Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jamie S Mitchell"'
Autor:
Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert‐Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie‐Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 22-31 (2018)
Abstract Intronic GGGGCC repeat expansions in C9orf72 are the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which are characterised by degeneration of cortical and motor neurons, respectively. Repea
Externí odkaz:
https://doaj.org/article/1f8b61ee6cea4757929c90eeb5c2d015
Autor:
Sara Martina Maffioletti, Shilpita Sarcar, Alexander B.H. Henderson, Ingra Mannhardt, Luca Pinton, Louise Anne Moyle, Heather Steele-Stallard, Ornella Cappellari, Kim E. Wells, Giulia Ferrari, Jamie S. Mitchell, Giulia E. Tyzack, Vassilios N. Kotiadis, Moustafa Khedr, Martina Ragazzi, Weixin Wang, Michael R. Duchen, Rickie Patani, Peter S. Zammit, Dominic J. Wells, Thomas Eschenhagen, Francesco Saverio Tedesco
Publikováno v:
Cell Reports, Vol 23, Iss 3, Pp 899-908 (2018)
Summary: Generating human skeletal muscle models is instrumental for investigating muscle pathology and therapy. Here, we report the generation of three-dimensional (3D) artificial skeletal muscle tissue from human pluripotent stem cells, including i
Externí odkaz:
https://doaj.org/article/8b22248a00a9498bb213b38f5d00c2e3
Autor:
Filipa Almeida, Kavitha Siva, Oscar G. Wilkins, Gurvir S. Virdi, Warren Emmett, Elisavet Preza, Michela A. Denti, Jernej Ule, Claudia Manzoni, Alessandro Quattrone, Daniah Trabzuni, Victoria Kay, Mina Ryten, Thomas T. Warner, Roberto Simone, Jamie S. Mitchell, Natalia Barahona-Torres, Demis A. Kia, Per Svenningsson, Mazdak Ehteramyan, Andrew J. Lees, Raffaele Ferrari, Angelika Modelska, Geshanthi Hondhamuni, Jasmine Harley, Rohan de Silva, Vincent Plagnol, Rickie Patani, Alan Pittman, Justyna Zareba-Paslawska, John Hardy, Faiza Javad, Paola Zuccotti, Selina Wray
Publikováno v:
Nature
The human genome expresses thousands of natural antisense transcripts (NAT) that can regulate epigenetic state, transcription, RNA stability or translation of their overlapping genes1,2. Here we describe MAPT-AS1, a brain-enriched NAT that is conserv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d272b40dfe02a5f8381bb307045a35b
https://openaccess.sgul.ac.uk/id/eprint/113282/1/Simone2021_2016-04-05263D_text-Figures_final.pdf
https://openaccess.sgul.ac.uk/id/eprint/113282/1/Simone2021_2016-04-05263D_text-Figures_final.pdf
Autor:
Miha Modic, Jamie S. Mitchell, Jacob Neeves, Jernej Ule, Linda Greensmith, Raphaëlle Luisier, Doaa M Taha, Jia Newcombe, Ione Meyer, Giulia E. Tyzack, Rickie Patani, Nicholas M. Luscombe
Publikováno v:
Brain
See Vidal and Atkin (doi:10.1093/brain/awz256) for a scientific commentary on this article. ALS remains incurable due to an incomplete understanding of its molecular pathogenesis. Tyzack, Luisier et al. report that FUS protein, previously thought to
Autor:
Igor Kosvin, William Krzewick, Larry Zanca, Kevin Wellwood, Peter Cash, Jamie S. Mitchell, John Bollettiero
Publikováno v:
Proceedings of the 2020 International Technical Meeting of The Institute of Navigation.
The Miniature Atomic Clock (MAC) was developed out of the same size and power-reducing technology, known as Coherent Population Trapping (CPT), as the venerable Chip Scale Atomic Clock (CSAC)[1]. By implementing low-power lasers as opposed to traditi
Autor:
Jamie S. Mitchell, Peter J. Hutchinson, Rickie Patani, Eric Peter Thelin, Susan Giorgi-Coll, Giulia E. Tyzack, Keri L. H. Carpenter, Adel Helmy, Arvid Frostell, Tamara Tajsic, Claire E. Hall, Aftab Alam
Publikováno v:
Journal of Neurotrauma
Neuroinflammation has been shown to mediate the pathophysiological response following traumatic brain injury (TBI). Accumulating evidence implicates astrocytes as key immune cells within the central nervous system (CNS), displaying both pro- and anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f44e1a34b7bdde985bbfc8f5cb8094
https://www.repository.cam.ac.uk/handle/1810/297249
https://www.repository.cam.ac.uk/handle/1810/297249
Autor:
Linda Partridge, Adrian M. Isaacs, Annora Thoeng, Sebastian Grönke, Jamie S. Mitchell, Sarah Mizielinska, Henrik Zetterberg, Charlotte E. Ridler, Amanda Heslegrave, Teresa Niccoli, Jacqueline Esser, Thomas G. Moens
Publikováno v:
Acta Neuropathologica
Moens, T G, Mizielinska, S, Niccoli, T, Mitchell, J S, Thoeng, A, Ridler, C E, Grönke, S, Esser, J, Heslegrave, A, Zetterberg, H, Partridge, L & Isaacs, A M 2018, ' Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD ', Acta Neuropathologica, vol. 135, no. 3, pp. 445-457 . https://doi.org/10.1007/s00401-017-1798-3
Acta Neuropathol
Moens, T G, Mizielinska, S, Niccoli, T, Mitchell, J S, Thoeng, A, Ridler, C E, Grönke, S, Esser, J, Heslegrave, A, Zetterberg, H, Partridge, L & Isaacs, A M 2018, ' Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD ', Acta Neuropathologica, vol. 135, no. 3, pp. 445-457 . https://doi.org/10.1007/s00401-017-1798-3
Acta Neuropathol
A GGGGCC hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Neurodegeneration may occur via transcription of the repeats into inherently toxic repetitive
Autor:
Emmanuel Risse, Phillip Smethurst, Jamie S. Mitchell, John Collinge, Giulia E. Tyzack, Jia Newcombe, Rickie Patani, Doaa M Taha, Katie Sidle, Yun-Ru Chen
Publikováno v:
Brain
Smethurst et al. develop a human, clinically relevant modelling platform that recapitulates key aspects of sporadic ALS. They demonstrate cell type-specific vulnerability to both seeded aggregation (induced by post-mortem tissue extracts) and upon tr
Autor:
Nicholas M. Luscombe, Jamie S. Mitchell, Jernej Ule, Miha Modic, Jia Newcombe, Linda Greensmith, Rickie Patani, Doaa M Taha, Jacob Neeves, Raphaëlle Luisier, Giulia E. Tyzack, Ione Meyer
Rare amyotrophic lateral sclerosis (ALS)-causing mutations clearly implicate ubiquitously expressed and predominantly nuclear RNA binding proteins (RBPs), which form pathological cytoplasmic inclusions in this context. However, it remains possible th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47c36837e47bc574bd183c6c2e1a6d7
Publikováno v:
Neuromuscular Disorders. 28:S24-S25