Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Jamie R. Milligan"'
Publikováno v:
Dose-Response, Vol 6 (2008)
Working under the assumption that hormesis is triggered by specific types of DNA damage, this report focuses on the types of damage which form the signature of ionizing radiation. The key attribute of the signature is the clustering of damage, arisin
Externí odkaz:
https://doaj.org/article/74c3fd72e9904a97835e04bfdab47bd6
Publikováno v:
Biomacromolecules. 22:1675-1684
The compound 4-dihydroxyboryl-l-phenylalanine (BPA) has found use in clinical trials of boron neutron capture therapy (BNCT). Here, we have examined the interaction with DNA of an amide-blocked BPA derivative of hexa-l-arginine (Ac-BPA-Arg6-NH2). Phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690cc15e5ff741c567bfea0657e16e7c
https://doi.org/10.1021/acs.biomac.1c00106
https://doi.org/10.1021/acs.biomac.1c00106
Autor:
Harald Paganetti, Sebastien Incerti, Bruce A. Faddegon, J A LaVerne, K Stefanová, N. Dominguez-Kondo, Václav Štěpán, J Perl, Aimee L. McNamara, José Ramos-Méndez, W-G Shin, Jan Schuemann, Carmen Villagrasa, Jamie R. Milligan, Yann Perrot
Publikováno v:
Physics in medicine and biology, vol 66, iss 17
Phys Med Biol
Physics in Medicine and Biology
Physics in Medicine and Biology, IOP Publishing, 2021, 66 (17), pp.175026. ⟨10.1088/1361-6560/ac1f39⟩
Phys Med Biol
Physics in Medicine and Biology
Physics in Medicine and Biology, IOP Publishing, 2021, 66 (17), pp.175026. ⟨10.1088/1361-6560/ac1f39⟩
The chemical stage of the Monte Carlo track-structure simulation code Geant4-DNA has been revised and validated. The root-mean-square (RMS) empirical parameter that dictates the displacement of water molecules after an ionization and excitation event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1e2403024bc2576fadf0747449ae68
https://doi.org/10.1088/1361-6560/ac1f39
https://doi.org/10.1088/1361-6560/ac1f39
DNA condensation with a boron-containing cationic peptide for modeling boron neutron capture therapy
Publikováno v:
Radiat Phys Chem Oxf Engl 1993
The amino acid derivative 4-borono-L-phenylalanine (BPA) has been used in the radiation medicine technique boron neutron capture therapy (BNCT). Here we have characterized its interaction with DNA when incorporated into a positively charged hexa-L-ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47720870875727059de8f76e1229e892
https://doi.org/10.1016/j.radphyschem.2019.108521
https://doi.org/10.1016/j.radphyschem.2019.108521
Autor:
Jamie R. Milligan, Theodore S. Sabir, Chris T. Perry, Leah K. Rowland, R. Steven Kurti, A. Wilson Aruni, Dong Yan, Qiao Chen, Danilo S. Boskovic
Publikováno v:
Langmuir. 29:3903-3911
We report the seeded synthesis of gold nanoparticles (GNPs) via the reduction of HAuCl4 by (L31 and F68) triblock copolymer (TBP) mixtures. In the present study, we focused on [TBP]/[Au(III)] ratios of 1–5 (≈ 1 mM HAuCl4) and seed sizes ~ 20 nm.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7816c24a756e450f0a3ee64c501339
https://doi.org/10.1021/la400387h
https://doi.org/10.1021/la400387h
Publikováno v:
Nucleic Acids Research
Our mechanistic understanding of damage formation in DNA by the direct effect relies heavily on what is known of free radical intermediates studied by EPR spectroscopy. Bridging this information to stable product formation requires methods with compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5bc229013ed8e990d1a804de35f24b1
https://doi.org/10.1093/nar/gks271
https://doi.org/10.1093/nar/gks271
Autor:
Dong Yan, Joseph A. Hughes, R. Steven Kurti, Kevin E. Nick, Ruth H. Ramon, Theodore S. Sabir, Qiao Chen, Jamie R. Milligan, A. Wilson Aruni, Chris T. Perry
Publikováno v:
The Journal of Physical Chemistry C. 116:4431-4441
Concerns for the environmental and economic impact of organic solvents and detergents in gold nanoparticle (AuNP) solution synthesis have motivated the search for more environmentally benign altern...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef8854c66976cb6486375f4ab60f72bc
https://doi.org/10.1021/jp210591h
https://doi.org/10.1021/jp210591h
Publikováno v:
Radiation Physics and Chemistry. 81:46-51
The hydroxyl radical is the primary mediator of DNA damage by the indirect effect of ionizing radiation. It is a powerful oxidizing agent produced by the radiolysis of water and is responsible for a significant fraction of the DNA damage associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba5a49220399dc5f84ac3ad2a8b4636
https://doi.org/10.1016/j.radphyschem.2011.09.006
https://doi.org/10.1016/j.radphyschem.2011.09.006
Publikováno v:
International Journal of Radiation Biology. 88:230-238
Electron deficient guanine radical species are major intermediates produced in DNA by the direct effect of ionizing irradiation. There is evidence that they react with amine groups in closely bound ligands to form covalent crosslinks. Crosslink forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b878c7558008141098a4de2e209bf290
https://doi.org/10.3109/09553002.2012.643853
https://doi.org/10.3109/09553002.2012.643853
Autor:
Danilo S. Boskovic, Wesley J. Livingston, Qiao Chen, Chris T. Perry, Jamie R. Milligan, Theodore S. Sabir, Victoria K. Maskiewicz
Publikováno v:
Journal of Colloid and Interface Science. 354:662-669
We present a novel approach of using the butylated hydroxytoluene (BHT) antioxidant found in commercial Pluronic F127 samples as a marker of polymer aggregation. The BHT marker was compared to the pyrene dye and static light scattering methods as a w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f5a786c30c5f117ee17f65845b9fda
https://doi.org/10.1016/j.jcis.2010.10.028
https://doi.org/10.1016/j.jcis.2010.10.028