Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Jamie M, O'Sullivan"'
Publikováno v:
Bleeding, Thrombosis and Vascular Biology, Vol 3, Iss s1 (2024)
The body’s homeostasis depends on the vascular endothelium, which controls angiogenesis, vascular tone, inflammation, cell trafficking, hemostasis, and the movement of nutrients and waste out of the body. Endothelial cells (ECs) are the primary gat
Externí odkaz:
https://doaj.org/article/ca8291ad71f544e3b6f69b7c7d88948a
Autor:
Clive Drakeford, Sonia Aguila, Fiona Roche, Karsten Hokamp, Judicael Fazavana, Mariana P. Cervantes, Annie M. Curtis, Heike C. Hawerkamp, Sukhraj Pal Singh Dhami, Hugo Charles-Messance, Emer E. Hackett, Alain Chion, Soracha Ward, Azaz Ahmad, Ingmar Schoen, Eamon Breen, Joe Keane, Ross Murphy, Roger J. S. Preston, Jamie M. O’Sullivan, Frederick J. Sheedy, Padraic Fallon, James S. O’Donnell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
von Willebrand factor (VWF) plays a critical role in primary hemostasis following vascular injury by tethering platelets to exposed collagen. Here, VWF binding to macrophages is shown to trigger NF-κB activation and induce pro-inflammatory responses
Externí odkaz:
https://doaj.org/article/0abf998c232d43bcab767dde021ae471
Autor:
Niamh O'Regan, Kristina Gegenbauer, Eimear M. Gleeson, Kenji Fukudome, Jamie M. O'Sullivan, Clive Drakeford, Niall Dalton, Alain Chion, Teresa M. Brophy, Owen P. Smith, Roger J.S. Preston, James S. O'Donnell
Publikováno v:
Haematologica, Vol 107, Iss 8 (2022)
Externí odkaz:
https://doaj.org/article/915af75fe6c7477c8bc22b31031e043d
Autor:
Claire Comerford, Sukhraj Pal Singh Dhami, Philip Murphy, Sean Patmore, Soracha Ward, Nadiya Pushkar, Ulrich Budde, Ellie Karampini, James S. O'Donnell, Siobhan Glavey, John Quinn, Jamie M. O'Sullivan
Publikováno v:
Thrombosis Research. 226:136-140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb582474cc72bff6a0f9e3b15c13696c
https://doi.org/10.1016/j.thromres.2023.04.014
https://doi.org/10.1016/j.thromres.2023.04.014
Autor:
Jamie M O'Sullivan, James S O'Donnell
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-3 (2020)
Abstract In this issue of EMBO Molecular Medicine, Barbon et al describe a new approach to rebalancing coagulation in patients with hemophilia (PWH) through targeted inhibition of anticoagulant antithrombin (AT) (Barbon et al, 2020). In contrast to p
Externí odkaz:
https://doaj.org/article/4feab2c141c64fd9ba19fa20a4bfd5d5
Autor:
Soracha E. Ward, Jamie M. O’Sullivan, Alan B. Moran, Daniel I. R. Spencer, Richard A. Gardner, Jyotika Sharma, Judicael Fazavana, Marco Monopoli, Thomas A.J. McKinnon, Alain Chion, Sandra Haberichter, James S. O’Donnell
Publikováno v:
Haematologica, Vol 107, Iss 3 (2021)
Terminal sialylation determines the plasma half-life of von Willebrand factor (VWF). A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we showed that MGL influences phys
Externí odkaz:
https://doaj.org/article/df84523d82df4f9a98f0024a5a9002a7
Autor:
Dearbhla Doherty, Michelle Lavin, Mary Byrne, Margaret Nolan, Jamie M. O’Sullivan, Kevin Ryan, Niamh M. O’Connell, Sandra L. Haberichter, Pamela A. Christopherson, Jorge Di Paola, Paula D. James, James S. O’Donnell
Publikováno v:
Blood Advances. 7:302-308
Increased von Willebrand factor (VWF) clearance plays a key role in the pathogenesis of type 1 and type 2 von Willebrand disease (VWD). However, the pathological mechanisms involved in patients with mild to moderate reductions in plasma VWF:Ag (range
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1a5dcbccd7171a6ae0bf4fd033227d
https://doi.org/10.1182/bloodadvances.2022007340
https://doi.org/10.1182/bloodadvances.2022007340
Autor:
Michelle Lavin, Sonia Aguila, Niall Dalton, Margaret Nolan, Mary Byrne, Kevin Ryan, Barry White, Niamh M. O'Connell, Jamie M. O'Sullivan, Jorge Di Paola, Paula D. James, James S. O'Donnell
Publikováno v:
Blood Advances, Vol 2, Iss 14, Pp 1784-1791 (2018)
Abstract: Gynecological bleeding is frequently reported in women with von Willebrand disease (VWD). Low von Willebrand factor (VWF) may be associated with significant bleeding phenotype despite only mild plasma VWF reductions. The contribution of gyn
Externí odkaz:
https://doaj.org/article/2abefa265d3e497da0dc856cd46d5ae6
Autor:
Helen Fogarty, Soracha E. Ward, Liam Townsend, Ellie Karampini, Stephanie Elliott, Niall Conlon, Jean Dunne, Rachel Kiersey, Aifric Naughton, Mary Gardiner, Mary Byrne, Colm Bergin, Jamie M. O'Sullivan, Ignacio Martin-Loeches, Parthiban Nadarajan, Ciaran Bannan, Patrick W. Mallon, Gerard F. Curley, Roger J.S. Preston, Aisling M. Rehill, Ross I. Baker, Cliona Ni Cheallaigh, James S. O'Donnell, Niamh O’Connell, Kevin Ryan, Dermot Kenny, Judicael Fazavana
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2429-2438
Prolonged recovery is common after acute SARS-CoV-2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown. VWF/ADAMTS-13 imbalance, dysregulated angiogenesis, and immunothrombosis are hallmarks of acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298a1c9afccda226ce7200f043c7d149
https://doi.org/10.1111/jth.15830
https://doi.org/10.1111/jth.15830
Autor:
Sukhraj Pal Singh Dhami, Sean Patmore, Claire Comerford, Ciara M. Byrne, Brenton Cavanagh, John Castle, Cliona C. Kirwan, Martin Kenny, Ingmar Schoen, James S. O'Donnell, Jamie M. O'Sullivan
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2350-2365
Breast cancer results in a three- to four-fold increased risk of venous thromboembolism (VTE), which is associated with reduced patient survival. Despite this, the mechanisms underpinning breast cancer-associated thrombosis remain poorly defined. Tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b88d1e6fa8d856c8ff041b6cc4a776
https://doi.org/10.1111/jth.15794
https://doi.org/10.1111/jth.15794