Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jamie T. Bridgham"'
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Toll-like receptor 4 (TLR4) induces inflammation in response to both pathogen- and host-derived molecules. Lipopolysaccharide (LPS) recognition by TLR4 has been shown to occur across the amniotes, but endogenous signaling through TLR4 has not been va
Externí odkaz:
https://doaj.org/article/14c113dbcda34d1d8214aaf41e6ace4b
Publikováno v:
Molecular Biology and Evolution
Hypotheses about the functions of ancient proteins and the effects of historical mutations on them are often tested using ancestral protein reconstruction (APR)-phylogenetic inference of ancestral sequences followed by synthesis and experimental char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860620eb38cc09b4ad1c08423f15c201
http://europepmc.org/articles/PMC6095102
http://europepmc.org/articles/PMC6095102
Autor:
Hanna B. Buechi, Jamie T. Bridgham
Publikováno v:
General and Comparative Endocrinology.
Glycoprotein hormones (GpH) interact very specifically with their receptors to mediate hypothalamic-pituitary-peripheral gland endocrine signaling. Vertebrates typically have three functionally distinct GpH endocrine signaling complexes: follicle-sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9233f90114fbefc3c9e4ac5e71e135
Autor:
Eric A. Ortlund, Dave W. Anderson, Joseph W. Thornton, Michael N. Murphy, Alesia N. McKeown, Jamie T. Bridgham
Publikováno v:
Cell. 159:58-68
SummaryComplex gene regulatory networks require transcription factors (TFs) to bind distinct DNA sequences. To understand how novel TF specificity evolves, we combined phylogenetic, biochemical, and biophysical approaches to interrogate how DNA recog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a02dca1096b4565541f875c768a876
https://doi.org/10.1016/j.cell.2014.09.003
https://doi.org/10.1016/j.cell.2014.09.003
Publikováno v:
Molecular Biology and Evolution. 25:2643-2652
Specific interactions among proteins, nucleic acids, and metabolites drive virtually all cellular functions and underlie phenotypic complexity and diversity. Despite the fundamental importance of interactions, the mechanisms and dynamics by which the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835e0ef4250d340ebb083c9f81a43c64
https://doi.org/10.1093/molbev/msn204
https://doi.org/10.1093/molbev/msn204
Publikováno v:
Science. 317:1544-1548
The structural mechanisms by which proteins have evolved new functions are known only indirectly. We report x-ray crystal structures of a resurrected ancestral protein—the ∼450 million-year-old precursor of vertebrate glucocorticoid (GR) and mine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ce9556ed06c5f21c7b3f9ce44ac85f
https://doi.org/10.1126/science.1142819
https://doi.org/10.1126/science.1142819
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 309(3)
Whole animal physiological performance is highly polygenic and highly plastic, and the same is generally true for the many subordinate traits that underlie performance capacities. Quantitative genetics, therefore, provides an appropriate framework fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280c271222c30b6d5327f91696d847b2
https://pubmed.ncbi.nlm.nih.gov/26041111
https://pubmed.ncbi.nlm.nih.gov/26041111
Publikováno v:
Biology of Reproduction. 71:1844-1851
Undifferentiated granulosa cells from prehierarchal (6- to 8-mm-diameter) hen follicles express very low to undetectable levels of LH receptor (LH-R) mRNA, P450 cholesterol side chain cleavage (P450scc) enzyme activity, and steroidogenic acute regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a07e6f1ca699c30170fce70683eb169d
https://doi.org/10.1095/biolreprod.104.032573
https://doi.org/10.1095/biolreprod.104.032573
Autor:
Alan L. Johnson, Jamie T. Bridgham
Publikováno v:
Biology of Reproduction. 70:972-979
As a result of searching recently available chicken (ch) expressed sequence tag databases, a new Tumor Necrosis Factor Receptor Super Family (TNFRSF) member with similarity to the murine (m) TNFRSF23 decoy receptor (DcR) has been identified. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f87fdfb3d3576e4dbbd513657faa38a6
https://doi.org/10.1095/biolreprod.103.023614
https://doi.org/10.1095/biolreprod.103.023614
Autor:
Jamie T. Bridgham, Alan L. Johnson
Publikováno v:
Biochemical and Biophysical Research Communications. 307:956-961
Tumor necrosis factor (TNF) family ligands bind to death domain-containing TNF receptors (death receptors), which can subsequently activate intracellular signaling pathways to initiate caspase activity and apoptotic cell death. Decoy receptors, witho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf561153892adc1540806cda927f0903
https://doi.org/10.1016/s0006-291x(03)01304-4
https://doi.org/10.1016/s0006-291x(03)01304-4