Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jamie R. Doyle"'
Autor:
Kathleen M. Sicinski, Vittorio Montanari, Venkata S. Raman, Jamie R. Doyle, Benjamin N. Harwood, Yi Chi Song, Micaella P. Fagan, Maribel Rios, David R. Haines, Alan S. Kopin, Martin Beinborn, Krishna Kumar
Publikováno v:
ACS Central Science, Vol 7, Iss 3, Pp 454-466 (2021)
Externí odkaz:
https://doaj.org/article/0801e8218c0d49fab074c95cdbfeee66
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 3, Pp 823-830 (2013)
The hydroxy-carboxylic acid receptor (HCA1) is a G protein-coupled receptor that is highly expressed on adipocytes and considered a potential target for the treatment of dyslipidemia. In the current study, we investigated the pharmacological properti
Externí odkaz:
https://doaj.org/article/ddb9cf2c90a84fd2a0981d13c1201029
Autor:
C. Kors van der Ent, Renske van der Meer, Sylvia F. Boj, Robert G.J. Vries, Harry G.M. Heijerman, Peter van Mourik, Paul K. Audhya, Jamie R Doyle, Jeffrey M. Beekman, Zheng Jason Yuan, N. Kinnman, Gitte Berkers
Publikováno v:
Journal of Cystic Fibrosis. 20:761-767
Background Previous in vitro organoid data showed A455E–CFTR, a rare CFTR mutation with 4.1% prevalence in the Netherlands, responds to lumacaftor/ivacaftor (LUM/IVA). We explored LUM/IVA's clinical efficacy in people with CF and ≥1 A455E–CFTR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e7cd4bc1b9aa6bdfa4cf0c9c20123f
https://doi.org/10.1016/j.jcf.2020.11.007
https://doi.org/10.1016/j.jcf.2020.11.007
Autor:
Malena Cohen-Cymberknoh, Eitan Kerem, Michael Wilschanski, Alex Gileles-Hillel, Christopher Short, C DeSouza, Thea Pugatsch, Reuven Tsabari, Clare Saunders, Joel Reiter, James C. Sullivan, N. Kinnman, David Shoseyov, Jane C. Davies, Jamie R Doyle, Keval Chandarana
Publikováno v:
Annals of the American Thoracic Society. 18:433-441
Rationale: Ivacaftor's clinical effects in the residual function mutations 3849+10kb C →T and D1152H warrant further characterization. Objectives: Evaluate ivacaftor's effect in people with cystic fibrosis aged ≥6 years with 3849+10kb C→T or D1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0731e4c28904795edb4b358651e20d7e
https://doi.org/10.1513/annalsats.202006-659oc
https://doi.org/10.1513/annalsats.202006-659oc
Autor:
Alan S. Kopin, Martin Beinborn, Micaella P Fagan, Jamie R. Doyle, David R. Haines, Maribel Rios, Kathleen M Sicinski, Venkata S. Raman, Yi Chi Song, Krishna Kumar, Vittorio Montanari, Benjamin N. Harwood
Publikováno v:
ACS Central Science, Vol 7, Iss 3, Pp 454-466 (2021)
ACS Central Science
ACS Central Science
The gut-derived incretin hormone, glucagon-like peptide-1 (GLP1), plays an important physiological role in attenuating post-prandial blood glucose excursions in part by amplifying pancreatic insulin secretion. Native GLP1 is rapidly degraded by the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a981a6490ffab054d45057568971aa31
https://doaj.org/article/0801e8218c0d49fab074c95cdbfeee66
https://doaj.org/article/0801e8218c0d49fab074c95cdbfeee66
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112123 (2014)
One hallmark of obesity is adipocyte hypertrophy and hyperplasia. To gain novel insights into adipose biology and therapeutics, there is a pressing need for a robust, rapid, and informative cell model of adipocyte differentiation for potential RNAi a
Externí odkaz:
https://doaj.org/article/4081e964c6f740f6909bcd535619644c
Autor:
Jamie R Doyle, Benjamin N Harwood, Subrahmanian Tarakkad Krishnaji, Vijay M Krishnamurthy, Wei-En Lin, Jean-Philippe Fortin, Krishna Kumar, Alan S Kopin
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e110502 (2014)
Novel strategies are needed to expedite the generation and optimization of peptide probes targeting G protein-coupled receptors (GPCRs). We have previously shown that membrane tethered ligands (MTLs), recombinant proteins comprised of a membrane anch
Externí odkaz:
https://doaj.org/article/43b89814a6d64eacb23319dd84417b82
Autor:
Peter G. Fuerst, Ian J. Engerbretson, Nathan B. Reynolds, Michael J. Camerino, Bart G. Borghuis, Mikel H. Berria, Jamie R Doyle, Mellisa R. Clemons, Michael D. Gencarella, Parker A. Fife
Publikováno v:
J Comp Neurol
The neural retina is organized along central-peripheral, dorsal-ventral, and laminar planes. Cellular density and distributions vary along the central-peripheral and dorsal-ventral axis in species including primates, mice, fish, and birds. Differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34483c8a79603926e3d7dd2a654ef37b
https://europepmc.org/articles/PMC8009814/
https://europepmc.org/articles/PMC8009814/
Autor:
Eitan, Kerem, Malena, Cohen-Cymberknoh, Reuven, Tsabari, Michael, Wilschanski, Joel, Reiter, David, Shoseyov, Alex, Gileles-Hillel, Thea, Pugatsch, Jane C, Davies, Christopher, Short, Clare, Saunders, Cynthia, DeSouza, James C, Sullivan, Jamie R, Doyle, Keval, Chandarana, Nils, Kinnman
Publikováno v:
Annals of the American Thoracic Society. 18(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4186de30c40a4eb8d8658ae170513217
https://pubmed.ncbi.nlm.nih.gov/33095038
https://pubmed.ncbi.nlm.nih.gov/33095038
Autor:
null Michael J. Camerino, null Ian J. Engerbretson, null Parker A. Fife, null Nathan B. Reynolds, null Mikel H. Berria, null Jamie R. Doyle, null Mellisa R. Clemons, null Michael D. Gencarella, null Bart G. Borghuis, null Peter G. Fuerst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6464545a14311214a1a95694687ef0be
https://doi.org/10.1002/cne.25064/v3/response1
https://doi.org/10.1002/cne.25064/v3/response1