347
Autor:
Nanet Willumsen, Charles Arber, Christopher Lovejoy, Jamie Toombs, Argyro Alatza, Philip S J Weston, Lucia Chávez-Gutiérrez, John Hardy, Henrik Zetterberg, Nick C Fox, Natalie S Ryan, Tammaryn Lashley, Selina Wray
Publikováno v:
Brain Communications. 5
Mutations in the presenilin 1 gene, PSEN1, which cause familial Alzheimer's disease alter the processing of amyloid precursor protein, leading to the generation of various amyloid-β peptide species. These species differ in their potential for aggreg
Autor:
Declan King, Kris Holt, Jamie Toombs, Xin HE, Owen Dando, Judith A Okely, Makis Tzioras, Jamie Rose, Ciaran Gunn, Adele Correia, Carmen Montero, Hannah McAlister, Jane Tulloch, Douglas Lamont, Adele M Taylor, Sarah E Harris, Paul Redmond, Simon R Cox, Christopher M Henstridge, Ian J Deary, Colin Smith, Tara L Spires‐Jones
Publikováno v:
King, D, Holt, K, Toombs, J, He, X, Dando, O, Okely, J, Rose, J, Gunn, C, Correia, A, Montero, C, Tulloch, J, Lamont, D, Taylor, A, Harris, S, Redmond, P, Cox, S R, Henstridge, C, Deary, I J, Smith, C & Spires-Jones, T 2022, ' Synaptic resilience is associated with maintained cognition during ageing ', Alzheimer's & Dementia: The Journal of the Alzheimer's Association . https://doi.org/10.1002/alz.12894
INTRODUCTION It remains unclear why age increases risk of Alzheimer’s disease and why some people experience age-related cognitive decline in the absence of dementia. Here we test the hypothesis that resilience to molecular changes in synapses cont