Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jamie R. Blundell"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Protein-protein interactions (PPIs) play a major role in defining biological functions. Here, the authors present PPiSeq, a method to quantitatively score dynamic PPIs in yeast combining fragment complementation assays, genomic double-barcoding, and
Externí odkaz:
https://doaj.org/article/a2d1f7e3c1634cb29a0d1f9355ce7b11
Autor:
Margaret A. Goodell, Benjamin L. Ebert, Wei Li, Jamie R. Blundell, Mathijs A. Sanders, Lionel Van Maldergem, Peter J.M. Valk, Alexander Meissner, Xiaodong Cheng, Yun Huang, Katrina Tatton-Brown, Yubin Zhou, Lorenzo Brunetti, Minjung Lee, Christina Galonska, Brielle R. Crovetti, Olga Dakhova, Jaime M. Reyes, Ayala Tovy, Caroline J. Watson, Dapeng Hao, Mikołaj Słabicki, Venkatasubramaniam Sundaramurthy, Chun-Wei Chen, Yung-Hsin Huang
Supplementary Figure from Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3397c680c3d88c32351ce8597d5c007f
https://doi.org/10.1158/2159-8290.22540261.v1
https://doi.org/10.1158/2159-8290.22540261.v1
Autor:
Margaret A. Goodell, Benjamin L. Ebert, Wei Li, Jamie R. Blundell, Mathijs A. Sanders, Lionel Van Maldergem, Peter J.M. Valk, Alexander Meissner, Xiaodong Cheng, Yun Huang, Katrina Tatton-Brown, Yubin Zhou, Lorenzo Brunetti, Minjung Lee, Christina Galonska, Brielle R. Crovetti, Olga Dakhova, Jaime M. Reyes, Ayala Tovy, Caroline J. Watson, Dapeng Hao, Mikołaj Słabicki, Venkatasubramaniam Sundaramurthy, Chun-Wei Chen, Yung-Hsin Huang
Supplementary Table from Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa65137d319df7cd6431c507ba65797
https://doi.org/10.1158/2159-8290.22540255
https://doi.org/10.1158/2159-8290.22540255
Autor:
Margaret A. Goodell, Benjamin L. Ebert, Wei Li, Jamie R. Blundell, Mathijs A. Sanders, Lionel Van Maldergem, Peter J.M. Valk, Alexander Meissner, Xiaodong Cheng, Yun Huang, Katrina Tatton-Brown, Yubin Zhou, Lorenzo Brunetti, Minjung Lee, Christina Galonska, Brielle R. Crovetti, Olga Dakhova, Jaime M. Reyes, Ayala Tovy, Caroline J. Watson, Dapeng Hao, Mikołaj Słabicki, Venkatasubramaniam Sundaramurthy, Chun-Wei Chen, Yung-Hsin Huang
Clonal hematopoiesis is a prevalent age-related condition associated with a greatly increased risk of hematologic disease; mutations in DNA methyltransferase 3A (DNMT3A) are the most common driver of this state. DNMT3A variants occur across the gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e91e313cc867f0f32398df58b6bf55f
https://doi.org/10.1158/2159-8290.c.6549331
https://doi.org/10.1158/2159-8290.c.6549331
Publikováno v:
Nature Genetics. 53:1597-1605
Genetic alterations under positive selection in healthy tissues have implications for cancer risk. However, total levels of positive selection across the genome remain unknown. Passenger mutations are influenced by all driver mutations, regardless of
Autor:
Iñigo Ayestaran, Jamie R. Blundell
T-cell receptor (TCR) repertoires provide a historical record of antigen exposure. However, the dynamics of TCR repertoires in healthy individuals remain largely uncharacterised. How much of the repertoire is under immune selection in healthy individ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e3f52afb309868da385186bf10081ed
https://doi.org/10.1101/2022.05.11.491566
https://doi.org/10.1101/2022.05.11.491566
Autor:
Caroline J. Watson, Jamie R. Blundell
Mosaic chromosomal alterations (mCAs) are commonly detected in many cancers and have been found to arise decades before diagnosis. A quantitative understanding of the rate at which these events occur and their functional consequences could improve ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2774a7bc01da2a46b42ed8e8a4a1fdc5
https://doi.org/10.1101/2022.05.07.491016
https://doi.org/10.1101/2022.05.07.491016
Autor:
Mikolaj Slabicki, Mathijs A. Sanders, Minjung Lee, Olga Dakhova, Jaime M. Reyes, Lionel Van Maldergem, Christina Galonska, Dapeng Hao, Margaret A. Goodell, Xiaodong Cheng, Peter J. M. Valk, Venkatasubramaniam Sundaramurthy, Caroline Watson, Chun-Wei Chen, Yung-Hsin Huang, Yubin Zhou, Ayala Tovy, Yun Huang, Alexander Meissner, Lorenzo Brunetti, Wei Li, Brielle R. Crovetti, Benjamin L. Ebert, Katrina Tatton-Brown, Jamie R. Blundell
Publikováno v:
Cancer Discovery
Cancer Discovery, 12(1), 220-235. American Association for Cancer Research Inc.
Cancer Discovery, 12(1), 220-235. American Association for Cancer Research Inc.
Clonal hematopoiesis is a prevalent age-related condition associated with a greatly increased risk of hematologic disease; mutations in DNA methyltransferase 3A (DNMT3A) are the most common driver of this state. DNMT3A variants occur across the gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa510b35a96d241e2486878bc3aac89
https://www.repository.cam.ac.uk/handle/1810/327471
https://www.repository.cam.ac.uk/handle/1810/327471
Autor:
Wing Hing Wong, Caroline Watson, A. L. Papula, Andrew L. Young, Todd E. Druley, Jamie R. Blundell, Gladys Y. P. Poon, Daniel S. Fisher
Publikováno v:
Science. 367:1449-1454
Evolutionary dynamics in hematopoiesis Cells accumulate mutations as we age, and these mutations can be a source of diseases such as cancer. How cells containing mutations evolve, are maintained, and proliferate within the body has not been well char
Publikováno v:
Nature genetics. 53(11)
Genetic alterations under positive selection in healthy tissues have implications for cancer risk. However, total levels of positive selection across the genome remain unknown. Passenger mutations are influenced by all driver mutations, regardless of