Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Jamie Miyamoto"'
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Data from Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index
Autor: Paul J. Carter, Hans-Peter Gerber, Stephen C. Alley, Robert Lyon, Jamie Miyamoto, Martha Anderson, Ivan Stone, Django Sussman, Tiffany Feist, Lori Westendorf, Lindsay L. Brown, Eileen Turcott, Kristine M. Kim, Charlotte F. McDonagh
An anti-CD70 antibody conjugated to monomethylauristatin F (MMAF) via a valine-citrulline dipeptide containing linker has been shown previously to have potent antitumor activity in renal cell cancer xenograft studies. Here, we generated a panel of hu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b708498a6daccb5aff53c86f1d7e7d6
https://doi.org/10.1158/1535-7163.c.6531668
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8
Abstract 1195: SGN-CD352A: A novel humanized anti-CD352 antibody-drug conjugate for the treatment of multiple myeloma
Autor: Kristine A. Gordon, Jamie Miyamoto, Martha Anderson, Che-Leung Law, Albina Nesterova, Heather Kostner, Lori Westendorf, Sharsti Sandall, Ivan Stone, Devra Olson, Timothy S. Lewis, Germein Linares, Chris Leiske, Mechthild Jonas
Publikováno v: Cancer Research. 76:1195-1195
Multiple myeloma (MM) is a hematologic malignancy of transformed plasma cells. In spite of recent advances, MM remains an incurable disease, underscoring the need to develop new targeted biological therapeutics to augment existing treatments. In this
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9e320397ea5bfe741f50ee646efd987
https://doi.org/10.1158/1538-7445.am2016-1195
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9
SGN-CD19B, a Pyrrolobenzodiazepine (PBD)-Based Anti-CD19 Drug Conjugate, Demonstrates Potent Preclinical Activity Against B-Cell Malignancies
Autor: Weiping Zeng, Martha Anderson, Heather A. Van Epps, Changpu Yu, Jamie Miyamoto, Dennis Benjamin, Kim Emmerton, Maureen Ryan, Heather Kostner, Brian Schimpf, Laurie Tatalick
Publikováno v: Blood. 126:594-594
Patients with relapsed or refractory B-cell non-Hodgkin lymphoma (r/r NHL) have a poor prognosis. Despite measurable clinical activity seen with new targeted therapies, most r/r NHL patients do not achieve a complete or durable response suggesting th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a65fe32098a5c9c4c7c42c88ad57597
https://doi.org/10.1182/blood.v126.23.594.594
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10
Proapoptotic signaling activity of the anti-CD40 monoclonal antibody dacetuzumab circumvents multiple oncogenic transformation events and chemosensitizes NHL cells
Autor: Jonathan G. Drachman, Renee McCormick, Kim K. Emmerton, Jamie Miyamoto, Brianna Mbow, Che-Leung Law, Iqbal S. Grewal, Timothy S. Lewis, Ivan Stone
Publikováno v: Leukemia. 25(6)
Non-Hodgkin lymphoma (NHL) is a genetically heterogeneous disease with several oncogenic events implicated in the transformation of normal developing B lymphocytes. The objective of this study was to elucidate the signal transduction-based antitumor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89691cdf7f5f5a54d8f1d9a51049dc14
https://pubmed.ncbi.nlm.nih.gov/21394099
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