Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jamie M. Bergen"'
Autor:
Jamie M. Bergen, Philip J. Horner, Russell N. Johnson, John Ravits, Heidi Back, Drew L. Sellers, Suzie H. Pun
Publikováno v:
Proceedings of the National Academy of Sciences. 113:2514-2519
A significant unmet need in treating neurodegenerative disease is effective methods for delivery of biologic drugs, such as peptides, proteins, or nucleic acids into the central nervous system (CNS). To date, there are no operative technologies for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5206612bf63d26087aa863619755dce
https://doi.org/10.1073/pnas.1515526113
https://doi.org/10.1073/pnas.1515526113
Autor:
David V. Schaffer, Jamie M. Bergen
Gene therapy, the introduction of therapeutic genetic material to cells to ameliorate disease or injury, holds great potential for the treatment of numerous disorders. However, broad clinical application of gene therapy is currently hindered by the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf22ce02f6dc363a958eb9b8f40a8c4d
https://doi.org/10.1016/b978-0-08-100691-7.00167-1
https://doi.org/10.1016/b978-0-08-100691-7.00167-1
Autor:
Jennifer R. Cochran, Jamie M. Bergen, You Rong S. Su, Melanie Hayden Gephart, Helen Rayburn, Sarah J. Moore, Matthew P. Scott
Publikováno v:
Proceedings of the National Academy of Sciences. 110:14598-14603
Central nervous system tumors carry grave clinical prognoses due to limited effectiveness of surgical resection, radiation, and chemotherapy. Thus, improved strategies for brain tumor visualization and targeted treatment are critically needed. We dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa07ad6a8e85443c34752d3bf7023b4b
https://doi.org/10.1073/pnas.1311333110
https://doi.org/10.1073/pnas.1311333110
Autor:
David A. Stoltz, David D. Dickey, Linda S. Powers, Michael J. Welsh, John R. Weinstein, John F. Engelhardt, Ziying Yan, Mahmoud H. Abou Alaiwa, Lynda S. Ostedgaard, Jamie M. Bergen, Xiaopeng Li, Katherine J. D. A. Excoffon, Drake C. Bouzek, Viral Shah, Nicholas D. Gansemer, Benjamin R. Steines, Patrick L. Sinn, David V. Schaffer, Joseph Zabner
Publikováno v:
JCI Insight. 1
The physiological components that contribute to cystic fibrosis (CF) lung disease are steadily being elucidated. Gene therapy could potentially correct these defects. CFTR-null pigs provide a relevant model to test gene therapy vectors. Using an in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37a774bb2d19141921be976cc2b7efc
https://doi.org/10.1172/jci.insight.88728
https://doi.org/10.1172/jci.insight.88728
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 30:321-326
Objectives— Vascular calcification is highly correlated with morbidity and mortality, and it is often associated with inflammation. Vitamin D may regulate vascular calcification and has been associated with cardiovascular survival benefits. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60682ab0c7a92d3217ff5c1b981a9eec
https://doi.org/10.1161/atvbaha.109.196576
https://doi.org/10.1161/atvbaha.109.196576
Autor:
Suzie H. Pun, Jamie M. Bergen
Publikováno v:
The Journal of Gene Medicine. 10:187-197
Background Neuron-specific, nonviral gene delivery vehicles are useful tools for the potential treatment of neurological disease and spinal cord injury. For minimally invasive, peripheral administration, gene carriers must efficiently mediate uptake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0774a0b3c79412861d1b9318dec3d2b
https://doi.org/10.1002/jgm.1137
https://doi.org/10.1002/jgm.1137
Publikováno v:
Bioconjugate Chemistry. 19:377-384
Nonviral gene carriers must associate with and become internalized by cells in order to mediate efficient transfection. Methods to quantitatively measure and distinguish between cell association and internalization of delivery vectors are necessary t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d7ab26eec68cdd75e91fbd34977287
https://doi.org/10.1021/bc700315v
https://doi.org/10.1021/bc700315v
Publikováno v:
Macromolecular Bioscience. 6:506-516
The development of targeted vehicles for systemic drug delivery relies on optimizing both the cell-targeting ligand and the physicochemical characteristics of the nanoparticle carrier. A versatile platform based on modification of gold nanoparticles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2596720fae7a2475b0fdedfab37eb786
https://doi.org/10.1002/mabi.200600075
https://doi.org/10.1002/mabi.200600075
Autor:
Jamie M. Bergen, Suzie H. Pun
Publikováno v:
MRS Bulletin. 30:663-667
Numerous barriers, both extracellular and intracellular, hinder successful and efficient nonviral nucleic acid delivery. Due to their small size and ability to specifically recognize and interact with molecular targets, peptides can be incorporated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a96d621f0f4ef9cc931b96271239e8d0
https://doi.org/10.1557/mrs2005.194
https://doi.org/10.1557/mrs2005.194
Publikováno v:
Expert review of proteomics. 11(5)
Cystine-knot miniproteins, also known as knottins, constitute a large family of structurally related peptides with diverse amino acid sequences and biological functions. Knottins have emerged as attractive candidates for drug development as they pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5334b251dba78e949ecf05e25a585bc1
https://pubmed.ncbi.nlm.nih.gov/25163524
https://pubmed.ncbi.nlm.nih.gov/25163524