Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Jamie R.M. Webster"'
1
Targeting Non-Canonical Pathways as a Strategy to Modulate the NIS Symporter
Autor: Mohammed Alshahrani, Hannah Nieto, Ling Zha, Christopher McCabe, Jamie R.M. Webster, Katie Brookes, Rashida Khan, Alice Fletcher, Vicki Smith, Moray J. Campbell, Luke J. Alderwick, Patricia Borges de Souza, Kristien Boelaert, Martin L. Read, Caitlin Thornton
Publikováno v: SSRN Electronic Journal.
The sodium iodide symporter (NIS) functions to transport iodide and is critical for successful radioiodide ablation of cancer cells. Approaches to bolster NIS function and diminish recurrence post-radioiodide therapy are impeded by oncogenic pathways
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4022b1fbd178bec7598f8b94421aa1e
https://doi.org/10.2139/ssrn.3797274
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4
Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter
Autor: Luke J. Alderwick, Christopher McCabe, Kristien Boelaert, Katie Brookes, Ling Zha, Martin L. Read, Jamie R.M. Webster, Alice Fletcher, Moray J. Campbell, Patricia Borges de Souza, Vicki Smith, Caitlin Thornton, Mohammed Alshahrani, Rashida Khan, Hannah Nieto
Publikováno v: Cell Chemical Biology. 29:502-516.e7
The sodium iodide symporter (NIS) functions to transport iodide and is critical for successful radioiodide ablation of cancer cells. Approaches to bolster NIS function and diminish recurrence post-radioiodide therapy are impeded by oncogenic pathways
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::479656c8148e5299a116ee966df4ea64
https://doi.org/10.1016/j.chembiol.2021.07.016
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6
Abstract PO-006: Exploiting non-canonical pathways of NIS regulation to enhance radioiodide uptake and identify predictive markers of recurrence in thyroid cancer
Autor: Christopher McCabe, Katie Brookes, Patricia Borges de Souza, Martin L. Read, Alice Fletcher, Kristien Boelaert, Jamie R.M. Webster, Mohammed Alshahrani, Luke J. Alderwick, Vicki Smith, Ling Zha, Caitlin Thornton, Hannah Nieto
Publikováno v: Clinical Cancer Research. 27:PO-006
For >75 years radioiodide (RAI) has been used to target metastases and safely and specifically destroy remaining thyroid cancer cells post-surgery. Despite this, activity of the sodium iodide symporter (NIS) – the sole conduit for cellular iodide u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::418d80b4e41156cd93fe8a974bda33e2
https://doi.org/10.1158/1557-3265.radsci21-po-006
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7
Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer
Autor: Aysha M. Aljaberi, Jamie R.M. Webster, Sally P. Wheatley
Publikováno v: Cancer Cell International
Background: Survivin is a protein that is normally present only in G2 and M-phases in somatic cells, however, in cancer cells, it is expressed throughout the cell cycle. A prosurvival factor, survivin is both an inhibitor of apoptosis and an essentia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311472025cb369706ffdcec6f46490ec
https://doi.org/10.1186/s12935-014-0078-8
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8
Sox2 acts as a transcriptional repressor in neural stem cells
Autor: Sally P. Wheatley, Jaime Hughes, Paul J. Scotting, Jamie R.M. Webster, Paul E Goodwin, Zulfiqar Ali Laghari, Yu-Ru Liu, Carolina A Novoa
Publikováno v: BMC Neuroscience
Background The transcription factor, Sox2, is central to the behaviour of neural stem cells. It is also one of the key embryonic stem cell factors that, when overexpressed can convert somatic cells into induced pluripotent cells. Although generally s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c174e41eb07f909906abb4aa53fde7b
https://doi.org/10.1186/1471-2202-15-95
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