Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Jamie S. Simpson"'
Autor:
Tim Quach, Luojuan Hu, Sifei Han, Shea F. Lim, Danielle Senyschyn, Preeti Yadav, Natalie L. Trevaskis, Jamie S. Simpson, Christopher J. H. Porter
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/028048587b0e4741b75102697e74ef15
Autor:
Tim Quach, Luojuan Hu, Sifei Han, Shea F. Lim, Danielle Senyschyn, Preeti Yadav, Natalie L. Trevaskis, Jamie S. Simpson, Christopher J. H. Porter
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Buprenorphine (BUP) is a potent opioid analgesic that is widely used for severe pain management and opioid replacement therapy. The oral bioavailability of BUP, however, is significantly limited by first-pass metabolism. Previous studies have shown t
Externí odkaz:
https://doaj.org/article/075b84dedb714267a4a31fc5ae8108b9
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271735 (2022)
Stinging nettle root and leaf extracts were tested for their effect on prostatic smooth muscle contractility. Root extract did not affect electrical field stimulation induced-nerve mediated contractions of isolated rat prostates. On the other hand, l
Externí odkaz:
https://doaj.org/article/77901f5906ba405280ca8c1bf025a3f2
Autor:
Sifei Han, Tim Quach, Luojuan Hu, Shea Fern Lim, Dan Zheng, Nathania J. Leong, Garima Sharma, Daniel Bonner, Jamie S. Simpson, Natalie L. Trevaskis, Christopher J.H. Porter
Publikováno v:
Molecular Pharmaceutics. 20:2675-2685
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06c742e85019a0b346d5ed0b17b54e0a
https://doi.org/10.1021/acs.molpharmaceut.3c00099
https://doi.org/10.1021/acs.molpharmaceut.3c00099
Autor:
Christopher J.H. Porter, Kian Liun Phang, Alina Lam, Vilena De Melo Ferreira, Gracia Gracia, Luojuan Hu, Hannah Chu, Tim Quach, Jamie S. Simpson, Alistair B.J. Escott, Anubhav Srivastava, Gabriela Segal, Jiwon Hong, Dovile Anderson, Sonya Agarwal, Darren J. Creek, Enyuan Cao, Natasha L. Harvey, Natalie L. Trevaskis, Anthony R. J. Phillips, John A. Windsor, Matthew J. Watt, Cameron J. Nowell
Publikováno v:
Nature Metabolism. 3:1175-1188
Refereed/Peer-reviewed Visceral adipose tissue (VAT) encases mesenteric lymphatic vessels and lymph nodes through which lymph is transported from the intestine and mesentery. Whether mesenteric lymphatics contribute to adipose tissue inflammation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593eca819097e7d1292753e034b33a25
https://doi.org/10.1038/s42255-021-00457-w
https://doi.org/10.1038/s42255-021-00457-w
Autor:
Biswaranjan Mohanty, Kieran Rimmer, Róisín M McMahon, Stephen J Headey, Mansha Vazirani, Stephen R Shouldice, Mathieu Coinçon, Stephanie Tay, Craig J Morton, Jamie S Simpson, Jennifer L Martin, Martin J Scanlon
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173436 (2017)
At a time when the antibiotic drug discovery pipeline has stalled, antibiotic resistance is accelerating with catastrophic implications for our ability to treat bacterial infections. Globally we face the prospect of a future when common infections ca
Externí odkaz:
https://doaj.org/article/622b291cbc23439dad3506ecbeaf3d70
Autor:
Jamie S. Simpson, Tim Quach, Christopher J.H. Porter, Gracia Gracia, Natalie L. Trevaskis, Shea Fern Lim, Luojuan Hu, Sifei Han
Publikováno v:
Journal of Pharmaceutical Sciences. 110:489-499
Drug delivery to the lymphatic system is gaining increasing attention, particularly in fields such as immunotherapy where drug access to lymphocytes is central to activity. We have previously described a prodrug strategy that facilitates the lymphati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b43b721e3deedcfa8b1d97b15c3478
https://doi.org/10.1016/j.xphs.2020.10.021
https://doi.org/10.1016/j.xphs.2020.10.021
Autor:
Geqing Wang, Christopher A MacRaild, Biswaranjan Mohanty, Mehdi Mobli, Nathan P Cowieson, Robin F Anders, Jamie S Simpson, Sheena McGowan, Raymond S Norton, Martin J Scanlon
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109674 (2014)
Apical membrane antigen 1 (AMA1) of the human malaria parasite Plasmodium falciparum has been implicated in invasion of the host erythrocyte. It interacts with malarial rhoptry neck (RON) proteins in the moving junction that forms between the host ce
Externí odkaz:
https://doaj.org/article/a51fd55313c34feba2785836de28f0c3
Autor:
Enyuan, Cao, Matthew J, Watt, Cameron J, Nowell, Tim, Quach, Jamie S, Simpson, Vilena, De Melo Ferreira, Sonya, Agarwal, Hannah, Chu, Anubhav, Srivastava, Dovile, Anderson, Gracia, Gracia, Alina, Lam, Gabriela, Segal, Jiwon, Hong, Luojuan, Hu, Kian Liun, Phang, Alistair B J, Escott, John A, Windsor, Anthony R J, Phillips, Darren J, Creek, Natasha L, Harvey, Christopher J H, Porter, Natalie L, Trevaskis
Publikováno v:
Nature metabolism. 3(9)
Visceral adipose tissue (VAT) encases mesenteric lymphatic vessels and lymph nodes through which lymph is transported from the intestine and mesentery. Whether mesenteric lymphatics contribute to adipose tissue inflammation and metabolism and insulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f54fa454d90ea2f63dce42a2283feb72
https://pubmed.ncbi.nlm.nih.gov/34663931
https://pubmed.ncbi.nlm.nih.gov/34663931
Autor:
Sandeep Chhabra, Olan Dolezal, Brett M Collins, Janet Newman, Jamie S Simpson, Ian G Macreadie, Ross Fernley, Thomas S Peat, James D Swarbrick
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29444 (2012)
The first structural and biophysical data on the folate biosynthesis pathway enzyme and drug target, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (SaHPPK), from the pathogen Staphylococcus aureus is presented. HPPK is the second essential enzy
Externí odkaz:
https://doaj.org/article/1f609177ee9340e58a5cb79334853dbc